Results 51 to 60 of about 15,217 (246)

Reduced Toxicity of Trichothecenes, Isotrichodermol, and Deoxynivalenol, by Transgenic Expression of the Tri101 3-O-Acetyltransferase Gene in Cultured Mammalian FM3A Cells

open access: yesToxins, 2019
In trichothecene-producing fusaria, isotrichodermol (ITDol) is the first intermediate with a trichothecene skeleton. In the biosynthetic pathway of trichothecene, a 3-O-acetyltransferase, encoded by Tri101, acetylates ITDol to a less-toxic intermediate ...
Nozomu Tanaka   +8 more
doaj   +1 more source

Identification and Characterization of Small Molecule Compounds That Modulate Trichothecene Production by Fusarium graminearum [PDF]

open access: yes, 2018
From the RIKEN Natural Products Depository (NPDepo) chemical library, we identified small molecules that alter trichothecene 15-acetyldeoxynivalenol (15-ADON) production by Fusarium graminearum. Among trichothecene production activators, a furanocoumarin
85359   +19 more
core   +1 more source

Effects of four Fusarium toxins (fumonisin B(1), alpha-zearalenol, nivalenol and deoxynivalenol) on porcine whole-blood cellular proliferation. [PDF]

open access: yes, 2008
The in vitro effects of four Fusarium toxins, fumonisin B1 (FB1), a-zearalenol (a-ZEA), nivalenol (NIV) and deoxynivalenol (DON), on mitogen-induced cell proliferation were determined in swine whole-blood cultures.
DE LUNA, ROCCO   +3 more
core   +1 more source

Detection of T-2 Toxin in Wheat and Maize with a Portable Mass Spectrometer

open access: yesToxins, 2023
T-2 toxin is a mycotoxin routinely found as a contaminant of cereal grains worldwide. A portable mass spectrometer was adapted to enable the detection of T-2 toxin in wheat and maize by APCI-MS.
Chris M. Maragos
doaj   +1 more source

Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness

open access: yesToxins, 2014
Evidence for the role of oxidative stress in the pathophysiology of mycotoxin-related illness is increasing. The glutathione antioxidant and detoxification systems play a major role in the antioxidant function of cells.
Frederick T. Guilford, Janette Hope
doaj   +1 more source

Detection of Type A Trichothecene Di-Glucosides Produced in Corn by High-Resolution Liquid Chromatography-Orbitrap Mass Spectrometry

open access: yesToxins, 2013
The existence of di-glucosylated derivative of T-2 toxin in plant (corn powder) was confirmed for the first time in addition to that of HT-2 toxin. These masked mycotoxins (mycotoxin glucosides) were identified as T-2 toxin-di-glucoside (T2GlcGlc) and HT-
Hitoshi Nagashima   +3 more
doaj   +1 more source

UDP-Glucosyltransferases from Rice, Brachypodium, and Barley: Substrate Specificities and Synthesis of Type A and B Trichothecene-3-O-β-d-glucosides

open access: yesToxins, 2018
Trichothecene toxins are confirmed or suspected virulence factors of various plant-pathogenic Fusarium species. Plants can detoxify these to a variable extent by glucosylation, a reaction catalyzed by UDP-glucosyltransferases (UGTs).
H. Michlmayr   +11 more
semanticscholar   +1 more source

Hydrogen-Bonding Interactions in T-2 Toxin Studied Using Solution and Solid-State NMR

open access: yesToxins, 2011
The structure of T-2 toxin in the solid-state is limited to X-ray crystallographic studies, which lack sufficient resolution to provide direct evidence for hydrogen-bonding interactions.
Paul Hazendonk   +6 more
doaj   +1 more source

Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom, Podostroma cornu-damae.

open access: yesJournal of Natural Products, 2018
Three new macrocyclic trichothecenes (1-3) and five known related compounds (4-8) were isolated from the MeOH extract of a plate culture of the fungus Podostroma cornu-damae, a deadly poisonous mushroom. Miophytocen D (1) is a rearranged macrocyclic type
Seoung Rak Lee   +4 more
semanticscholar   +1 more source

New tricks of an old enemy: isolates of F usarium graminearum produce a type A trichothecene mycotoxin

open access: yesEnvironmental Microbiology, 2015
Summary The ubiquitous filamentous fungus F usarium graminearum causes the important disease Fusarium head blight on various species of cereals, leading to contamination of grains with mycotoxins. In a survey of F .
E. Varga   +13 more
semanticscholar   +1 more source

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