Results 81 to 90 of about 26,604 (253)

Enantioselective copper-catalyzed azidation/click cascade reaction for access to chiral 1,2,3-triazoles

Nature Communications
Chiral 1,2,3-triazoles are highly attractive motifs in various fields. However, achieving catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a significant challenge, mainly due to the limited catalytic ...
Ling-Feng Jiang, Shao-Hua Wu, Yu-Xuan Jiang, Hong-Xiang Ma, Jia-Jun He, Yang-Bo Bi, De-Yi Kong, Yi-Fei Cheng, Xuan Cheng, Qing-Hai Deng   +9 more
doaj   +1 more source

The Click Reaction as an Efficient Tool for the Construction of Macrocyclic Structures

Molecules, 2013
The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC, known as the click reaction) is an established tool used for the construction of complex molecular architectures.
Dario Pasini
doaj   +1 more source

Clinical safety and tolerability issues in use of triazole derivatives in management of fungal infections

Drug, Healthcare and Patient Safety, 2010
Dionissios Neofytos1, Edina Avdic2, Anna-Pelagia Magiorakos31Transplant and Oncology Infectious Disease Program, The Johns Hopkins University School of Medicine, Division of Infectious Diseases, 2Department of Pharmacy, The Johns Hopkins Hospital ...
Dionissios Neofytos, Edina Avdic, Anna-Pelagia Magiorakos   +2 more
doaj  

A Fixed‐Charge Interphase Synchronizes Ion Transport to Suppress Space‐Charge‐Driven Inefficiency Under Nanoliter Confinement

Angewandte Chemie International Edition, EarlyView.
Electrochemical energy storage breaks down under extreme miniaturization, where interfaces and space‐charge dominate device behavior. This work introduces a fixed‐charge selective interphase (FCSI) integrated into a twin‐tube micro‐Swiss‐roll architecture.
Yaping Yan, Jiachen Ma, Wenlan Zhang, Hongmei Tang, Yue Li, Ruhuai Mei, Yang Huang, Daniil Karnaushenko, Dmitriy D. Karnaushenko, Yumin Luo, Kai Zhang, Oliver G. Schmidt, Minshen Zhu   +12 more
wiley   +1 more source

Synthesis, characterization and thermogravimetric study of Cu(II) adducts with 3- and 4-amino-1,2,4-triazole, 2-mercaptothiazoline and 2-mercaptopyridine [PDF]

Journal of the Serbian Chemical Society, 2006
The adducts CuCl2·(3amt), CuCl2·2(3amt)·2H2O, CuCl2·3(3amt), CuCl2·(4amt), CuCl2·2(4amt), CuCl2·3(4amt)·2H2O, CuCl2·(2mct)·H2O, CuCl2·2(2mct)·2.5H2O, CuCl2·3(2mct)·2H2O, CuCl2·(2mcp) and CuCl2·2(2mcp)·H2O, where 3-amino-1,2,4-triazole = 3amt, 4-amino-1,2,
MOAMEN S. REFAT, ROBSON F. DE FARIAS
doaj  

Triazole-based STING inhibitors

Bioorganic & Medicinal Chemistry
Aberrant activation of the DNA sensing cGAS-STING pathway has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), systemic lupus erythematosus (SLE), and autoinflammatory disorders such as Aicardi-Goutières syndrome (AGS) and STING-associated vasculopathy with onset in infancy (SAVI). Consequently, considerable efforts have been
Singh, Anju, Barasa, Leonard, DeOrsey, Leo, O’Reilly, Maeve D., Choudhary, Shruti, Cahill, Sara E., Rossetti, Thomas, Green, Robert Madison, Humphries, Fiachra, Thompson, Paul R.   +9 more
openaire   +2 more sources

Peptide Thioester and Triazole Derivatives Through On‐Resin Dual‐Modification of Peptide Thiosulfonates

Angewandte Chemie International Edition, EarlyView.
An on‐resin dual‐modification strategy for peptides is presented, comprising S‐alkynylation of peptide thiosulfonates and regioselective iridium‐catalyzed azide–thioalkyne cycloaddition. This method reliably provides access to peptides with intricate non‐canonical modifications, being compatible with complex peptides, alkynes and azides.
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

The Jekyll and Hyde Nature of Tetrazoles in Polymer Science: From Intrinsic Electronic Duality to Programmable Macromolecular Function

Angewandte Chemie International Edition, EarlyView.
Tetrazoles are reframed as substitution‐programmable heterocycles rather than static functional groups in polymer chemistry. By linking electronic identity to synthetic strategy and polymer architecture, this mini‐review establishes a design framework for translating tetrazole duality into predictable macromolecular function.
Meryem S. Akdemir, Hatice Mutlu
wiley   +1 more source

Synthesis of 1,2,3-triazoles and applications in the synthesis of BODIPY triazoles

, 2020
The 1,2,3-triazole ring is an important heterocycle which has found wide applications due to its interesting properties. Mainly due to the advent of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, 1,2,3-triazoles are nowadays unavoidable in the chemical literature. In the past decade, the development of transition metal-free synthetic
openaire   +2 more sources

Anomeric Amide Enabled Divergent Synthesis of Unsymmetrical Ureas, Carbamates, Thioesters, and Amides From Aldehydes

Angewandte Chemie International Edition, EarlyView.
An anomeric amide‐enabled divergent aldehyde functionalization sequence provides one‐pot access to unsymmetrical ureas, carbamates, thiocarbamates, thioesters, and amides. Key to this transformation is the formation of N‐Boc‐hydroxamate intermediates, which serve as platforms for orthogonal activation via Lossen‐type rearrangements, single‐electron ...
Jasper L. Tyler, Meiyi Zeng, Julius Wiener, Marie‐Christin Leusmann, Colin Stein, Constantin G. Daniliuc, Frank Glorius   +6 more
wiley   +1 more source