Results 81 to 90 of about 1,301 (158)

A Mononuclear Scenario for the Copper‐Catalyzed Monooxygenation of Phenolic Substrates

Chemistry – A European Journal, EarlyView.
ABSTRACT Whereas a dinuclear pathway applies to the monooxygenation of phenols by the type 3 copper enzyme tyrosinase, a mononuclear pathway has been identified for the same reaction in corresponding small‐molecule systems. DFT calculations of five copper model complexes reveal that the latter mechanism is energetically feasible, identifying all ...
Alexander Koch, Antony Memboeuf, Felix Tuczek, Tobias A. Engesser   +3 more
wiley   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Light‐Induced Anion Translocation to Control Helical Folding in an Artificial Communication System

Chemistry – A European Journal, EarlyView.
Anion‐induced helical folding of an oligomer is controlled indirectly and reversibly by light through anion uptake/release by a photoresponsive receptor. Thus, a light signal is processed into a chemical signal in a communication‐type three‐component supramolecular system.
Indigo M. Bekaert, Suchismita Saha, Julia Villalva, David Villarón, Maxime A. Siegler, Sander J. Wezenberg   +5 more
wiley   +1 more source

A Low‐Symmetry FeII Tetrahedron From a Flexible Tritopic Ligand

Chemistry – A European Journal, EarlyView.
A highly symmetric and flexible tris‐bidentate tritopic ligand forms an S4 meso homoleptic face‐capped FeII tetrahedron near‐quantitatively in acetonitrile. The addition of nitromethane solvent causes partial isomerization of this meso cage to the racemic homochiral tetrahedron, with the complexity of the system being moderated through solvophobic ...
Rosemary J. Goodwin, Nina R. Lawson, Michael G. Gardiner, Jack D. Evans, Paul E. Kruger, Dan Preston   +5 more
wiley   +1 more source

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, EarlyView.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Synthesis and Reactivity of 3‐Aminosydnones in Cycloaddition Reactions With Alkynes

Chemistry – A European Journal, EarlyView.
The synthesis, functionalization, and reactivity as dipoles of 3‐aminosydnones have been investigated. These neglected compounds undergo smooth cycloaddition reactions with strained alkynes, leading to 1‐aminopyrazoles. ABSTRACT We present in this article the synthesis, functionalization, and properties of 3‐aminosydnones, a forgotten class of ...
Apolline Dominic, Timothée D'anfray, Guillaume Force, David‐Alexandre Buisson, Maxime Tricoire, Alexis Leblais, Davide Audisio, Frédéric Taran   +7 more
wiley   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source

Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker

Chemistry – A European Journal, EarlyView.
ABSTRACT In this study, we report the synthesis of an alkylene linker containing a terminal 2‐cyanoethyl protected selenium functionality for coupling at the 5'‐end of an oligonucleotide by solid phase synthesis for the preparation of oligonucleotide conjugates.
Shivam Tikoo, Anne M. Noronha, Christopher J. Wilds   +2 more
wiley   +1 more source

S‐Doped Carbon Nitride Thin Films From a Triazole Precursor

Carbon Innovation, EarlyView.
Sulfur‐functionalized carbon nitride thin films are synthesized via low‐temperature chemical vapor deposition using a triazole‐derived precursor. Tunable sulfur incorporation modulates electronic and optical properties and enables efficient visible‐light photocatalysis with high conversion and selectivity.
Yen‐Han Wang, Enis Oğuzhan Eren, Baris Kumru, Paolo Giusto   +3 more
wiley   +1 more source

Boosting Zinc‐Ion Hybrid Capacitors with Mesoporous Carbon Derived from Highly Graphitized Carbon Quantum Dots

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
The work presents an innovative method for the preparation of mesoporous carbon materials (MCs) from highly graphitized carbon quantum dots. The zinc‐ion hybrid capacitors assembled with MCs deliver high rate performance and stability, providing promising advancements for future energy storage solutions.
Guoli Zhang, Huihui Li, Kaiyue Wang, Gang Li, Kaixi Li, Taotao Guan, Kaiying Wang   +6 more
wiley   +1 more source