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Silencing of tripartite motif protein (TRIM) 5α mediated anti-HIV-1 activity by truncated mutant of TRIM5αopenaire
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Role of the tripartite motif (TRIM) family in female genital neoplasms
Pathology - Research and Practice, 2023The tripartite motif proteins (TRIMs) family represents a class of highly conservative proteins which play a large regulatory role in molecular processes. Recently, increasing evidence has demonstrated a role of TRIMs in female genital neoplasms. Our review thereby aimed to provide an overview of the biological involvement of TRIMs in female genital ...
Tianyu Liu +7 more
openaire +2 more sources
Fish antiviral tripartite motif (TRIM) proteins
Fish & Shellfish Immunology, 2019Tripartite motif (TRIM) family or RBCC proteins comprises characteristic zinc-binding domains (a RING (R), a B-box type 1 (B1) and a B-box type 2 (B2)) and coiled-coil (CC) domain followed by a C-terminus variable domain. There are about 80 different TRIM proteins in human, but more than 200 in zebrafish with several large gene expansions (ftr >70 ...
Langevin, Christelle +2 more
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Diabetes, Obesity and Metabolism, 2023
Abstract Emerging evidence suggests that the ubiquitin‐mediated degradation of insulin‐signalling‐related proteins may be involved in the development of insulin resistance and its related disorders. Tripartite motif‐containing (TRIM) proteins, a superfamily belonging to the E3 ubiquitin ligases, are capable of controlling protein ...
Jianrong Chen +3 more
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Abstract Emerging evidence suggests that the ubiquitin‐mediated degradation of insulin‐signalling‐related proteins may be involved in the development of insulin resistance and its related disorders. Tripartite motif‐containing (TRIM) proteins, a superfamily belonging to the E3 ubiquitin ligases, are capable of controlling protein ...
Jianrong Chen +3 more
openaire +2 more sources
Investigating Antiviral Tripartite Motif (TRIM) Proteins in the Duck
2022Ducks are the natural host and reservoir of influenza A virus (IAV). It is currently unknown how ducks can both tolerate and restrict IAV replication. It is likely that ducks have evolved unique transcriptional responses to IAV infection to restrict virus while limiting damage from inflammation, however this is poorly understood. Here we examine global
openaire +1 more source
Xenotransplantation, 2020
AbstractBackgroundUnderstanding the interactions between the microRNA (miRNA) and mRNA of genes encoding restriction factors (RFs) can lead to the development of new antiretroviral strategies aimed at providing the resistance and reducing susceptibility of human cells to potential PERV infection.
Morawiec Emilia +5 more
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AbstractBackgroundUnderstanding the interactions between the microRNA (miRNA) and mRNA of genes encoding restriction factors (RFs) can lead to the development of new antiretroviral strategies aimed at providing the resistance and reducing susceptibility of human cells to potential PERV infection.
Morawiec Emilia +5 more
openaire +2 more sources
Increased expression of tripartite motif (TRIM) like 2 promotes tumoral growth in human oral cancer
Biochemical and Biophysical Research Communications, 2019Tripartite motif family-like 2 (TRIML2), a member of the TRIM proteins family, is closely related to Alzheimer's disease, however, no studies of TRIML2 have been published in the cancer research literature. In the current study, we investigated the expression level of TRIML2 and its molecular mechanisms in human oral squamous cell carcinoma (OSCC ...
Fumihiko, Hayashi +9 more
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Amino Acids, 2009
Viral tropism, replication, and pathogenesis are determined by multiple interactions between the pathogen and the host. In the case of retroviruses, and in particular, the human immunodeficiency virus, the specific interaction of the envelope protein with the host receptors and co-receptors is essential to gain entry in the cells.
Anna, Kajaste-Rudnitski +5 more
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Viral tropism, replication, and pathogenesis are determined by multiple interactions between the pathogen and the host. In the case of retroviruses, and in particular, the human immunodeficiency virus, the specific interaction of the envelope protein with the host receptors and co-receptors is essential to gain entry in the cells.
Anna, Kajaste-Rudnitski +5 more
openaire +2 more sources
Clinical Genitourinary Cancer, 2016
Many prognostic biomarkers associated with androgen signaling have been proposed in PC. The role of tripartite motif (TRIM) proteins remains unclear in PC. We investigated TRIM protein 47 (TRIM47) expression levels in human prostate tissues.We performed immunohistochemistry using original TRIM47 antibody in prostate tissues obtained by radical ...
Tetsuya, Fujimura +9 more
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Many prognostic biomarkers associated with androgen signaling have been proposed in PC. The role of tripartite motif (TRIM) proteins remains unclear in PC. We investigated TRIM protein 47 (TRIM47) expression levels in human prostate tissues.We performed immunohistochemistry using original TRIM47 antibody in prostate tissues obtained by radical ...
Tetsuya, Fujimura +9 more
openaire +2 more sources
Journal of Virological Methods, 2008
Tripartite motif protein (TRIM) 5alpha is a restriction factor of human immunodeficiency virus type 1 in Old World monkey cell. It was found that both naturally occurring and artificial TRIM5alpha variants lacking the SPRY domain could silence TRIM5alpha activity.
Hikoichiro, Maegawa +3 more
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Tripartite motif protein (TRIM) 5alpha is a restriction factor of human immunodeficiency virus type 1 in Old World monkey cell. It was found that both naturally occurring and artificial TRIM5alpha variants lacking the SPRY domain could silence TRIM5alpha activity.
Hikoichiro, Maegawa +3 more
openaire +2 more sources