Results 51 to 60 of about 38,452 (298)

1,2,4-Triazoles. VII. Methylation of 1,2,4-triazoles.

Chemical and Pharmaceutical Bulletin, 1976
The methylations of twenty-five 1, 2, 4-triazoles with methyl iodide and diazomethane were studied and substituent effects on the product ratios are discussed. Methylation of 1, 2, 4-triazole and its symmetrically 3, 5-disubstituted derivatives occurred almost exclusively at the 1-position.
UDA, MASAYUKI, HISAZUMI, YUKINORI, SATO, KOJI, KUBOTA, SEIJU   +3 more
openaire   +2 more sources

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Synthesis of alpha-tetrasubstituted triazoles by copper-catalyzed silyl deprotection/azide cycloaddition

Beilstein Journal of Organic Chemistry, 2015
Propargylamines are popular substrates for triazole formation, but tetrasubstituted variants have required multistep syntheses involving stoichiometric amounts of metal.
Zachary L. Palchak, Paula T. Nguyen, Catharine H. Larsen   +2 more
doaj   +1 more source

3-Aryl Substituted Triazole Derivatives as New and Effective Corrosion Inhibitors for Mild Steel in Hydrochloric Acid Solution

International Journal of Electrochemical Science, 2012
The corrosion inhibition properties of three triazoles derivatives namely 4-amino-5-phenyl-4H-1, 2, 4,-triazole-3-thiol (APTT), 4-amino-5-(2-hydroxy) phenyl-4H-1, 2, 4,-triazole-3-thiol, (AHPTT), 4-amino-5-styryl-4H-1, 2, 4,-triazole-3-thiol, (ASTT) on ...
M.A. Quraishi, Sudheer, K.R. Ansari, Eno E. Ebenso   +3 more
doaj   +1 more source

A study of actoprotective activity of new 3-(thiophen-2-ylmethyl)-1H-1,2,4-triazole-5-thiol derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The issue of fatigue is quite topical for the modern humanity. In order to work harder and earn as much money as possible, a person takes various stimulants, which have a number of side effects.
A. A. Safonov
doaj   +1 more source

Photoelectrocatalytic Diazidation of Olefins via Synergistic Dual Iron Species

Advanced Science, EarlyView.
We report a simple and general approach for 1,2‐diazidation of alkenes by a photoelectrochemical strategy using TMSN3 as an azide source. This transformation proceeds using earth‐abundant iron under mild reaction conditions. It displays broad functional group compatibility and accommodates diverse alkene types‐including unactivated, activated, electron‐
Zhi‐Peng Guan, Zhong‐Qi Yi, Ning Li, He‐Yi Li, Jun Yao, Hong‐Gui Huang, Zhi‐Bing Dong   +6 more
wiley   +1 more source

Molecular Glue Degraders of TEM β‐Lactamases by Periplasmic Protease DegP

Angewandte Chemie, EarlyView.
Molecular glues are developed that target TEM‐family β‐lactamases to the bacterial protease DegP for degradation. β‐Lactamase inhibitor tazobactam is identified as accelerating TEM β‐lactamase degradation by DegP, which is further enhanced by linkerless incorporation of dipeptides enriched among DegP substrates.
Emilia K. Taylor, Patricia Santos Barbosa, Tarini Kadambi, Frederik Eisele, Yiqiao Wang, Elisabete C. C. M. Moura, Timothy R. Walsh, Georgia L. Isom, Thomas Lanyon‐Hogg   +8 more
wiley   +2 more sources

Evaluation of some functionalized imidazoles and 1,2,4-triazoles as antioxidant additives for industrial lubricating oils and correlating the results with the structures of additives using empirical AM1 calculations

Journal of Saudi Chemical Society, 2011
Functionalized 4,5-diphenyl-imidazoles, 4,5-diphenyl-1,2,4-triazoles and 5-(o-hydroxyphenyl)-4-phenyl-1,2,4-triazoles at the 2-position with thiol, thiomethyl and thiobenzyl groups, have been tested as antioxidant additives for lubricating oils.
El Sayed H. El Ashry, Esam EL-Rafey, Nadjet Rezki, Hamdy H. Abou-Elnaga, Wedad M. A. Bakry, Yasser M. Boghdadi   +5 more
doaj   +1 more source

Safety and Efficacy of Intermittent High-Dose Liposomal Amphotericin B Antifungal Prophylaxis in Haemato-Oncology: An Eight-Year Single-Centre Experience and Review of the Literature

Journal of Fungi, 2020
Triazoles remain first-line agents for antifungal prophylaxis in high-risk haemato-oncology patients, but their use is increasingly contraindicated due to drug–drug interactions and additive toxicities with novel treatments. In this retrospective, single-
Jonathan Youngs, Jen Mae Low, Laura Whitney, Clare Logan, Janice Chase, Ting Yau, Matthias Klammer, Mickey Koh, Tihana Bicanic   +8 more
doaj   +1 more source