Synthesis of 1-Fluoroalkyl-5-Substituted-1,2,3-Triazoles from Carbonyl-Stabilized Phosphonium Ylides. [PDF]
Tichý D +5 more
europepmc +1 more source
A telescoped three‐step continuous flow process enables the synthesis of organophosphorus 1,2,3‐triazoles in the biomass‐derived solvent γ‐valerolactone (GVL). The sequence integrates N‐phosphorylation, azidation, and Cu(I)‐catalyzed azide–alkyne cycloaddition (CuAAC), followed by in‐line copper removal, giving diverse triazoles in good to high overall
Viktória Gerő +3 more
wiley +1 more source
Synthesis and Pharmacological Evaluation of Novel 1,5-Disubstituted-3-amino-1,2,4-triazoles Designed as Multitarget Directed Ligands for Alzheimer's Disease Targets. [PDF]
Franco DP +10 more
europepmc +1 more source
A highly stereoselective desymmetrization of pseudo‐para diformyl[2.2]paracyclophanes is developed via chiral Brønsted acid‐catalyzed reductive amination. This protocol provides efficient access to enantiopure planar chiral paracyclophanes with broad substrate scope, excellent enantioselectivity, and versatile postsynthetic functionalization. Access to
Sandip Baban Shinde +4 more
wiley +1 more source
Jianhua Zhang +6 more
semanticscholar +1 more source
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Switchable pathways of multicomponent heterocyclizations of 5-amino-1,2,4-triazoles with salicylaldehydes and pyruvic acid. [PDF]
Sakhno YI +5 more
europepmc +1 more source
Etude sur les conditions de réintroduction des fongicides systémiques dans les programmes de lutte contre la maladie des raies noires au Cameroun dans la zone de prodcution de la banane dessert d'exportation : rapport narratif intermédiaire N°8 deuxième campagne de monitoring à la CDC/DELMONTE 2010 [PDF]
Ngando Essoh Otto, Josué +1 more
core
Acute Eruption in a Child With Acute Lymphoblastic Leukemia
Pediatric Dermatology, EarlyView.
L. Parra‐Navarro +2 more
wiley +1 more source
Multi‐Functional Adaptive Interfaces for Next‐Generation Wearable and Implantable Bioelectronics
Adaptive Biointerfaces: A comprehensive overview of next‐generation bioelectronics is presented, highlighting mechano‐adaptive and biophysiologically adaptive interfaces that enable stable, long‐term integration with living tissues. As illustrated in the image, adaptive interface strategies, including mechano‐adaptivity (e.g., injectability, shape ...
Jinhong Park +7 more
wiley +1 more source

