Results 21 to 30 of about 22,737 (222)

Liposomal lipopolysaccharide initiates TRIF-dependent signaling pathway independent of CD14. [PDF]

PLoS ONE, 2013
Lipopolysaccharide (LPS) is recognized by CD14 with Toll-like receptor 4 (TLR4), and initiates 2 major pathways of TLR4 signaling, the MyD88-dependent and TRIF-dependent signaling pathways.
Sachiko Watanabe, Yoshio Kumazawa, Joe Inoue   +2 more
doaj   +2 more sources

Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif

American Journal of Physiology-Renal Physiology, 2009
Viral RNA or bacterial products can activate glomerular mesangial cells via a subset of Toll-like receptors (Tlr). Because Tlr2-deficient mice were recently found to have attenuated nephrotoxic serum nephritis (NSN), we hypothesized that endogenous Tlr agonists can activate glomerular mesangial cells. Primary mesangial cells from C57BL/6 mice expressed
Lichtnekert, J, Vielhauer, V, Zecher, D, Kulkarni, O P, Clauss, S, Segerer, S, Hornung, V, Mayadas, T N, Beutler, B, Akira, S, Anders, H J   +10 more
openaire   +5 more sources

Absence of TRIF Signaling in Lipopolysaccharide-Stimulated Murine Mast Cells [PDF]

The Journal of Immunology, 2011
Abstract In macrophages, two signaling pathways, dependent on MyD88 or TIR domain-containing adaptor-inducing IFN-β (TRIF) signaling, emanate from the LPS receptor TLR4/MD-2. In this study, we show that in murine bone marrow-derived mast cells (BMMCs), only the MyD88-dependent pathway is activated by LPS.
Keck, S., Müller, I., Fejer, G., Savic, I., Tchaptchet, S., Nielsen, P., Galanos, C., Huber, M., Freudenberg, M.   +8 more
openaire   +4 more sources

Reduced expression of TRIF in chronic HBV infected Iranian patients

Clinics and Research in Hepatology and Gastroenterology, 2013
TRIF is one of the main intracellular adaptor proteins required for TLR3 and 4 signaling. Abnormal gene expression of TRIF may lead to abrogated immune responses against viral infections including hepatitis B infection. The aim of this study was to identify the mRNA levels of TRIF in PBMCs isolated from chronic HBV (CHB) infected patients.mRNA was ...
Ayoobi, Fatemeh, Hassanshahi, Gholamhossein, Zainodini, Nahid, Khorramdelazad, Hossein, Arababadi, Mohammad Kazemi, Kennedy, Derek   +5 more
openaire   +4 more sources

MyD88-Family Adaptors: Compartmentalised Signalling and Non-Immune Functions. [PDF]

Immunology
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Pothabathula SV, Mishra S, Kannan P, Bellar A, Attaway A, Welch N, Dasarathy S.   +6 more
europepmc   +2 more sources

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer-Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy. [PDF]

Adv Sci (Weinh)
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Guo X, Zhao Y, Rong X, Chen X, Wang X, Liu T, Xie Y, Zou Y, Zhao P, Liu Q, You F.   +10 more
europepmc   +2 more sources

Synthetic Toll-Like Receptors for Control of Innate Immunity With Far-Red Light. [PDF]

Adv Sci (Weinh)
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Leopold AV, Verkhusha VV.
europepmc   +2 more sources

A TRIF-Independent Branch of TLR3 Signaling [PDF]

The Journal of Immunology, 2012
Abstract dsRNA is a common pathogen-associated molecular pattern that is recognized by cellular TLR3 and used by virus-infected cells to activate specific transcription factors and trigger induction of antiviral genes. In this article, we report a new branch of TLR3 signaling that does not lead to gene induction but affects many ...
Michifumi, Yamashita, Saurabh, Chattopadhyay, Volker, Fensterl, Ying, Zhang, Ganes C, Sen   +4 more
openaire   +2 more sources

Dissociation of TRIF bias and adjuvanticity

Vaccine, 2020
Toll-like receptors (TLRs), a family of "pattern recognition receptors," bind microbial and host-derived molecules, leading to intracellular signaling and proinflammatory gene expression. TLR4 is unique in that ligand-mediated activation requires the co-receptor myeloid differentiation 2 (MD2) to initiate two signaling cascades: the MyD88-dependent ...
Katharina Richard, Darren J. Perkins, Erin M. Harberts, Yang Song, Archana Gopalakrishnan, Kari Ann Shirey, Wendy Lai, Alexandra Vlk, Anup Mahurkar, Shreeram Nallar, Lynn D. Hawkins, Robert K. Ernst, Stefanie N. Vogel   +12 more
openaire   +3 more sources

TRIF, and TRIF-Interacting TLRs Differentially Modulate Several Adenovirus Vector-Induced Immune Responses [PDF]

Journal of Innate Immunity, 2009
The use of Adenovirus (Ad)-based vectors has proven to be a useful platform for the development of gene therapy and vaccine protocols. The immunological mechanisms underlying these properties need to be identified and understood to foster safer, more efficacious use of this important gene transfer platform.
D M, Appledorn, S, Patial, S, Godbehere, N, Parameswaran, A, Amalfitano   +4 more
openaire   +2 more sources