Results 121 to 130 of about 26,604 (253)

Analysis of interactions between posaconazole/voriconazole and venetoclax. [PDF]

Antimicrob Agents Chemother
Liu C, Xie X, Sun M, Hang P, Lyu J, Shi Y, Gao X, Xu W, Zhu H.   +8 more
europepmc   +1 more source

Protein‐Based High‐Performance Liquid Chromatography and Cyclodextrin‐Capillary Electrokinetic Chromatography for the Chiral Separation of Azoles

ELECTROPHORESIS, EarlyView.
Human serum albumin‐based high‐performance liquid chromatography and cyclodextrin‐based capillary electrokinetic chromatography were used for the chiral separation of azoles. Although only two of the five tested azoles could be enantioseparated by liquid chromatography, all of them were separated by capillary electrokinetic chromatography using single ...
Sarah Moreau, Amy Dillon, Giacomo Russo, Susanne K. Wiedmer   +3 more
wiley   +1 more source

Flow Chemistry Meets Green Solvents: Telescoped Synthesis of Triazolyl Phosphoramidates and Phosphinamides in γ-Valerolactone. [PDF]

ChemSusChem
Gerő V, Steinsits D, Szabó PT, Bálint E.   +3 more
europepmc   +1 more source

Recent advances and prospects for high‐efficiency blue hot exciton organic light‐emitting diodes

FlexMat, EarlyView.
Blue organic light‐emitting diodes (OLEDs) face great challenges in achieving the balance between color purity, device efficiency, and stability. Hot exciton materials offer a solution by rapidly converting non‐emissive triplet excitons into singlet ones through a high‐lying reverse intersystem crossing process.
Xiaoen Shi, Shuyuan Ge, Futong Liu, Ping Lu   +3 more
wiley   +1 more source

Copper-catalyzed enantioselective interrupted azide-alkyne cycloaddition to access axially chiral diaryl ethers. [PDF]

Chem Sci
Wu R, Chen L, Chen Y, Wu Q, Chen Q, Lin A, Yao H, Li Q, Gao S.   +8 more
europepmc   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Design, click-based synthesis, molecular docking, molecular dynamics and anticancer activity of new isoindoline-1,3-dione- triazole-glycopyranosyl hybrids. [PDF]

Sci Rep
El-Bayaa MN, Alanzy AL, Alminderej FM, El-Manawaty MA, Messaoudi S, El-Sayed WA.   +5 more
europepmc   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Prevalence of cyp51A variants in a US collection of Aspergillus fumigatus clinical isolates and comparative analysis of their contribution to triazole antifungal resistance. [PDF]

J Antimicrob Chemother
Gómez Londoño LF, Souza ACO, Burt B, Das S, Ge W, Meza-Perez V, Wiederhold NP, Shelat AA, Cuomo CA, Fortwendel JR, Rogers PD.   +10 more
europepmc   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, EarlyView.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source