Fluorescent Carbazole‐Derived Aza[5]Helicenes: Synthesis, Functionalization, and Characterization
Chemistry – A European Journal, EarlyView.Variously substituted indolophenanthridines, indolocarbazoles, and cinnolinocarbazoles synthesized by ortho fusion from teraryl precursors show significant Stokes shifts, especially for the protonated states of indolophenanthridines and cinnolinocarbazole.
Inka Marten +2 more
wiley +1 more source
Directional Macrocycle Transport, Release, and Recapture Enabled by a Rotaxane Transporter
Chemistry – A European Journal, EarlyView.This study represents a bistable rotaxane that enables the directional shuttling, release, and recapture of a dibenzo‐24‐crown‐8 macrocycle upon addition of suitable chemical stimuli. This two‐step molecular transport and release can be followed by NMR and distinct changes in the molecular fluorescence. Based on rational molecular design, the liberated
Sohom Kundu +3 more
wiley +1 more source
Ferromagnetic and antiferromagnetic spin coupling in Ni4O4 cubane-type clusters with 4-amino-3,5-bis(hydroxymethyl)-1,2,4-triazole as a ligand. The x-ray structure of a new dumbbell-like double cubane cluster [PDF]
, 1987 W. Vreugdenhill +3 more
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Core‐Twisted, Cationic Perylene Diimides; Homochiral Dimerization and Chiroptical Anion Sensing
Chemistry – A European Journal, EarlyView.The installation of two 3‐methyl‐1,2,3‐triazolium heterocycles on the aromatic core of a perylene diimide (PDI) generates a twisted and cationic organic dye. As potent hydrogen bond donors, these groups enable the PDI to self‐assemble into discrete and robust homochiral dimers in solution.
Denis Hartmann +3 more
wiley +1 more source
Is Mycobacterial InhA a Suitable Target for Rational Drug Design?
ChemMedChem, EarlyView.InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet +7 more
wiley +1 more source
Complexes of 1,2,4-Triazoles, Part XVII The Crystal Structure of Tris-μ-(4-ethyl-1,2,4-triazole-N1,N2)- (4-ethyl-1,2,4-triazole-N1)-aquo-bis [bis(thiocyanato-N)- nickel(II)]hydrate, Ni2(C4N3H7)4(H2O)(NCS)4 ·H2O(x ≃ 2.5) [PDF]
, 1981 G. Vos +2 more
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ChemMedChem, EarlyView.This article describes the development of improved NEU1 inhibitors based on the 2‐deoxy‐2,3‐didehydro‐N‐acetyl neuraminic acid scaffold. A series of candidate inhibitors are designed containing bioisosteres of the C5‐amide group and evaluated for activity against NEU1‐4 enzymes.
Mostafa Radwan +2 more
wiley +1 more source
Propellants, Explosives, Pyrotechnics, Volume 47, Issue 12, December 2022., 2022 Abstract To establish a database of performance values in the small‐scale shock reactivity test (SSRT), common secondary explosives based on organic nitrates (e. g. PETN) and nitramines (e. g. RDX and HMX) as well as aromatic (e. g. TNT), heteroaromatic (e. g. TKX‐50 and MAD−X1) and open chain systems (e. g. FOX‐7) were investigated.
Lukas Bauer +3 more
wiley +1 more source
ChemMedChem, EarlyView.Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali +11 more
wiley +1 more source