Results 121 to 130 of about 38,452 (298)
Antimicrobial Screening of Some Newly Synthesized Triazoles
, 2017 The study deals with the synthesis and evaluation of some novel triazoles. Amine linked triazoles were prepared through multistep syntheses. 4-Iodobenzoic acid was taken as initial reactant material, which was converted into methyl ester, then to ...
Jeetendra Gupta +2 more
core +1 more source
Some aspects of the chemistry of 1,2,3,-triazoles [PDF]
, 1987 In a wide rang1ng reaction dimethyl diazomalonate reacted with pr1mary amines to yield the corresponding ammonium salts of 5-hydroxy-I,2,3-triazoles in high yields.
Lennon, Sean Patrick
core
, 2019 Chagas disease is a neglected tropical disease caused by the hemoflagellated parasite Trypanosoma cruzi (Kinetoplastida). The only available drug to treat chagasic patients in Brazil, the nitroheterocycle benznidazole, is effective solely during the ...
Otávio A. Chaves (5670620) +10 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt +9 more
wiley +1 more source
A catalyst-free cascade reaction of 3-(2-isocyanoethyl)indoles and 1-sulfonyl-1,2,3-triazoles was realized. This dearomative spirocyclization provided an efficient protocol to synthesize a series of polycyclic indolines bearing spiro-α-carboline in ...
Han Wang (254423) +5 more
core +1 more source
, 2016 Reaction of 4-bromo-NH-1,2,3-triazoles 2 with alkyl halides in the presence of K2CO3 in DMF produced the corresponding 2-substituted 4-bromo-1,2,3-triazoles 5 in a regioselective process.
Diana C. Reeves (1777177) +7 more
core +1 more source
Animal Research and One Health, EarlyView.This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen +2 more
wiley +1 more source
Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry
Bulletin of the Korean Chemical Society, EarlyView.Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah +8 more
wiley +1 more source
, 2015 A series of energetic polynitro-aryl-1,2,3-2H-triazoles are synthesized from readily accessible aryl-1,2,3-2H-triazoles. X-ray diffraction analysis established the solid-state structures of several representative molecules.
Kumar, A. Sudheer +9 more
core +1 more source
Bulletin of the Korean Chemical Society, EarlyView.Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon +3 more
wiley +1 more source