Results 61 to 70 of about 1,301 (158)

Synthesis and In Vitro Antiproliferative Activity of Novel Androst-5-ene Triazolyl and Tetrazolyl Derivatives

Molecules, 2011
A straightforward and reliable method for the regioselective synthesis of steroidal 1,4-disubstituted triazoles and 1,5-disubstituted tetrazoles via copper(I)-catalyzed cycloadditions is reported. Heterocycle moieties were efficiently introduced onto the
János Wölfling, Tibor Bartók, Éva Frank, Gyula Schneider, Judit Huber, István Zupkó, Dóra Kovács, Zalán Kádár   +7 more
doaj   +1 more source

Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges

Angewandte Chemie International Edition, EarlyView.
Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley   +1 more source

Nuclear Quadrupole Resonance Spectroscopy: Tautomerism and Structure of Functional Azoles

Crystals, 2019
The Nuclear Quadrupole Resonance spectroscopy data of functionalized azoles (imidazoles, triazoles and corresponding benzazoles) are reviewed and critically discussed. The possibility of studying the tautomerism of azoles by the NQR method is considered.
Lyudmila I. Larina
doaj   +1 more source

Unlocking Catalyst Activation as a Critical Bottleneck in Cross‐Coupling Reactions: Room‐Temperature Couplings of Weak Nucleophiles Enabled by [Pd(1‐MeNAP)TFA]2 Precatalysts

Angewandte Chemie International Edition, EarlyView.
In many Pd‐catalyzed cross‐couplings, catalyst performance has been found to be limited by catalyst activation. Methylnaphthyl (MeNAP) palladium trifluoroacetate dimers are presented as easy‐to‐store and easy‐to‐handle precursors, which rapidly activate under reaction conditions, even when only weakly coordinating, non‐reducing nucleophiles are present.
Sourav Manna, Henric F. Janning, Nikolaos V. Tzouras, Jane Anto Simplica Sagayaraj, Fadil Faizal Mannighayil, Angelino Doppiu, Lukas J. Gooßen   +6 more
wiley   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Progress and Prospects of Triazoles in Advanced Therapies for Parasitic Diseases

Tropical Medicine and Infectious Disease
Parasitic diseases represent a severe global burden, with current treatments often limited by toxicity, drug resistance, and suboptimal efficacy in chronic infections.
Jaime A. Isern, Renzo Carlucci, Guillermo R. Labadie, Exequiel O. J. Porta   +3 more
doaj   +1 more source

Anticancer properties of 1,2,4-triazole derivatives (literature review)

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Cancer is still one of the leading causes of death worldwide. Statistical data show that more than 130,000 people in Ukraine receive this diagnosis as a sentence every year. Cancer can affect any organ and eventually the whole body. In most cases, cancer
I. V. Bushuieva, M. V. Parchenko
doaj   +1 more source

Clinical safety and tolerability issues in use of triazole derivatives in management of fungal infections

Drug, Healthcare and Patient Safety, 2010
Dionissios Neofytos1, Edina Avdic2, Anna-Pelagia Magiorakos31Transplant and Oncology Infectious Disease Program, The Johns Hopkins University School of Medicine, Division of Infectious Diseases, 2Department of Pharmacy, The Johns Hopkins Hospital ...
Dionissios Neofytos, Edina Avdic, Anna-Pelagia Magiorakos   +2 more
doaj  

Enantioselective copper-catalyzed azidation/click cascade reaction for access to chiral 1,2,3-triazoles

Nature Communications
Chiral 1,2,3-triazoles are highly attractive motifs in various fields. However, achieving catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a significant challenge, mainly due to the limited catalytic ...
Ling-Feng Jiang, Shao-Hua Wu, Yu-Xuan Jiang, Hong-Xiang Ma, Jia-Jun He, Yang-Bo Bi, De-Yi Kong, Yi-Fei Cheng, Xuan Cheng, Qing-Hai Deng   +9 more
doaj   +1 more source

The Click Reaction as an Efficient Tool for the Construction of Macrocyclic Structures

Molecules, 2013
The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC, known as the click reaction) is an established tool used for the construction of complex molecular architectures.
Dario Pasini
doaj   +1 more source