Results 11 to 20 of about 22,737 (222)

TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in MiceSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Toll-like receptor 4 (TLR4) signaling is activated through 2 adaptor proteins: MyD88 and TIR-domain containing adaptor-inducing interferon-β (TRIF).
Ling Yang, Kouichi Miura, Bi Zhang, Hiroshi Matsushita, Yoon Mee Yang, Shuang Liang, Jingyi Song, Yoon Seok Roh, Ekihiro Seki   +8 more
doaj   +7 more sources

Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance This study sheds light on the mechanisms of Toll-like receptor 4 (TLR4) signaling complex assembly. Particularly, the interaction site that mediates Toll/IL-1R resistance (TIR) domain–containing adapter-inducing IFN-β (TRIF) recruitment to the TLR4 signaling complex is identified within the second helical region of the ...
Piao, Wenji, Ru, Lisa W, Piepenbrink, Kurt H, Sundberg, Eric J, Vogel, Stefanie N, Toshchakov, Vladimir Y   +5 more
openaire   +4 more sources

TIR-Domain-Containing Adapter-Inducing Interferon-β (TRIF)-Dependent Antiviral Responses Protect Mice against Ross River Virus Disease

mBio, 2022
Ross River virus (RRV) is the major mosquito-borne virus in the South Pacific region. RRV infections are characterized by arthritic symptoms, which can last from several weeks to months.
Xiang Liu, Adam Taylor, Yee Suan Poo, Wern Hann Ng, Lara J. Herrero, Patrick Chun Hean Tang, Ali Zaid, Suresh Mahalingam   +7 more
doaj   +2 more sources

Proteomic analysis of TRIF interactome and functional characterisation of novel TRIF interacting proteins [PDF]

, 2012
Toll-like receptors (TLRs) are germline-encoded pattern-recognition receptors that initiate innate immune responses by recognising molecular structures shared by a wide range of pathogens, known as pathogen-associated molecular patterns (PAMPs). TIR domain-containing adaptor inducing IFN-β (TRIF) is an important adaptor protein in TLR3 and TLR4 ...
Ahmed, Suaad M.
core   +5 more sources

TRIF adaptor signaling is important in abdominal aortic aneurysm formation [PDF]

Atherosclerosis, 2015
Abdominal aortic aneurysm (AAA) is characterized by inflammation, loss of smooth muscle cells (SMCs), and degradation of the extracellular matrix in the vessel wall. Innate immune receptors such as Toll-like receptors (TLRs) were recently shown to regulate immunological processes leading to the formation and progression of atherosclerotic plaques as ...
Vorkapic, Emina, Lundberg, Anna M., Mayranpaa, Mikko I., Eriksson, Per, Wågsäter, Dick   +4 more
openaire   +5 more sources

TRIF Is a Critical Survival Factor in Viral Cardiomyopathy [PDF]

The Journal of Immunology, 2011
Abstract TRIF is a member of the innate immune system known to be involved in viral recognition and type I IFN activation. Because IFNs are thought to play an important role in viral myocarditis, we investigated the role of TRIF in induced myocarditis in mice.
Alexander, Riad, Dirk, Westermann, Christin, Zietsch, Konstantinos, Savvatis, Peter M, Becher, Stefan, Bereswill, Markus M, Heimesaat, Olga, Lettau, Dirk, Lassner, Andrea, Dörner, Wolfgang, Poller, Matthias, Busch, Stephan B, Felix, Heinz P, Schultheiss, Carsten, Tschöpe   +14 more
openaire   +3 more sources

TRIF Signaling Is Essential for TLR4-Driven IgE Class Switching [PDF]

The Journal of Immunology, 2014
Abstract The TLR4 ligand LPS causes mouse B cells to undergo IgE and IgG1 isotype switching in the presence of IL-4. TLR4 activates two signaling pathways mediated by the adaptor molecules MyD88 and Toll/IL-IR domain-containing adapter-inducing IFN-β (TRIF)–related adaptor molecule (TRAM), which recruits TRIF.
Janssen, Erin, Ozcan, Esra, Liadaki, Kyriaki, Jabara, Haifa H., Manis, John, Ullas, Sumana, Akira, Shizuo, Fitzgerald, Katherine A, Golenbock, Douglas T., Geha, Raif S.   +9 more
openaire   +4 more sources

Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway. [PDF]

PLoS Pathogens, 2018
Toll-like receptor 3 (TLR3) senses dsRNA intermediates produced during RNA virus replication to activate innate immune signaling pathways through adaptor protein TRIF.
Yisha Liang, Xuezhi Cao, Qiang Ding, Yanan Zhao, Zhenliang He, Jin Zhong   +5 more
doaj   +2 more sources

TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion.

PLoS ONE, 2013
Toll like receptor 4 (TLR4) is an important pattern recognition receptor with the ability to drive potent innate immune responses and also to modulate adaptive immune responses needed for long term protection.
Siva K Gandhapudi, Paula M Chilton, Thomas C Mitchell   +2 more
doaj   +2 more sources

Identification of a TLR4‐ and TRIF‐dependent activation program of dendritic cells [PDF]

European Journal of Immunology, 2004
AbstractDendritic cell activation by Toll‐like receptors (TLR) is crucial for the generation of protective immune responses. In addition to the common myeloid differentiation factor 88 (MyD88)‐dependent signaling pathway, TLR4 engages the adaptor protein Toll/IL‐1 receptor (TIR)‐domain‐containing adaptor inducing IFN‐β (TRIF), leading to interferon ...
Heike, Weighardt, Gabriela, Jusek, Jörg, Mages, Roland, Lang, Kasper, Hoebe, Bruce, Beutler, Bernhard, Holzmann   +6 more
openaire   +3 more sources