Results 31 to 40 of about 11,599 (170)

Trimethylamine N-oxide (TMAO) Is not Associated with Cardiometabolic Phenotypes and Inflammatory Markers in Children and Adults. [PDF]

Curr Dev Nutr, 2021
Trimethylamine N-oxide (TMAO) is a diet- and microbiome-derived metabolite and a proposed biomarker of adverse cardiometabolic outcomes. TMAO studies have mainly been conducted in individuals with cardiometabolic disease, and studies in population-derived samples are limited.We aimed to investigate the associations between plasma TMAO concentrations ...
Andraos S, Jones B, Lange K, Clifford SA, Thorstensen EB, Kerr JA, Wake M, Saffery R, Burgner DP, O'Sullivan JM.   +9 more
europepmc   +5 more sources

Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis

Frontiers in Cardiovascular Medicine, 2022
Atherosclerosis (AS) is one of the most common cardiovascular diseases (CVDs), and there is currently no effective drug to reverse its pathogenesis. Trimethylamine N-oxide (TMAO) is a metabolite of the gut flora with the potential to act as a new risk ...
Lele Jing, Honghong Zhang, Qiannan Xiang, Liang Shen, Xiaoxia Guo, Changlin Zhai, Huilin Hu   +6 more
doaj   +1 more source

Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

JCI Insight, 2023
We determined whether gut microbiota-produced trimethylamine (TMA) is oxidized into trimethylamine N-oxide (TMAO) in nonliver tissues and whether TMAO promotes inflammation via trained immunity (TI).
Fatma Saaoud, Lu Liu, Keman Xu, Ramon Cueto, Ying Shao, Yifan Lu, Yu Sun, Nathaniel W. Snyder, Sheng Wu, Ling Yang, Yan Zhou, David L. Williams, Chuanfu Li, Laisel Martinez, Roberto I. Vazquez-Padron, Huaqing Zhao, Xiaohua Jiang, Hong Wang, Xiaofeng Yang   +18 more
doaj   +1 more source

Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism [PDF]

Lipids in Health and Disease, 2018
Recently, trimethylamine-N-oxide (TMAO) plasma levels have been proved to be associated with atherosclerosis development. Among the targets aimed to ameliorating atherosclerotic lesions, inducing bile acid synthesis to eliminate excess cholesterol in body is an effective way.
Lin Ding, Mengru Chang, Ying Guo, Lingyu Zhang, Changhu Xue, Teruyoshi Yanagita, Tiantian Zhang, Yuming Wang   +7 more
openaire   +3 more sources

Trimethylamine N-Oxide (TMAO) and Indoxyl Sulfate Concentrations in Patients with Alcohol Use Disorder

Nutrients, 2022
Background: Trimethylamine N-oxide (TMAO) and indoxyl sulfate (IS) are produced by the microbiota and the liver, and can contribute to brain aging and impaired cognitive function. This study aims to examine serum TMAO and IS concentrations in patients with alcohol-use disorder (AUD) at the entry for alcohol withdrawal, and the relationships with ...
Coulbault, Laurent, Laniepce, Alice, Segobin, Shailendra, Boudehent, Céline, Cabé, Nicolas, Pitel, Anne   +5 more
openaire   +4 more sources

Research advances of trimethylamine N-oxide and chronic kidney diseases

Linchuang shenzangbing zazhi, 2021
Trimethylamine N-oxide（TMAO）is an important gut microbiota-dependent metabolite.Currently many clinical studies have confirmed the correlation between TMAO and the prognosis of chronic kidney disease（CKD）patients.This review summarized the latest ...
Liu Mei-jun, Zhou Wen-hua, Zhao Jing, Cui Wen-Peng   +3 more
doaj  

Fecal Microbiome Composition Does Not Predict Diet‐Induced TMAO Production in Healthy Adults

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Trimethylamine‐N‐oxide (TMAO) is a small molecule derived from the metabolism of dietary nutrients by gut microbes and contributes to cardiovascular disease. Plasma TMAO increases following consumption of red meat.
Marc Ferrell, Peter Bazeley, Zeneng Wang, Bruce S. Levison, Xinmin S. Li, Xun Jia, Ronald M. Krauss, Rob Knight, Aldons J. Lusis, J. C. Garcia‐Garcia, Stanley L. Hazen, W. H. Wilson Tang   +11 more
doaj   +1 more source

Protonation of trimethylamine N-oxide (TMAO) is required for stabilization of RNA tertiary structure [PDF]

Biophysical Chemistry, 2013
The osmolyte trimethylamine N-oxide (TMAO) stabilizes the tertiary but not the secondary structures of RNA. However, molecular dynamics simulations performed on the PreQ1 riboswitch showed that TMAO destabilizes the tertiary riboswitch structure, leading us to hypothesize that the presence of RNA could result in enhanced population of the protonated ...
Elizabeth J, Denning, D, Thirumalai, Alexander D, MacKerell   +2 more
openaire   +2 more sources

Effect of urea and tmao on lipid bilayers

European Pharmaceutical Journal, 2017
We study the effect of the osmolytes, Urea and trimethylamine-N-oxide (TMAO) on POPE (1-palmitoyl-2-oleoyl-sn-glycero-3- phosphoethanolamine) lipid membranes using SAXS/WAXS and DSC.
Valerio J., Bernstorff S., Funari S.S.
doaj   +1 more source

Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease [PDF]

Scientific Reports, 2019
AbstractPeripheral artery disease (PAD) is a major cause of acute and chronic illness, with extremely poor prognosis that remains underdiagnosed and undertreated. Trimethylamine-N-Oxide (TMAO), a gut derived metabolite, has been associated with atherosclerotic burden.
Carmen Roncal, Esther Martínez-Aguilar, Josune Orbe, Susana Ravassa, Alejandro Fernandez-Montero, Goren Saenz-Pipaon, Ana Ugarte, Ander Estella-Hermoso de Mendoza, Jose A. Rodriguez, Sebastián Fernández-Alonso, Leopoldo Fernández-Alonso, Julen Oyarzabal, Jose A. Paramo   +12 more
openaire   +3 more sources