Regulatory mechanism of trichothecene biosynthesis in Fusarium graminearum [PDF]
Frontiers in Microbiology, 2023 Among the genes involved in the biosynthesis of trichothecene (Tri genes), Tri6 and Tri10 encode a transcription factor with unique Cys2His2 zinc finger domains and a regulatory protein with no consensus DNA-binding sequences, respectively.
Maydelene Xiao Xuan Liew +4 more
doaj +2 more sources
AN IN VITRO ESTIMATION OF CYTOTOXICITY OF FUSARIUM TRICHOTHECENE ON THE BREAST CANCER CELL LINE
Сибирский онкологический журнал, 2020 trichothecenes and their derivatives have recently attracted much attention of researchers with respect of their potential role in medicine, including for the treatment of different types of cancer.
Rin. S. Mukhammadiev +6 more
doaj +3 more sources
Role of the Gene tri14 in Biosynthesis of the Trichothecene Toxin Harzianum A in Trichoderma arundinaceum [PDF]
ToxinsTrichothecenes are a family of toxic metabolites produced by multiple fungal species. All trichothecene analogs include an epoxide-containing tricyclic structure known as 12,13-epoxytrichothec-9-ene (EPT) but differ by the presence, absence and types of ...
Natalia Martínez-Reyes +6 more
doaj +2 more sources
A Novel Trichothecene Toxin Phenotype Associated with Horizontal Gene Transfer and a Change in Gene Function in Fusarium [PDF]
Toxins, 2022 Fusarium trichothecenes are among the mycotoxins of most concern to food and feed safety. Production of these mycotoxins and presence of the trichothecene biosynthetic gene (TRI) cluster have been confirmed in only two multispecies lineages of Fusarium ...
Robert H. Proctor +6 more
doaj +2 more sources
Investigation on Trichothecene-Stimulated Lipid Peroxidation and Toxic Effects of Trichothecenes in Animals [PDF]
Acta Veterinaria Scandinavica, 1989 Three experiments were performed with mice intoxicated with trichothecene-contamined feed or directly into the stomach. Lipid peroxidation was estimated by the TBA value from liver samples, but since such a test seldom provided reliable results, lipid hydroperoxides and total carbonyl were also analyzed.
Eeva Karppanen +4 more
openalex +3 more sources
Toxins, 2013 Mycotoxins are fungal secondary metabolites contaminating food and causing toxicity to animals and humans. Among the various mycotoxins found in crops used for food and feed production, the trichothecene toxin deoxynivalenol (DON or vomitoxin) is one of ...
Marc Maresca
exaly +3 more sources
Synthesis of Trichodermin Derivatives and Their Antimicrobial and Cytotoxic Activities [PDF]
Molecules, 2019 Trichothecene mycotoxins are recognized as highly bioactive compounds that can be used in the design of new useful bioactive molecules. In Trichoderma brevicompactum, the first specific step in trichothecene biosynthesis is carried out by a terpene ...
Javier E. Barúa +9 more
doaj +4 more sources
A European Database of Fusarium graminearum and F. culmorum Trichothecene Genotypes
Frontiers in Microbiology, 2016 Fusarium species, particularly Fusarium graminearum and F. culmorum, are the main cause of trichothecene type B contamination in cereals. Data on the distribution of Fusarium trichothecene genotypes in cereals in Europe are scattered in time and space ...
Matias Pasquali +2 more
exaly +3 more sources
Phylogenetic Variation of Tri1 Gene and Development of PCR–RFLP Analysis for the Identification of NX Genotypes in Fusarium graminearum Species Complex [PDF]
Toxins, 2023 NX toxins have been described as a novel group of type A trichothecenes produced by members of the Fusarium graminearum species complex (FGSC). Differences in structure between NX toxins and the common type B trichothecenes arise from functional ...
Meiling Gao +5 more
doaj +2 more sources
The Emerging Fusarium graminearum NA3 Population Produces High Levels of Mycotoxins in Wheat and Barley [PDF]
ToxinsFusarium graminearum (Fg) is the primary causal agent of Fusarium head blight (FHB) in wheat, barley, and other small grains in North America and worldwide.
Nicholas A. Rhoades +3 more
doaj +2 more sources