Results 31 to 40 of about 8,048 (181)

Detection of Type A Trichothecene Di-Glucosides Produced in Corn by High-Resolution Liquid Chromatography-Orbitrap Mass Spectrometry

Toxins, 2013
The existence of di-glucosylated derivative of T-2 toxin in plant (corn powder) was confirmed for the first time in addition to that of HT-2 toxin. These masked mycotoxins (mycotoxin glucosides) were identified as T-2 toxin-di-glucoside (T2GlcGlc) and HT-
Hitoshi Nagashima, Shigeru Sakamoto, Yuki Sago, Hiroyuki Nakagawa   +3 more
doaj   +1 more source

Type A Trichothecene Metabolic Profile Differentiation, Mechanisms, Biosynthetic Pathways, and Evolution in Fusarium Species—A Mini Review

Toxins, 2023
Trichothecenes are the most common Fusarium toxins detected in grains and related products. Type A trichothecenes are among the mycotoxins of greatest concern to food and feed safety due to their high toxicity.
Jianhua Wang, Mengyuan Zhang, Junhua Yang, Xianli Yang, Jiahui Zhang, Zhihui Zhao   +5 more
doaj   +1 more source

Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness

Toxins, 2014
Evidence for the role of oxidative stress in the pathophysiology of mycotoxin-related illness is increasing. The glutathione antioxidant and detoxification systems play a major role in the antioxidant function of cells.
Frederick T. Guilford, Janette Hope
doaj   +1 more source

Phylogenetic Variation of Tri1 Gene and Development of PCR–RFLP Analysis for the Identification of NX Genotypes in Fusarium graminearum Species Complex

Toxins, 2023
NX toxins have been described as a novel group of type A trichothecenes produced by members of the Fusarium graminearum species complex (FGSC). Differences in structure between NX toxins and the common type B trichothecenes arise from functional ...
Meiling Gao, Mengyuan Zhang, Jiahui Zhang, Xianli Yang, Mohamed F. Abdallah, Jianhua Wang   +5 more
doaj   +1 more source

Fumonisins, Trichothecenes and Zearalenone in Cereals [PDF]

International Journal of Molecular Sciences, 2008
Fumonisins are phytotoxic mycotoxins which are synthesized by various species of the fungal genus Fusarium such as Fusarium verticillioides (Sacc.) Nirenberg (ex F.moniliforme Sheldon) and Fusarium proliferatum. The trichothecene (TC) mycotoxins are secondary metabolites produce by species that belong to several fungal genera, especially Fusarium ...
OMURTAG, Gülden Zehra, Yazar, SELMA
openaire   +3 more sources

Pro-Inflammatory Effects of NX-3 Toxin Are Comparable to Deoxynivalenol and not Modulated by the Co-Occurring Pro-Oxidant Aurofusarin

Microorganisms, 2020
The type A trichothecene NX-3, produced by certain Fusarium graminearum strains, is similar to the mycotoxin deoxynivalenol (DON), with the exception that it lacks the carbonyl moiety at the C-8 position.
Lydia Woelflingseder, Nadia Gruber, Gerhard Adam, Doris Marko   +3 more
doaj   +1 more source

Separation of trichothecene mycotoxins in a matrix of hemp (Cannabis sativa L.) seed, and quantification of deoxynivalenol in hemp grain infected with Fusarium graminearum

JSFA reports, EarlyView.
Abstract Background Fusarium graminearum, one of the causal agents of ear rot in maize and head blight of cereal grains, also infects hemp (Cannabis sativa L. containing a maximum of 0.3% tetrahydrocannabinol or THC). This fungal pathogen produces trichothecene mycotoxins when it infects maize and cereal grains, but little is known about its production
Isabelle A. Kagan, Magdalena Ricciardi, Henry S. Smith, Rachel R. Schendel, Robert Pearce, Nicole Gauthier   +5 more
wiley   +1 more source

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, EarlyView.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

Establishment of a Human Cell‐Based In Vitro Test System for Investigating and Evaluating Cytotoxic and Immunomodulatory Effects of Indoor Mold

Environmental Toxicology, EarlyView.
ABSTRACT Mold growth in damp indoor environments is a widespread problem associated with respiratory health effects, though causal mechanisms remain incompletely understood. We established a human cell‐based in vitro test system using bronchial epithelial cells (NuLi‐1) and macrophages (THP‐1) to assess inhalation toxicity and immunomodulatory effects ...
Anja Wolff, Jessica Reinert, Silke Steinborn, Marion Berger, Judith Neuhoff, Lennart Marske, Kerttu Valtanen, Udo Jäckel, Stefanie Klar   +8 more
wiley   +1 more source

Reduced Toxicity of Trichothecenes, Isotrichodermol, and Deoxynivalenol, by Transgenic Expression of the Tri101 3-O-Acetyltransferase Gene in Cultured Mammalian FM3A Cells

Toxins, 2019
In trichothecene-producing fusaria, isotrichodermol (ITDol) is the first intermediate with a trichothecene skeleton. In the biosynthetic pathway of trichothecene, a 3-O-acetyltransferase, encoded by Tri101, acetylates ITDol to a less-toxic intermediate ...
Nozomu Tanaka, Ryo Takushima, Akira Tanaka, Ayaki Okada, Kosuke Matsui, Kazuyuki Maeda, Shunichi Aikawa, Makoto Kimura, Naoko Takahashi-Ando   +8 more
doaj   +1 more source