Results 1 to 10 of about 22,737 (222)

Inhibition of TRIF-Dependent Inflammation Decelerates Afterload-Induced Myocardial Remodeling [PDF]

Biomedicines, 2022
Pressure-overload-induced cardiac hypertrophy represents one cause of the development of heart failure. The aim of this study is to characterize the influence of the TIR-domain-containing adapter-inducing interferon-β (TRIF) during afterload-induced ...
Dominic Millenaar, Bruno Scheller
exaly   +6 more sources

The RHIM of the Immune Adaptor Protein TRIF Forms Hybrid Amyloids with Other Necroptosis-Associated Proteins

Molecules, 2022
TIR-domain-containing adapter-inducing interferon-β (TRIF) is an innate immune protein that serves as an adaptor for multiple cellular signalling outcomes in the context of infection. TRIF is activated via ligation of Toll-like receptors 3 and 4.
Yann Gambin, Emma Sierecki, Margaret Sunde   +2 more
exaly   +4 more sources

TRIF-dependent signaling and its role in liver diseases

Frontiers in Cell and Developmental Biology
TIR domain-containing adaptor inducing IFN-β (TRIF) is a crucial adaptor molecule downstream of toll-like receptors 3 (TLR3) and 4 (TLR4). TRIF directly binds to TLR3 through its TIR domain, while it associates with TLR4 indirectly through the bridge ...
Yu Jin
exaly   +5 more sources

Zfand5 terminates TLR3/4 signaling and necroptosis by targeting TRIF to the proteasome for degradation [PDF]

Cell Death and Disease
Toll-like receptors (TLRs) are central to host defense and tissue repair, yet dysregulated TLR signaling contributes to inflammatory and autoimmune diseases.
Wei-Ting Liao, Chia-Hsing Shen, Viriya Adhiguna Winarso, Yu-You Chen, Ke-Hsin Chen, Chun-Hsiang Chuang, En-Yi Liu, Miao-Hsien Wu, Chia-I Lien, Yu-Ching Chen, Ting-Yu Lai, Tsung-Hsien Chuang, Chih-Yuan Lee, Li-Chung Hsu   +13 more
doaj   +2 more sources

TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation. [PDF]

PLoS ONE, 2012
Toll-like receptors (TLRs) mediated immune response is crucial for combating pathogens and must be tightly controlled. Tripartite motif (TRIM) proteins are a family of proteins that is involved in a variety of biological and physiological processes. Some
Qinghua Xue, Zhuo Zhou, Xiaobo Lei, Xinlei Liu, Bin He, Jianwei Wang, Tao Hung   +6 more
doaj   +3 more sources

Cyprinus carpio TRIF Participates in the Innate Immune Response by Inducing NF-κB and IFN Activation and Promoting Apoptosis

Frontiers in Immunology, 2021
TRIF, an important adaptor downstream of Toll-like receptor signaling, plays a critical role in the innate immune response. In this study, the full-length coding sequence of TRIF from common carp (Cyprinus carpio L.) was cloned and characterized ...
Rongrong Liu, Xiaoye Liu, Meijiao Song, Yue Qi, Hua Li, Guiwen Yang, Shijuan Shan   +6 more
doaj   +1 more source

Surface immunogenic protein from Streptococcus agalactiae and Fissurella latimarginata hemocyanin are TLR4 ligands and activate MyD88- and TRIF dependent signaling pathways

Frontiers in Immunology, 2023
The development of vaccine adjuvants is of interest for the management of chronic diseases, cancer, and future pandemics. Therefore, the role of Toll-like receptors (TLRs) in the effects of vaccine adjuvants has been investigated.
Diego A. Díaz-Dinamarca, Diego A. Díaz-Dinamarca, Diego A. Díaz-Dinamarca, Michelle L. Salazar, Daniel F. Escobar, Byron N. Castillo, Bastián Valdebenito, Pablo Díaz, Augusto Manubens, Fabián Salazar, Fabián Salazar, Fabián Salazar, Mayarling F. Troncoso, Sergio Lavandero, Sergio Lavandero, Janepsy Díaz, María Inés Becker, María Inés Becker, Abel E. Vásquez, Abel E. Vásquez   +19 more
doaj   +1 more source

Neurosteroid [3α,5α]-3-hydroxy-pregnan-20-one enhances IL-10 production via endosomal TRIF-dependent TLR4 signaling pathway

Frontiers in Endocrinology, 2023
BackgroundPrevious studies demonstrated the inhibitory effect of allopregnanolone (3α,5α-THP) on the activation of inflammatory toll-like receptor 4 (TLR4) signals in RAW264.7 macrophages and the brains of selectively bred alcohol-preferring (P) rats. In
Irina Balan, Adelina Grusca, Todd K. O’Buckley, A. Leslie Morrow, A. Leslie Morrow, A. Leslie Morrow   +5 more
doaj   +1 more source

Multiple Porcine Innate Immune Signaling Pathways Are Involved in the Anti-PEDV Response

Viruses, 2023
Porcine epidemic diarrhea virus (PEDV) has caused great damage to the global pig industry. Innate immunity plays a significant role in resisting viral infection; however, the exact role of innate immunity in the anti-PEDV response has not been fully ...
Youwen Zhang, Yulin Xu, Sen Jiang, Shaohua Sun, Jiajia Zhang, Jia Luo, Qi Cao, Wanglong Zheng, François Meurens, Nanhua Chen, Jianzhong Zhu   +10 more
doaj   +1 more source

TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Is Involved in Glucose Metabolism in Adipose Tissue through the Insulin/AKT Signaling Pathway

International Journal of Endocrinology, 2020
Obesity significantly increases the risk of developing type 2 diabetes mellitus and other metabolic diseases. Obesity is associated with chronic low-grade inflammation in white adipose tissues, which is thought to play an essential role in developing ...
Junling Yang, Ken-Ichiro Fukuchi
doaj   +1 more source