Results 281 to 290 of about 126,240 (387)

Greening of Monocyclic N- and O‑Azole Synthesis through Sonochemistry. [PDF]

ACS Omega
Hoffman GR, Saeed MM, Schoffstall AM.
europepmc   +1 more source

Semisynthesis of Novel Chalcone Hybrid Compounds Linked by 1,2,3-Triazole and Evaluation of Their Cytotoxic Effects

Yassine Laamari, Mourad Fawzi, Ali Oubella, Saad H. Alotaibi, Fawziah M. Alotaibi, Taoufik Rohand, Luc Van Meervelt, Hamid Morjani, My Youssef Ait Itto, Aziz Auhmani   +9 more
openalex   +1 more source

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

Metal-based triazoles as a medical marvel of the modern era: a comprehensive review. [PDF]

RSC Adv
Haseeb K, Mustafa MH, Zafar W, Hassan AU, Chohan ZH, Sumrra SH.   +5 more
europepmc   +1 more source

Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama, Hikari Sada, Takeshi Nanjo   +2 more
wiley   +1 more source

Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship

Angewandte Chemie, Volume 138, Issue 6, 2 February 2026.
Macrocycles are effective molecular glues to stabilize the 14‐3‐3/ChREBP interaction. Linker length modulation uncovered an inverse correlation between the macrocycle binding affinity to 14‐3‐3 and its cooperativity in 14‐3‐3/ChREBP stabilization.
Marloes A. M. Pennings, Merel A. W. van den Bosch, Ansgar Oberheide, Carlo J. A. Verhoef, Christian Ottmann, Albert J. Markvoort, Galen P. Miley, Luc Brunsveld   +7 more
wiley   +2 more sources

Thiocarbamoylimidates as Precursors of New 5-Amino-1,2,4-Triazole and Oxadiazole Derivatives In Silico Prediction of Absorption, Distribution, Metabolism, and Excretion Parameters. [PDF]

Chempluschem
Gatri O, Roisnel T, Cordier M, Dorcet V, Efrit ML, Fischmeister C.   +5 more
europepmc   +1 more source

Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö, Émeline Courtois, Anne Paakinaho, Sirpa Hartikainen, Valtteri Kaasinen, Alexis Elbaz, Anne C. M. Thiébaut, Ismaïl Ahmed, Anna‐Maija Tolppanen   +8 more
wiley   +1 more source

Photo Quiz: An uncommon culprit in a young woman with headaches-a numb face and a fungal trace. [PDF]

J Clin Microbiol
Tsai T-Y, Su T-C, Sun P-L, Wu P-W, Wu T-Y, Hwang L-E, Cheng A, Lin K-Y, Chen Y-C.   +8 more
europepmc   +1 more source

Coordination Studies of a Triazole‐Substituted 3H‐1,2,4‐Diazaphosphole: CC and CN Bond Activation Induced by Cobalt(0) and Nickel(0) Complexes

Zeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 2, 5 February 2026.
Reactions of a triazole‐substituted 3H‐1,2,4‐diazaphosphole with electron‐rich cobalt and nickel complexes result in the selective cleavage of CC and CN bonds on the triazole, forming chelate complexes with the activated diazaphosphole ligand. The reactivity of the recently reported 3H‐1,2,4‐diazaphosphole 1 toward electron‐rich Ni and Co complexes ...
Sebastian Hauer, Gábor Balázs, Justus Reitz, Max M. Hansmann, Robert Wolf   +4 more
wiley   +1 more source