Results 51 to 60 of about 289,605 (341)

Acinic cell carcinoma of the breast: A comprehensive review

Breast, 2022
Acinic cell carcinoma of the breast is a rare special subtype of breast cancer in the category of salivary gland-type tumors. It is morphologically similar to acinic cell carcinomas of salivary glands and pancreas and has a triple-negative phenotype ...
Azra Ajkunic, Faruk Skenderi, Nada Shaker, Saghir Akhtar, Janez Lamovec, Zoran Gatalica, Semir Vranic   +6 more
doaj   +1 more source

D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance PD-L1 is well known as an immune checkpoint molecule, which suppresses immune surveillance through binding to its receptor PD-1. Intracellular PD-L1 can also protect messenger RNAs of several DNA damage repair–related genes from degradation ...
Ruonan Zhang, Yajing Yang, Wenjing Dong, Mingen Lin, Jing He, Xinchao Zhang, Tongguan Tian, Yunlong Yang, Kun-Min Chen, Q. Lei, Song Zhang, Yanping Xu, Lei Lv   +12 more
semanticscholar   +1 more source

Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan.

PLoS ONE, 2011
Discrepancies in the prognosis of triple negative breast cancer exist between Caucasian and Asian populations. Yet, the gene signature of triple negative breast cancer specifically for Asians has not become available. Therefore, the purpose of this study
Lee H Chen, Wen-Hung Kuo, Mong-Hsun Tsai, Pei-Chun Chen, Chuhsing K Hsiao, Eric Y Chuang, Li-Yun Chang, Fon-Jou Hsieh, Liang-Chuan Lai, King-Jen Chang   +9 more
doaj   +1 more source

PPARα-Selective Antagonist GW6471 Inhibits Cell Growth in Breast Cancer Stem Cells Inducing Energy Imbalance and Metabolic Stress

Biomedicines, 2021
Breast cancer is the most frequent cancer and the second leading cause of death among women. Triple-negative breast cancer is the most aggressive subtype of breast cancer and is characterized by the absence of hormone receptors and human epithelial ...
Vanessa Castelli, Mariano Catanesi, Margherita Alfonsetti, Chiara Laezza, Francesca Lombardi, Benedetta Cinque, Maria Grazia Cifone, Rodolfo Ippoliti, Elisabetta Benedetti, Annamaria Cimini, Michele d’Angelo   +10 more
doaj   +1 more source

Sacituzumab Govitecan‐hziy in Refractory Metastatic Triple‐Negative Breast Cancer

New England Journal of Medicine, 2019
BACKGROUND Standard chemotherapy is associated with low response rates and short progression‐free survival among patients with pretreated metastatic triple‐negative breast cancer.
A. Bardia, I. Mayer, L. Vahdat, S. Tolaney, S. Isakoff, J. Diamond, J. O’Shaughnessy, R. Moroose, A. Santin, V. Abramson, N. Shah, H. Rugo, D. Goldenberg, A. Sweidan, R. Iannone, Sarah A. Washkowitz, R. Sharkey, W. Wegener, K. Kalinsky   +18 more
semanticscholar   +1 more source

Heterogeneity of triple negative breast cancer: Current advances in subtyping and treatment implications

Journal of experimental & clinical cancer research : CR, 2022
As the field of translational ‘omics has progressed, refined classifiers at both genomic and proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically-applicable way.
Karama Asleh, N. Riaz, T. Nielsen
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Identification and prognostic value of anterior gradient protein 2 expression in breast cancer based on tissue microarray

Tumor Biology, 2017
Breast cancer has attracted substantial attention as one of the major cancers causing death in women. It is crucial to find potential biomarkers of prognostic value in breast cancer. In this study, the expression pattern of anterior gradient protein 2 in
Jilong Guo, Guohua Gong, Bin Zhang
doaj   +1 more source

Methylseleninic acid enhances paclitaxel efficacy for the treatment of triple-negative breast cancer. [PDF]

PLoS ONE, 2012
A major challenge in breast cancer therapy is the lack of an effective therapeutic option for a particularly aggressive subtype of breast cancer, triple-negative breast cancer.
Yanfeng Qi, Xueqi Fu, Zhenggang Xiong, Haitao Zhang, Steven M Hill, Brian G Rowan, Yan Dong   +6 more
doaj   +1 more source

Triple-negative breast cancer: current treatment strategies and factors of negative prognosis

Journal of Medicine and Life, 2022
Breast cancer is the most common cancer in women and the most common cause of death in working-age women. According to the results of immunohistochemical studies, 10–20% of cases revealed a triple-negative type of breast cancer.
A. Baranova, M. Krasnoselskyi, V. Starikov, S. Kartashov, I. Zhulkevych, Vadym Vlasenko, K. Oleshko, Olga Bilodid, M. Sadchikova, Yurii Vinnyk   +9 more
semanticscholar   +1 more source