Targeting Trichothecene Biosynthetic Genes
Biosynthesis of trichothecenes requires the involvement of at least 15 genes, most of which have been targeted for PCR. Qualitative PCRs are used to assign chemotypes to individual isolates, e.g., the capacity to produce type A and/or type B trichothecenes. Many regions in the core cluster (consisting of 12 genes) including intergenic regions have been
Wei, Songhong +4 more
openaire +3 more sources
Revisiting the PCR-Based Molecular Approaches for Mycotoxigenic Fusarium Species Detection and Quantification in Wheat. [PDF]
ABSTRACT Fusarium species cause yield losses in wheat production through fusarium head blight (FHB) and the associated contamination of regulated mycotoxins, such as trichothecenes and zearalenone. Despite the widespread use of PCR‐based molecular approaches for Fusarium detection, quantification, and chemotyping, most primers were developed prior to ...
Vijeandran K +9 more
europepmc +2 more sources
Biosynthetic Pathways and Regulation of Antibacterial Compounds From Endophytic Fungi: From Chemistry to Genomics and Biotechnology. [PDF]
Endophytic fungi encode abundant cryptic biosynthetic gene clusters that remain largely silent under conventional cultivation. This review highlights how genome mining, multi‐omics, and cluster activation strategies bridge the BGC‐to‐metabolite gap, enabling the discovery of structurally diverse antibacterial natural products with activity against ...
Eshboev F +8 more
europepmc +2 more sources
Identification and Characterization of Small Molecule Compounds That Modulate Trichothecene Production by Fusarium graminearum [PDF]
From the RIKEN Natural Products Depository (NPDepo) chemical library, we identified small molecules that alter trichothecene 15-acetyldeoxynivalenol (15-ADON) production by Fusarium graminearum. Among trichothecene production activators, a furanocoumarin
Kobayashi, Tetsuo +29 more
core +2 more sources
Influence of barley malting operating parameters on T-2 and HT-2 toxinogenesis of Fusarium langsethiae, a worrying contaminant of malting barley in Europe. [PDF]
The fungus Fusarium langsethiae, exclusively described in Europe at present, seems to have taken the place of other Fusarium species in barley fields over the last 5 years.
D. Pocaznoi +9 more
core +1 more source
Fusarium graminearum is the causal agent of Gibberella ear rot and produces trichothecene mycotoxins. Basic questions remain unanswered regarding the kernel stages associated with trichothecene biosynthesis and the kernel metabolites potentially involved
Vessela Atanasova-Penichon +11 more
doaj +1 more source
Deoxynivalenol (Vomitoxin)-Induced Anorexia Is Induced by the Release of Intestinal Hormones in Mice
Deoxynivalenol (DON), also known as vomitoxin, is a mycotoxin that can cause antifeeding and vomiting in animals. However, the mechanism of DON inducing anorexia is complicated.
Jianming Yue +6 more
doaj +1 more source
Modelling the relationship between environmental factors, transcriptional genes and deoxynivalenol mycotoxin production by strains of two Fusarium species [PDF]
The effect of changes in temperature/water activity (a(w)) on growth, deoxynivalenol (DON) production and trichothecene gene cluster expression (18 genes) for strains of Fusarium culmorum and Fusarium graminearum was studied.
Geisen, Rolf +5 more
core +1 more source
Mycotoxins: Risks, regulations and European co-operation [PDF]
Mycotoxins and mycotoxicises have been problems of the past and the present, but scientific attention for mycotoxins did not start until the early 1960’s.
Van Egmond Hans P.
doaj +1 more source
Modification of Deoxynivalenol by a Fungal Laccase Paired with Redox Mediator TEMPO
Mycotoxins such as deoxynivalenol introduce a health risk to the food supply and are costly to manage or avoid. Technologies for reducing or eliminating the toxicity of deoxynivalenol could be useful in a variety of processes, such as in preserving the ...
Hina Shanakhat +4 more
doaj +1 more source

