Results 91 to 100 of about 57,313 (306)

Preparation of Neurospora crassa mitochondria [PDF]

, 1978
The fungus Neurospora crassa represents a eukaryotic cell with high biosynthetic activities. Cell mass doubles in 2-4 hr during expone ntial growth , even in simple salt media with sucrose as the sole carbon source. The microorgani sm forms a mycelium of
Jacki, Klingenberg, Michel, Neupert, Sebald, Vogel, von Jagow, von Ruecker, Weiss, Weiss, Weiss, Werner   +11 more
core   +2 more sources

A Phase 1, Double‐Blind, Placebo‐Controlled Trial of Sevasemten (EDG‐5506), a Selective Modulator of Fast Skeletal Muscle Contraction, in Healthy Volunteers and Adults With Becker Muscular Dystrophy

Muscle &Nerve, Volume 72, Issue 3, Page 399-407, September 2025.
ABSTRACT Introduction/Aims Sevasemten (EDG‐5506) is an orally administered, investigational small molecule that selectively modulates fast muscle fiber contraction by inhibiting fast myosin ATPase. This study assessed the safety, tolerability, and pharmacokinetics (PK)/pharmacodynamics (PD) of sevasemten in healthy adult volunteers (HVs) and adults ...
Joanne Donovan, Jeffrey A. Silverman, Ben Barthel, Michael DuVall, Molly Madden, James MacDougall, Nicole Rempel Kilburn, Abby Bronson, Marc Evanchik, Gilad Gordon, Kevin Koch, Alan J Russell   +11 more
wiley   +1 more source

Copper-transporting P-type adenosine triphosphatase (ATP7A) is associated with platinum-resistance in non-small cell lung cancer (NSCLC)

Journal of Translational Medicine, 2012
Background Copper export protein ATP7A is important for maintaining copper homeostasis. Recent studies have shown that copper transporters are also involved in the transport of platinum.
Li Zhuang-hua, Qiu Miao-zhen, Zeng Zhao-lei, Luo Hui-yan, Wu Wen-jing, Wang Feng, Wang Zhi-qiang, Zhang Dong-sheng, Li Yu-hong, Xu Rui-hua   +9 more
doaj   +1 more source

Solving the Structure of eIF2 Bound to eIF2B Using Cryogenic Electron Microscopy [PDF]

, 2019
Translation begins when initiation factor-2 (eIF2) delivers methionyl initiator tRNA (Met-tRNAi) to the ribosome. The exchange of GDP bound to eIF2 for GTP is a prerequisite to binding Met-tRNAi and is mediated by a second initiation factor, eIF2B ...
Kenner, Lillian
core  

The competitive effect of adenosine-5'-triphosphate against the stimulating and inhibiting actions of 2,4-dinitrophenol on the mitochondrial respiration [PDF]

, 1969
Effect of ATP and substrates on 2,4-dinitrophenol-induced adenosine triphcsphatase (E. C. 3.6. 1. 4.) activity and respiration of isolated rat liver mitochondria has been investigated. 1.
Hatase, O., Oda, T., Yamamoto, G.
core   +1 more source

An Unusual Case of Cutaneous Langerhans Cell Sarcoma Lacking S100 Expression: A Case Report and Review of the Literature

Journal of Cutaneous Pathology, Volume 52, Issue 9, Page 554-567, September 2025.
ABSTRACT Langerhans cell sarcoma (LCS) is a rare neoplastic proliferation of Langerhans cell with aggressive clinical behavior and involves multiple organ systems, including the skin. LCS is characterized by marked cytologic atypia, frequent mitoses including atypical ones, and expression of CD1a, S100, and langerin (CD207).
Randa Obid, Austin R. Green, Sion W. Jasmine, Rachel P. Kowal, Brooj Abro, Laura M. Warmke, Magdalena B. Czader, Ahmed K. Alomari, Carina A. Dehner   +8 more
wiley   +1 more source

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]

, 2014
There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Ahn, Aitken, Alexander, Alexander, Batsché, Bentley, Buratowski, Carrillo Oesterreich, Chapman, Chen, Cho, Cordin, Cramer, Damgaard, Das, David, de Almeida, Dönmez, Edgar, Egloff, Fong, Furger, Görnemann, Hirose, J. David Barrass, Jean D. Beggs, Ji, Kameoka, Keerthi T. Chathoth, Komarnitsky, Kornblihtt, Kornblihtt, Kosowski, Lacadie, Levine, Li, Lin, McCracken, McKay, Miller, Moore, Orphanides, Perriman, Perriman, Perriman, Perriman, Pleiss, Ruby, Schmidt, Schneider, Schroeder, Shao, Shaun Webb, Singh, Tardiff, Wahl, Wells, Witten, Xu, Xu, Yan, Zavanelli, Zhou   +62 more
core   +1 more source

Quercetin Improves Lipopolysaccharide‐Induced Septic Liver Injury by Inhibiting the Activation of ROCK/NF‐κB/NLRP3 Pathway

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Quercetin has potential protective effects on sepsis liver injury (SLI) induced by lipopolysaccharide. Quercetin inhibits activation of the NLRP3 inflammasome in SLI liver. Quercetin suppresses Rho kinase/NF‐κB signaling in SLI liver. ABSTRACT Quercetin (QUE) is a common flavonoid compound, found in fruits and vegetables, with powerful anti ...
Lina Xiao, Lingya Kong, Ming Han, Jianing Zhao, Meini Zhang, Yanjin Li, Mingxuan Wang, Zirui Wang, Jiaxuan Li, Zhihong Ma, Zhuojun Deng   +10 more
wiley   +1 more source

Impact of ITPA gene polymorphism for predicting anemia and treatment outcome in HCV infected patients taking Sofosbuvir Ribavirin therapy

BMC Infectious Diseases
Background Globally, 80 million people are suffering from chronic Hepatitis C virus (HCV) infection. Sofosbuvir ribavirin-based anti-HCV therapy is associated with anemia and other adverse effects.
Sameen Amjed, Hafiz Ghulam Murtaza Saleem, Sajjad Ullah, Shahzad Latif, Shabana, Junaid Jafar, Ahmad Bilal Waqar   +6 more
doaj   +1 more source

Evaluation of sexual dimorphism of histochemical activity of phosphatases of the plantar glands of Norway rats (Rattus norvegicus)

Biosystems Diversity, 2019
The activity of acid phosphatase, alkaline phosphatase and adenosine triphosphatase in the eccrine and sebaceous glands of the skin of the soles of the paws of male and female Norway rats was studied by histochemiсal methods.
A. B. Kiladze, N. K. Dzhemukhadze
doaj   +1 more source