Results 21 to 30 of about 57,313 (306)
Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure [PDF]
Aims: Cellular processes in the heart rely mainly on studies from experimental animal models or explanted hearts from patients with terminal end-stage heart failure (HF).
Condorelli, Gianluigi+12 more
core +2 more sources
Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads [PDF]
Allosteric compounds that stimulate Hsp90 adenosine triphosphatase (ATPase) activity were rationally designed, showing anticancer potencies in the low micromolar to nanomolar range.
Agard, Da+10 more
core +1 more source
Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth
We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET.
Alexia Hervieu, Stéphanie Kermorgant
doaj +1 more source
Thyroid thermogenesis in adult rat hepatocytes in primary monolayer culture: direct action of thyroid hormone in vitro. [PDF]
We have studied the effect of 3,5,3'-triiodothyronine (T3) on the respiration of adult rat hepatocytes in primary monolayer culture prepared from hypothyroid rat liver. After addition of T3 to the culture medium at a concentration of 2 x 10(-7) M, oxygen
Bissell, DM+2 more
core +2 more sources
Yeast and Viral RNA 5′ Triphosphatases Comprise a New Nucleoside Triphosphatase Family [PDF]
Saccharomyces cerevisiae Cet1p catalyzes the first step of mRNA capping, the hydrolysis of the gamma phosphate of triphosphate-terminated RNA to form a 5' diphosphate end. The RNA triphosphatase activity of Cet1p is magnesium-dependent and has a turnover number of 1 s-1.
Stewart Shuman, Yi Pei, C. K. Ho
openaire +3 more sources
Objectives: To investigate whether postnatal benzo(a)pyrene (B(a)P) exposure caused the impairments on the process of neurodevelopment and the alteration in the calcium medium in the neonatal rats. Material and Methods: Eighty neonatal Sprague Dawley (SD)
Kai Yang+4 more
doaj +1 more source
The immunosuppressive agent mizoribine monophosphate is an inhibitor of the human RNA capping enzyme. [PDF]
Mizoribine monophosphate (MZP) is a specific inhibitor of the cellular inosine-5'-monophosphate dehydrogenase (IMPDH), the enzyme catalyzing the rate-limiting step of de novo guanine nucleotide biosynthesis.
Frédéric Picard-Jean+3 more
doaj +1 more source
The mechanism by which LED red light irradiation regulates postharvest banana ripening was evaluated in this study by the continuous irradiation of banana fruits at the mature-green stage.
Xinqun Zhou+8 more
doaj +1 more source
Inhibition and relaxation of sea urchin sperm flagella by vanadate [PDF]
Direct measurements of the stiffness (elastic bending resistance) of demembranated sera urchin sperm flagella were made in the presence of MgATP2- and vanadate.
Okuno, Makoto
core +3 more sources
Little is known about biochemical abnormalities which accompany or are responsible for the morphological changes which occur in the primary myopathies. A number of such diseases have been characterized in humans (Walton & Nattrass, 1954).
R. Pennington
semanticscholar +1 more source