Results 91 to 100 of about 56,477 (262)

ITPA polymorphisms are associated with hematological side effects during antiviral therapy for chronic HCV infection [PDF]

, 2015
Background/Objective Genetic polymorphisms in the inosine triphosphatase (ITPA) gene have been associated with the protection from early ribavirin(RBV)-induced hemolytic anemia among patients with chronic hepatitis C virus (HCV) infection. The aim of the
Boonstra, P.A. (André), Brouwer, W.P. (Willem), Eijck, A.A. (Annemiek), Groothuismink, Z.M.A. (Zwier), Hansen, B.E. (Bettina), Janssen, H.L.A. (Harry), Knegt, R.J. (Robert) de, Maan, R. (Raoel), Meer, A.J.P. (Adriaan) van der, Plompen, E.P.C. (Elisabeth), Roomer, R. (Robert), Sonneveld, M.J. (Milan), Veldt, B.J. (Bart)   +12 more
core   +1 more source

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]

, 2014
There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Ahn, Aitken, Alexander, Alexander, Batsché, Bentley, Buratowski, Carrillo Oesterreich, Chapman, Chen, Cho, Cordin, Cramer, Damgaard, Das, David, de Almeida, Dönmez, Edgar, Egloff, Fong, Furger, Görnemann, Hirose, J. David Barrass, Jean D. Beggs, Ji, Kameoka, Keerthi T. Chathoth, Komarnitsky, Kornblihtt, Kornblihtt, Kosowski, Lacadie, Levine, Li, Lin, McCracken, McKay, Miller, Moore, Orphanides, Perriman, Perriman, Perriman, Perriman, Pleiss, Ruby, Schmidt, Schneider, Schroeder, Shao, Shaun Webb, Singh, Tardiff, Wahl, Wells, Witten, Xu, Xu, Yan, Zavanelli, Zhou   +62 more
core   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Regulation of Gastric Lgr5+ve Cell Homeostasis by Bone Morphogenetic Protein (BMP) Signaling and Inflammatory StimuliSummary

Cellular and Molecular Gastroenterology and Hepatology, 2018
Background & Aims: Gastric Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) cells exert important functions during injury and homeostasis.
Wei Ye, Hidehiko Takabayashi, Yitian Yang, Maria Mao, Elise S. Hibdon, Linda C. Samuelson, Kathryn A. Eaton, Andrea Todisco   +7 more
doaj   +1 more source

Disturbances of energy metabolism in the internal organs in traumatic cranial injury on the background of diabetes

Zaporožskij Medicinskij Žurnal, 2013
Traumatic cranial injury is one of the leading reasons in the statistics of mortality. Modern ideas about the pathogenesis of traumatic brain injury based on the allocation of primary and secondary factors of brain damage.
V. M. Meretskyі
doaj   +1 more source

Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]

, 2018
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel, Kasvandik, Sergo, Lulla, Aleksei, Lulla, Valeria, McInerney, Gerald M., Merits, Andres, Morro, Ainhoa Moliner, Mutso, Margit, Saul, Sirle, Smedberg, Cecilia, Tarve, Liisi, Teppor, Mona, Thaa, Bastian, Varjak, Margus   +13 more
core   +3 more sources

Comparative investigation of specific enzyme activities in the organs and tissues of the skin parasite Macrogyrodactylus congolensis (Monogenea: Gyrodactylidae)

Journal of Basic and Applied Zoology
Background Macrogyrodactylus congolensis is a pathogenic skin parasite that infects the economically important fish Clarias gariepinus. Little is known about the physiology and histochemistry of M. congolensis.
Safaa Zaky Arafa, El-Sayed Kasem Abd El-Hady, Samir Ahmed El-Abbassy   +2 more
doaj   +1 more source

The Impact of Plasmodium falciparum Adenosine Triphosphatase-6 Gene (PfATPase6) Mutations in Artemisinin Resistance

Journal of Pure and Applied Microbiology
The World Health Organization (WHO) recorded an estimated 263 million malaria cases globally in 2023, leading to about 597,000 mortalities. Most of this burden occurred in the WHO African Region, which accounted for approximately 94% of cases and 95% of ...
Obafemi Yemisi Dorcas, Atokolo Austine
doaj   +1 more source

A comparison of an ATPase from the archaebacterium Halobacterium saccharovorum with the F1 moiety from the Escherichia coli ATP Synthase [PDF]

A purified ATPase associated with membranes from Halobacterium saccharovorum was compared with the F sub 1 moiety from the Escherichia coli ATP Synthase.
Hochstein, Lawrence I., Stan-Lotter, Helga   +1 more
core   +1 more source

The Iron-Type Nitrile Hydratase Activator Protein Is A GTPase [PDF]

, 2017
The Fe-type nitrile hydratase activator protein from Rhodococcus equi TG328-2 (ReNHase TG328-2) was successfully expressed and purified. Sequence analysis and homology modeling suggest that it is a G3E P-loop guanosine triphosphatase (GTPase) within the ...
Bennett, Brian, Gumataotao, Natalie, Holz, Richard C., Wasantha Lankathilaka, Karunagala Pathiranage   +3 more
core   +1 more source