Results 81 to 90 of about 37,042 (298)

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie, EarlyView.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +2 more sources

Synthesis and antimicrobial activity of 3,5-R-4-(3-(5-nitrofuran-2-yl)-allylidenamino)-1-R1-4H-1,2,4-triazole halides derivatives

Zaporožskij Medicinskij Žurnal, 2015
Aim. A number of new 3,5-R-4-(3-(5-nitrofuran-2-yl)allylidenami-no)-1-R1-4H-1,2,4-triazole halides have been synthesized, the structure of synthesized compounds has been proved by modern physical-chemical methods. Methods and results.
T. S. Brytanova , A. S. Gotsulya, O. I. Panasenko, Ye. G. Knysh, N. S. Fedyunina   +4 more
doaj   +1 more source

Synthesis, bioevaluation and molecular docking study of new piperazine and amide linked dimeric 1,2,3-triazoles

, 2019
In search of more potent new antitubercular agents, a library of novel piperazine tethered dimeric 1,2,3-triazoles were designed by assembling 1,2,3-triazoles and piperazine in a single molecular architectural framework.
Jaiprakash N. Sangshetti (4842510), Tejshri R. Deshmukh (8051162), Vijay M. Khedkar (554344), Vagolu S. Krishna (8051168), Dharmarajan Sriram (816698), Bapurao B. Shingate (8051171), Smita P. Khare (8051165)   +6 more
core   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source

A Mechanical Planar Chiral Rotaxane Induces Single‐Handed Helicity in a Twisted Perylene Diimide

Angewandte Chemie, EarlyView.
A mechanical planar chiral rotaxane (Rmp) is used to induce single‐handed helical chirality (M) in a perylene diimide chromophore, resulting in persistent circular dichroism (CD) and circularly polarised luminescence (CPL). ABSTRACT The twisting of chromophores such as perylene diimides (PDIs) into helical structures affords chiroptical properties from
Thomas E. Lawson, Denis Hartmann, Artemijs Krimovs, Qilong Sun, Robert Pal, Timothy A. Barendt   +5 more
wiley   +2 more sources

Access to Substituted Tricyclic Heteroarenes by an Oxidative Cyclization Reaction and Their Antifungal Performance

Pharmaceuticals
Background/Objectives: Fungal pathogens are increasingly developing concerning resistance against the currently available antifungal drugs, which creates a constant demand for new antifungal agents.
Rehema Nakiwala, Noopur Dasgupta, Rebecca Wilson, Erika I. Lutter, Jeanne L. Bolliger   +4 more
doaj   +1 more source

ZINClick v.18: Expanding Chemical Space of 1,2,3-Triazoles

, 2018
In the last years, we have investigated the click-chemical space covered by molecules containing the triazole ring and generated a database of 1,2,3-triazoles called ZINClick, starting from literature-reported alkynes and azides synthesizable in no more ...
Levré, Doriana, Mercalli, Valentina, Massarotti, Alberto, Alberto Massarotti, Doriana Levré, Chiara Arcisto, Valentina Mercalli (1520014), Alberto Massarotti (1520008), Arcisto, Chiara, Doriana Levré (6013466), Chiara Arcisto (6013469), Valentina Mercalli   +11 more
core   +1 more source

Design, synthesis, characterization and antimicrobial evaluation of amide tagged 1,4-disubstituted 1,2,3-triazoles

, 2023
A series of amide tagged 1,4-disubstituted 1,2,3-triazole has been designed and synthesized in good yield through Cu (I) catalyzed click chemistry strategy.
C. P. Kaushik (7494545), Priyanka Yadav (1726375), Archna Yadav (14093689), Jyoti Yadav (301590)   +3 more
core   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source