Tricellulin forms homomeric and heteromeric tight junctional complexes
Cellular and Molecular Life Sciences, 2010Sealing of the paracellular cleft by tight junctions is of central importance for epithelia and endothelia to function as efficient barriers between the extracellular space and the inner milieu. Occludin and claudins represent the major tight junction components involved in establishing this barrier function.
Susanne M Krug +2 more
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Trictide, a tricellulin‐derived peptide to overcome cellular barriers
Annals of the New York Academy of Sciences, 2017AbstractThe majority of tight junction (TJ) proteins restrict the paracellular permeation of solutes via their extracellular loops (ECLs). Tricellulin tightens tricellular TJs (tTJs) and regulates bicellular TJ (bTJ) proteins. We demonstrate that the addition of recombinantly produced extracellular loop 2 (ECL2) of tricellulin opens cellular barriers ...
Susanne M Krug +2 more
exaly +3 more sources
Evidence of tricellulin expression by immune cells, particularly microglia
Biochemical and Biophysical Research Communications, 2011Tight junctions (TJs) are elaborate structures located on the apical region of epithelial cells that limit paracellular permeability. Tricellulin is a recently discovered TJ protein, which is concentrated at the structurally specialized tricellular TJs but also present at bicellular contacts between epithelial cells, namely in the stomach ...
Cibelle Mariano +2 more
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Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro
Medical Molecular Morphology, 2009Tricellulin was identified as the first marker of the tricellular tight junction, which forms at the meeting points of three cells, and it is required for the maintenance of the transepithelial barrier. Although it is also considered to be important for the mucosal barrier of the upper respiratory tract, little is known about its expression and ...
Tsuyoshi, Ohkuni +9 more
exaly +3 more sources
High tricellulin expression is associated with better survival in human hepatoblastoma
Histopathology, 2014AimsThe more differentiated fetal component of hepatoblastoma (HB) is characterized by increased expression of tight junction (TJ) proteins claudin‐1 and ‐2 when compared with embryonal component. Expression patterns of the recently identified TJ protein tricellulin and the epigenetic regulator enzyme EZH2 were investigated in epithelial subtypes of HB
Gábor Lendvai +2 more
exaly +4 more sources
Tricellulin, α-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia [PDF]
International Journal of Molecular Sciences, 2023 Dominik Michalski
exaly +2 more sources
Claudins and tricellulin in fibrolamellar hepatocellular carcinoma
Virchows Archiv, 2011Fibrolamellar hepatocellular carcinoma is a subtype of hepatocellular carcinoma occurring in non-cirrhotic liver at a younger age. The tumor expresses both hepatocellular and cholangiocellular markers. Previously, our group described overexpression of tight junction protein claudin 4 in cholangiocellular carcinoma in contrast to hepatocellular ...
Patonai, Attila +9 more
openaire +3 more sources
Tricellulin Modulates Transport of Macromolecules in the Salivary Gland
Journal of Dental Research, 2019Volume and composition of saliva are crucial for oral and systemic health. How substances, particularly macromolecules, are transported across the salivary gland epithelium has not been established in detail. Tricellulin is a component of tricellular tight junctions that form a central tube to serve as an important route for macromolecule transport ...
S.N. Min +6 more
openaire +2 more sources
Expression of tricellulin in epithelial cells and non-epithelial cells.
Histology and histopathology, 2013Tricellulin is the first molecular component of tricellular tight junctions at tricellular contacts where three epithelial cells meet, and it is required for the their formation and maintenance of the epithelial barrier. Tricellulin binds other tight junction proteins, and its expression and distribution are affected by the bicellular tight junction ...
Takashi, Kojima +5 more
openaire +2 more sources
Serum Zonulin, Claudin-5, junction Adhesion Molecule-A, Occludin and Tricellulin levels in children with autism spectrum disorder [PDF]
International Journal of Developmental DisabilitiesHAVVANUR EROĞLU +2 more
exaly +2 more sources