Results 21 to 30 of about 11,599 (170)

The ability of trimethylamine N-oxide to resist pressure induced perturbations to water structure

Communications Chemistry, 2022
Trimethylamine N-oxide (TMAO) protects organisms from the damaging effects of deep-sea high pressure, but it is not well understood how pressure and TMAO in combination perturb the water structure.
Harrison Laurent, Tristan G. A. Youngs, Thomas F. Headen, Alan K. Soper, Lorna Dougan   +4 more
doaj   +1 more source

Gut Microbiota and Ischemic Stroke: The Role of Trimethylamine N-Oxide [PDF]

Journal of Stroke, 2019
Trimethylamine N-oxide (TMAO) is produced when trimethylamine, a waste product of gut microbes, is converted via hepatic flavin monooxygenases. As TMAO is a potential causative factor in various cardiovascular diseases (CVDs) considerable research ...
Hyo Suk Nam
doaj   +1 more source

Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO) [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance The ability of trimethylamine N-oxide (TMAO) to counteract osmotic stress along with the deleterious effects of denaturants such as urea is fascinating and has inspired many studies. To further our understanding of how TMAO acts to stabilize folded proteins, we carry out an infrared experiment designed to probe the ...
Jianqiang, Ma, Ileana M, Pazos, Feng, Gai   +2 more
openaire   +2 more sources

Rapid Detection of Gut Microbial Metabolite Trimethylamine N-Oxide for Chronic Kidney Disease Prevention

Biosensors, 2021
The gut microbiota plays a critical role in chronic kidney disease (CKD) and hypertension. Trimethylamine-N-oxide (TMAO) and trimethylamine (TMA) are gut microbiota-derived metabolites, and both are known uraemic toxins that are implicated in CKD ...
Yu-Chun Chang, Yi-Hsuan Chu, Chien-Cheng Wang, Chih-Hsuan Wang, You-Lin Tain, Hung-Wei Yang   +5 more
doaj   +1 more source

Identification and characterization of trimethylamine N-oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2. [PDF]

Environmental microbiology, 2014
Methylocella silvestris, an alphaproteobacterium isolated from a forest soil, can grow on trimethylamine N-oxide (TMAO) as a sole nitrogen source; however, the molecular and biochemical mechanisms underpinning its growth remain unknown. Marker-exchange mutagenesis enabled the identification of several genes involved in TMAO metabolism, including ...
Zhu, Yijun , Jameson, Eleanor, Parslow, Rosemary A., Lidbury, Ian, Fu, Tiantian, Dafforn, Tim, Schäfer, Hendrik, Chen, Yin   +7 more
openaire   +2 more sources

TMAO metaorganismal pathway and chronic inflammatory diseases [PDF]

Exploration of Medicine
Nutrients containing a trimethylamine (TMA) moiety in their structure can be metabolized by the gut microbiota through enzymatic cleavage of the C-N bond, producing TMA.
Zeneng Wang, Shumei Man, Robert Koeth
doaj   +1 more source

Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation

npj Biofilms and Microbiomes, 2022
Cardiovascular disease (CVD) is strongly associated with the gut microbiota and its metabolites, including trimethylamine-N-oxide (TMAO), formed from metaorganismal metabolism of ʟ-carnitine.
Suraphan Panyod, Wei-Kai Wu, Pei-Chen Chen, Kent-Vui Chong, Yu-Tang Yang, Hsiao-Li Chuang, Chieh-Chang Chen, Rou-An Chen, Po-Yu Liu, Ching-Hu Chung, Huai-Syuan Huang, Angela Yu-Chen Lin, Ting-Chin David Shen, Kai-Chien Yang, Tur-Fu Huang, Cheng-Chih Hsu, Chi-Tang Ho, Hsien-Li Kao, Alexander N. Orekhov, Ming-Shiang Wu, Lee-Yan Sheen   +20 more
doaj   +1 more source

Ethnic differences in association of outcomes with trimethylamine N‐oxide in acute heart failure patients

ESC Heart Failure, 2020
Aims The aim of this study was to investigate whether ethnicity influences the associations between trimethylamine N‐oxide (TMAO) levels and heart failure (HF) outcomes.
Yoshiyuki Yazaki, Kenichi Aizawa, Muhammad Zubair Israr, Keita Negishi, Andrea Salzano, Yuka Saitoh, Natsuka Kimura, Ken Kono, Liam Heaney, Shabana Cassambai, Dennis Bernieh, Florence Lai, Yasushi Imai, Kazuomi Kario, Ryozo Nagai, Leong L. Ng, Toru Suzuki   +16 more
doaj   +1 more source

Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans [PDF]

Scientific Reports, 2016
AbstractCirculating trimethylamine N-Oxide (TMAO) levels predict cardiovascular disease (CVD), possibly by impacting on cholesterol metabolism and oxidative stress. Because hepatic TMAO production is regulated by insulin signalling and it is unclear whether and to what extent circulating TMAO levels associate with CVD risk, independently of insulin ...
Randrianarisoa, E., Lehn-Stefan, A., Wang, X., Hoene, M., Peter, A., Heinzmann, S.S., Zhao, X., Königsrainer, I., Königsrainer, A., Balletshofer, B., Machann, J., Schick, F., Fritsche, A., Häring, H.-U., Xu, G., Lehmann, R., Stefan, N.   +16 more
openaire   +4 more sources

Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N‐oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine.
Chelsea L. Organ, Zhen Li, Thomas E. Sharp, David J. Polhemus, Nilaksh Gupta, Traci T. Goodchild, W. H. Wilson Tang, Stanley L. Hazen, David J. Lefer   +8 more
doaj   +1 more source