Results 41 to 50 of about 22,737 (222)
Frontiers in Immunology, 2021 Postoperative ileus (POI) is triggered by an innate immune response in the muscularis externa (ME) and is accompanied by bacterial translocation. Bacteria can trigger an innate immune response via toll-like receptor (TLR) activation, but the latter’s ...
Jana Enderes +14 more
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MORC3-84aa directly interacts with TRIF and inhibits its expression.
, 2023 (A) Immunoprecipitation and immunoblot analysis of Linear-Flag-MORC3-84aa and TRIF-Myc in HEK293 cells. (B) Immunoprecipitation and immunoblot analysis of Linear-Flag-MORC3-84aa in MsbC cells.
Weiwei Zheng (140828) +4 more
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Frontiers in Immunology, 2021 TLR4 activates two distinct signaling pathways involving adaptors MyD88 and TRIF to produce proinflammatory cytokines and type-I interferon respectively. How Leishmania donovani suppresses these pathways is not well studied.
Joyshree Karmakar, Chitra Mandal
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MORC3-84aa promotes autophagic degradation of TRIF.
, 2023 (A) MsbC cells were transfected with Linear-Flag-MORC3-84aa plasmids and treated DMSO, MG132 (15 mM), 3-MA (3 mM), and NH4Cl (20 mM) for 8 h. Then, the cell lysates were examined by Western blot.
Weiwei Zheng (140828) +4 more
core +1 more source
Biology Direct, 2022 Toll/Interleukin-1 receptor (TIR) domains are cytoplasmic domain that mediates receptor signalling. These domains are present in proteins like Toll-like receptors (TLR), its signaling adaptors and Interleukins, that form a major part of the immune system.
Shailya Verma, Ramanathan Sowdhamini
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TLR4 activation by lysozyme induces pain without inflammation
Frontiers in Immunology, 2023 Mostly, pain has been studied in association with inflammation, until recent studies which indicate that during bacterial infections, pain mechanisms could be independent of the inflammation.
Saurabh Yadav +3 more
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TRIF-Mediated TLR3 and TLR4 Signaling Is Negatively Regulated by ADAM15 [PDF]
The Journal of Immunology, 2013 Abstract TLRs are a group of pattern-recognition receptors that play a crucial role in danger recognition and induction of the innate immune response against bacterial and viral infections. The TLR adaptor molecule, Toll/IL-1R domain-containing adaptor inducing IFN (TRIF), facilitates TLR3 and TLR4 signaling and concomitant activation of
Suaad, Ahmed +4 more
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Interaction of TRIM38 and TRIF.
, 2012 (A) TRIM38 specifically interacts with TRIF. 293T cells transfected with plasmids expressing TRIM38-Myc and Flag-TRIF, Flag-TBK1, or Flag-IKKi. After 24 h, cell lysates were immunoprecipitated using anti-Flag agarose beads.
Xinlei Liu (128686) +6 more
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Huanan Nongye Daxue xuebaoObjectiveTo construct TIR-domain-containing adaptor-inducing interferon β (TRIF) gene knockout mouse NA cell line and hamster BHK-21 cell line using CRISPR/Cas9 technology, evaluate the proliferative capacity of rabies virus (RABV) in these knockout cell
Weitao HUANG +5 more
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Clinical and Developmental Immunology, 2012 Viral infections are able to induce autoimmune inflammation in the heart. Here, we investigated the role of virus-activated Toll-like receptor (TLR)3 and its adaptor TRIF on the development of autoimmune coxsackievirus B3 (CVB3) myocarditis in mice ...
Eric D. Abston +10 more
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