Results 11 to 20 of about 126,240 (387)

Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications

Frontiers in Molecular Biosciences, 2022
Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Structurally, there are two types of five-membered triazoles: 1,2,3-triazole and 1,2,4-triazole.
Mohammed M. Matin, Priyanka Matin, Md. Rezaur Rahman, Taibi Ben Hadda, Faisal A. Almalki, Shafi Mahmud, Mohammed M. Ghoneim, Maha Alruwaily, Sultan Alshehri   +8 more
doaj   +2 more sources

Progress and Prospects of Triazoles in Advanced Therapies for Parasitic Diseases. [PDF]

Trop Med Infect Dis
Parasitic diseases represent a severe global burden, with current treatments often limited by toxicity, drug resistance, and suboptimal efficacy in chronic infections.
Isern JA, Carlucci R, Labadie GR, Porta EOJ.   +3 more
europepmc   +2 more sources

Torsade de Pointes/QT Prolongation Associated with Antifungal Triazoles: A Pharmacovigilance Study Based on the U.S. FDA Adverse Event Reporting System（FAERS）

Journal of Pharmacy & Pharmaceutical Sciences, 2022
Purpose: Torsade de pointes (TdP)/QT prolongation is a fatal adverse event (AE) when using antifungal triazoles. We aimed to compare the AE signals of TdP/QT prolongation and onset time among different drugs of this kind comprehensively.
Zicheng Yu, Xiaolan Liao
doaj   +1 more source

Efficacy and safety of triazoles versus echinocandins in the treatment of invasive aspergillosis: A meta-analysis [PDF]

Vojnosanitetski Pregled, 2020
Backgroun/Aim. Although majority of guidelines recommend triazoles (voriconazole, posaconazole, itraconazole and isavuconazole) as first-line therapeutic option for treatment of invasive aspergillosis, echinocandins (caspofungin, micafungin and ...
Uzelac Sanja M., Živković-Zarić Radica S., Radovanović Milan R., Ranković Goran Ž., Jankovic Slobodan M.   +4 more
doaj   +1 more source

Novel 1, 2, 4-Triazoles as Antifungal Agents

BioMed Research International, 2022
The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity.
Zahra Kazeminejad, M. Marzi, A. Shiroudi, S. Kouhpayeh, M. Farjam, E. Zarenezhad   +5 more
semanticscholar   +1 more source

Synthesis methods of 1,2,3-/1,2,4-triazoles: A review

Frontiers in Chemistry, 2022
Triazole, comprising three nitrogen atoms and two carbon atoms, is divided into two isomers 1,2,3-triazole and 1,2,4-triazole. Compounds containing a triazole are one of the significant heterocycles that exhibit broad biological activities, such as ...
J. Dai, Sen Tian, Xue-Yong Yang, Zongliang Liu   +3 more
semanticscholar   +1 more source

1,2,3-Triazoles of 8-Hydroxyquinoline and HBT: Synthesis and Studies (DNA Binding, Antimicrobial, Molecular Docking, ADME, and DFT)

ACS Omega, 2021
A new series of 1,2,3-triazole hybrids containing either 2- or 4-hydroxyphenyl benzothiazole (2- or 4-HBT) and naphthalen-1-ol or 8-hydroxyquinoline (8-HQ) was synthesized in high yields and fully characterized.
Nidhi Nehra, Ram Kumar Tittal, V. Ghule
semanticscholar   +1 more source

1,2,4-Triazoles as Important Antibacterial Agents

Pharmaceuticals, 2021
The global spread of drug resistance in bacteria requires new potent and safe antimicrobial agents. Compounds containing the 1,2,4-triazole ring in their structure are characterised by multidirectional biological activity.
M. Strzelecka, P. Świątek
semanticscholar   +1 more source

Design and antiproliferative and antioxidant activities of furan-based thiosemicarbazides and 1,2,4-triazoles: their structure-activity relationship and SwissADME predictions

Medicinal Chemistry Research, 2021
Due to the limited number of drugs in current clinical use, the diverse biological applications of furan have encouraged the preparation of a wide variety of thiosemicarbazide and triazole derivatives for the purpose of developing new drug agents.
Yusuf Sıcak
semanticscholar   +1 more source

1,2,3-Triazoles as Biomimetics in Peptide Science

Molecules, 2021
Natural peptides are an important class of chemical mediators, essential for most vital processes. What limits the potential of the use of peptides as drugs is their low bioavailability and enzymatic degradation in vivo.
Naima Agouram, E. E. El Hadrami, A. Bentama   +2 more
semanticscholar   +1 more source