Results 61 to 70 of about 4,709 (168)

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, EarlyView.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

TRIM-endous functional network of tripartite motif 29 (TRIM29) in cancer progression and beyond

Cancer and Metastasis Reviews
While most Tripartite motif (TRIM) family proteins are E3 ubiquitin ligases, some members have functions beyond the regulation of ubiquitination, impacting normal physiological processes and disease progression. TRIM29, an important member of the TRIM family, exerts a predominant influence on cancer growth, epithelial-to-mesenchymal transition ...
Wu, Qitong, Nandi, Deeptashree, Sharma, Dipali   +2 more
openaire   +2 more sources

Exploring TRIM proteins’ role in antiviral defense against influenza A virus and respiratory coronaviruses

Frontiers in Cellular and Infection Microbiology
Numerous tripartite motif (TRIM) proteins, identified as E3 ubiquitin ligases, participate in various viral infections through ubiquitylation, ISGylation, and SUMOylation processes.
Ying Wei, Ying Wei, Ying Wei, Junzhu Song, Junzhu Song, Junzhu Song, Jingyu Zhang, Jingyu Zhang, Jingyu Zhang, Songbiao Chen, Songbiao Chen, Songbiao Chen, Zuhua Yu, Zuhua Yu, Zuhua Yu, Lei He, Lei He, Lei He, Jian Chen, Jian Chen, Jian Chen   +20 more
doaj   +1 more source

Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor‐like lectin

The FEBS Journal, EarlyView.
We characterize the PLTL lectin from Photorhabdus laumondii, which adopts a unique TNF‐like fold. Binding assays reveal a preference for branched histo‐blood group oligosaccharides. Protein crystallography uncovers a novel hexameric assembly and identifies key residues involved in carbohydrate recognition.
Filip Melicher, Pavel Dobeš, Jan Komárek, Lukáš Faltinek, Marek Korsák, Petra Sýkorová, Josef Houser, Michaela Wimmerová   +7 more
wiley   +1 more source

Intentionalism, anti‐Intentionalism and conversational interaction

The Southern Journal of Philosophy, EarlyView.
Abstract Proponents as well as opponents of modeling aesthetic interpretation on conversation tend to assume that this implies that the author's intention constitutes the meaning of her work and that the aim of interpretation consists in recovering it.
Palle Leth
wiley   +1 more source

The TRIM (TRipartite Motif) Family as a Novel Class of Ubiquitin E3 Ligases [PDF]

, 2011
Proteins that belong to TRIM family are characterized by the presence of the tripartite motif module, composed of a RING domain, one or two B-box domains and a Coiled-coil region. TRIM proteins are involved in several cellular processes such as apoptosis, cell cycle regulation and viral response.
openaire   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish.

PLoS ONE, 2011
Tripartite motif proteins (TRIM) constitute a large family of proteins containing a RING-Bbox-Coiled Coil motif followed by different C-terminal domains. Involved in ubiquitination, TRIM proteins participate in many cellular processes including antiviral
Pierre Boudinot, Lieke M van der Aa, Luc Jouneau, Louis Du Pasquier, Pierre Pontarotti, Valérie Briolat, Abdenour Benmansour, Jean-Pierre Levraud   +7 more
doaj   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives

Frontiers in Cell and Developmental Biology
Intervertebral disc degeneration (IVDD) is a leading cause of chronic back pain, contributing significantly to reduced quality of life and global public health burdens.
Shangze Li, Wenli Jiang, Fei Chen, Jiao Qian, Jun Yang   +4 more
doaj   +1 more source