Results 51 to 60 of about 11,599 (170)

Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathwaysResearch in context

EBioMedicine, 2019
Background: We previously demonstrated the gut microbes-derived metabolite trimethylamine N-oxide (TMAO) could activate the atrial autonomic ganglion plexus and promote atrial arrhythmia. The cardiac sympathetic nervous system (CSNS) play important roles
Guannan Meng, Xiaoya Zhou, Menglong Wang, Liping Zhou, Zhenya Wang, Meng Wang, Jielin Deng, Yuhong Wang, Zhen Zhou, Yifeng Zhang, Yanqiu Lai, Qianqian Zhang, Xiaomeng Yang, Lilei Yu, Hong Jiang   +14 more
doaj   +1 more source

Detection of the UV-vis silent biomarker trimethylamine-N-oxide via outer-sphere interactions in a lanthanide metal-organic framework

Communications Chemistry, 2022
Detection of trimethylamine N-oxide (TMAO) can allow for early intervention of cardiovascular disease, but is challenging to achieve using conventional materials and instruments owing to it being spectroscopically silent in the UV-visible region. Here, a
Hui Min, Zhonghang Chen, Zongsu Han, Kunyu Wang, Jun Xu, Wei Shi, Peng Cheng   +6 more
doaj   +1 more source

Structure‐Property Relationships in Catecholamine Coatings for Broad Surface Functionalization

Advanced Functional Materials, EarlyView.
Inspired by mussel adhesive proteins (MAPs), six catecholamine molecules with different molecular structure were systematically characterized and compared based on their ability to form homogeneous, reactive coatings. Highlighting candidates capable of balancing coating properties of interest, their successful use as primer layers for organic and ...
Caroline F. Harms, Qiming Li, Ye‐Sol Kim, Anish Tuteja, Jinsang Kim, Abdon Pena‐Francesch   +5 more
wiley   +1 more source

Advanced In Vitro Platforms for Experimental Liver Research: From Organoids and Liver‐on‐Chip to Omics and Artificial Intelligence

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hepatocytes perform essential physiological functions in the human body. Gaining more profound insight into the liver structure, diseases, and physiology by using in vitro models can help to propose more relevant clinical applications. Conventional in vitro liver models, such as two‐dimensional (2D) cell cultures, fail to adequately replicate ...
Seyedeh Kiana Teymorian, Pedram Asadi Sarabi, Abbas Piryaei, Massoud Vosough   +3 more
wiley   +1 more source

Trimethylamine N-Oxide Generated by the Gut Microbiota Is Associated with Vascular Inflammation: New Insights into Atherosclerosis

Mediators of Inflammation, 2020
Trimethylamine N-oxide (TMAO) is a biologically active molecule generated by the gut microbiota. Accumulating evidences have indicated a close association between high plasma TMAO levels and the risk of developing atherosclerosis (AS). AS is considered a
Yarong Liu, Min Dai
doaj   +1 more source

The relationship between trimethylamine-N-oxide and the risk of acute ischemic stroke: A dose‒response meta-analysis.

PLoS ONE, 2023
BackgroundAlthough trimethylamine-N-oxide (TMAO) shows a notable correlation with cardiovascular disease, its association with acute ischemic stroke (AIS) remains uncertain and necessitates further investigation.ObjectiveA meta-analysis was conducted to ...
Yuan Hong, Zaidie Sun, Nianqiu Liu, Kai Yang, Ya Li, Qiuyue Xu, Zhangyou Guo, Yong Duan   +7 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target [PDF]

Nutrients, 2018
Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several factors including diet, gut microbial flora, drug administration and liver flavin monooxygenase activity.
Manuel Janeiro, María Ramírez, Fermin Milagro, J. Martínez, Maite Solas   +4 more
openaire   +4 more sources

Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism

mBio
Anaerobic metabolism of dietary choline to trimethylamine (TMA) by the human gut microbiome is a disease-associated pathway. The host’s impaired ability to oxidize TMA to trimethylamine-N-oxide (TMAO) results in trimethylaminuria (TMAU), while elevated ...
Amelia Y. M. Woo, Walter J. Sandoval-Espinola, Maud Bollenbach, Alison Wong, Mariko Sakanaka-Yokoyama, Qijun Zhang, Vincent Nieto, Federico E. Rey, Emily P. Balskus   +8 more
doaj   +1 more source