Results 41 to 50 of about 11,599 (170)

Is Ergothioneine an Important Source of Plasma Trimethylamine N-Oxide in Humans?

Antioxidants
High circulating levels of trimethylamine-N-oxide (TMAO), largely produced by hepatic oxidation of gut-microbiota-derived trimethylamine (TMA), are associated with increased risk of cardiometabolic and neurodegenerative diseases.
Irwin K. Cheah, Lik Hang Wu, Richard M. Y. Tang, Ulrike Rieprecht, Leroy Sivappiragasam Pakkiri, Arthur Mark Richards, Chester Lee Drum, Barry Halliwell   +7 more
doaj   +1 more source

Trimethylamine N-Oxide and Related Metabolites in the Serum and Risk of Type 2 Diabetes in the Chinese Population: A Case-Control Study

Diabetes, Metabolic Syndrome and Obesity, 2023
Shenghong Qi,1,2 Lan Liu,1,2 Shulan He,1,2 Liqun Wang,1,2 Jiangping Li,1,2 Xian Sun1,2 1School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2The Key Laboratory of Environmental Factors and ...
Qi S, Liu L, He S, Wang L, Li J, Sun X
doaj  

An Expanded Genetic Code Enables Trimethylamine Metabolism in Human Gut Bacteria

mSystems, 2020
Cardiovascular disease (CVD) has been linked to animal-based diets, which are a major source of trimethylamine (TMA), a precursor of the proatherogenic compound trimethylamine-N-oxide (TMAO).
Veronika Kivenson, Stephen J. Giovannoni
doaj   +1 more source

Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke

Frontiers in Neurology, 2023
Ischemic stroke is by far the most common cerebrovascular disease and a major burden to the global economy and public health. Trimethylamine-N-oxide (TMAO), a small molecule compound produced by the metabolism of intestinal microorganisms, is reportedly ...
Yuan Liu, Juan Qu, Junjie Xu, Aiming Gu, Dezhi Deng, Xiaodan Jia, Baoxiang Wang   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase

eLife
Substrate channeling enhances efficiency and prevents toxicity by directing unstable intermediates between active sites. Trimethylamine N-oxide demethylase (TDM) degrades trimethylamine N-oxide (TMAO) to dimethylamine and formaldehyde (HCHO), but the ...
Trung Thach, KanagaVijayan Dhanabalan, Shiwangi Maurya, Yu Han-Hallett, Senwei Quan, Jane Allison, Gurunath Ramanathan, Ramaswamy Subramanian   +7 more
doaj   +1 more source

Gut microbe-derived metabolite trimethylamine N-oxide activates PERK to drive fibrogenic mesenchymal differentiation

iScience, 2022
Summary: Intestinal dysbiosis is prominent in systemic sclerosis (SSc), but it remains unknown how it contributes to microvascular injury and fibrosis that are hallmarks of this disease.
Seok-Jo Kim, Swarna Bale, Priyanka Verma, Qianqian Wan, Feiyang Ma, Johann E. Gudjonsson, Stanley L. Hazen, Paul W. Harms, Pei-Suen Tsou, Dinesh Khanna, Lam C. Tsoi, Nilaksh Gupta, Karen J. Ho, John Varga   +13 more
doaj   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

Investigating the Trimethylamine N-Oxide (TMAO) Induced Structure of α-Synuclein [PDF]

Biophysical Journal, 2015
Trimethylamine N-oxide (TMAO) is a naturally occurring osmolyte that is known to stabilize protein structure. Previous studies have shown that the addition of TMAO can induce folding of thermodynamically unstable proteins, causing them to regain high functional activity. In solution, monomeric α-synuclein (αS) is intrinsically disordered.
Ferrie, John J., Wissner, Rebecca F., Petersson, E James   +2 more
openaire   +1 more source

Longitudinal metabolomics reveals dynamic associations of trimethylamine N-oxide and precursors with the progression of gestational diabetes

BMC Pregnancy and Childbirth
Background Trimethylamine N-oxide (TMAO) and its precursor metabolites are strongly linked to glucose and lipid metabolic disorders, yet their dynamic roles and overall effects in gestational diabetes mellitus (GDM) have not been clarified.
Yuwen Wu, Zheng Ni, Shuo Liu, Sijia Fang, Yue Li, Qiuhan Lu, Dewei Ye, Shufei Zang, Guozhi Jiang   +8 more
doaj   +1 more source