Results 161 to 170 of about 3,877 (200)

Control of mRNA decay by phosphorylation of tristetraprolin

Biochemical Society Transactions, 2008
TTP (tristetraprolin) is an RNA-binding protein that suppresses inflammation by accelerating the degradation of cytokine mRNAs. TTP binds to an AU-rich element in the 3′-untranslated region of its target mRNAs. In macrophages, the induction of cytokine expression requires activation of the p38-MAPK (mitogen-activated protein kinase)–MK2 [MAPKAP (MAPK ...
Heike, Sandler, Georg, Stoecklin
openaire   +2 more sources

Biofilm Biomimetic miR-29a Nanoparticles Inhibit Prostate Cancer Progression via Tristetraprolin/HuR-AR

Journal of Biomedical Nanotechnology, 2023
Prostate cancer (PCa) occupies the second place among all male malignancies worldwide. Our study explored therapeutic mechanism of biofilm biomimetic nanoparticles encapsulating miR-29a on PCa. The expression and location of HuR and Androgen Receptor (AR)
Hongwei Li, Zhan Gao, Zhiqiang Cui, Cezheng Wang   +3 more
semanticscholar   +1 more source

Salbutamol increases tristetraprolin expression in macrophages

Life Sciences, 2007
Tristetraprolin (TTP) is a tandem zinc finger protein that can bind to AU-rich elements (AREs) in the 3'-untranslated regions (3'-UTR) in mRNAs of transiently expressed genes, e.g. tumor necrosis factor-alpha (TNF-alpha) and granulocyte macrophage colony-stimulating factor (GM-CSF). TTP increases the turnover rate of the target mRNAs, thereby reducing,
Ulla, Jalonen, Tiina, Leppänen, Hannu, Kankaanranta, Eeva, Moilanen   +3 more
openaire   +2 more sources

Expansion of Interleukin‐22‐Producing Type 3 Innate Lymphoid Cells in the Gut of Tristetraprolin‐Deficient Mice

European Journal of Immunology
Tristetraprolin (TTP, encoded by Zfp36) is an RNA‐binding protein that plays a major role in the control of inflammation. Zfp36−/− mice spontaneously develop a complex multiorgan inflammatory syndrome but no overt intestinal inflammation, suggesting the ...
Bérengère de de Toeuf, Maxime Melchior, Caroline La, Aresio Villanueva Alcantara, Abdulkader Azouz, Vincent Martens, Céline La, Ingrid Dubois, Sylvie Vande Velde, Lara Meyer, Muriel Nguyen, Séverine Thomas, F. Libert, Laure Dumoutier, P. J. Blackshear, S. Goriely   +15 more
semanticscholar   +1 more source

Tristetraprolin posttranscriptionally downregulates PFKFB3 in cancer cells

Biochemical and Biophysical Research Communications, 2020
The enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases 3 (PFKFB3) catalyzes the first committed rate-limiting step of glycolysis and is upregulated in cancer cells. The mechanism of PFKFB3 expression upregulation in cancer cells has not been fully elucidated.
Ji Hun Jang, Dong Jun Kim, Soo-Youn Ham, Mai-Tram Vo, So Yeon Jeong, Seong Hee Choi, Seong Soon Park, Do Yong Jeon, Byung Ju Lee, Byung Kyun Ko, Wha Ja Cho, Jeong Woo Park   +11 more
openaire   +2 more sources

Effect of tristetraprolin on esophageal squamous cell carcinoma cell proliferation.

Tissue & Cell
BACKGROUND Tristetraprolin (TTP) can inhibit the abnormal proliferation of malignant tumors but there are no studies involving TTP and esophageal squamous cell carcinoma (ESCC).
Xiaoya Deng, Xiaoqin Luo, Zhanglan Fang, Xinyu Chen, Qinli Luo   +4 more
semanticscholar   +1 more source

Direct association of tristetraprolin with the nucleoporin CAN/Nup214

Biochemical and Biophysical Research Communications, 2004
Tristetraprolin (TTP) is a widely expressed, zinc finger-containing protein that has been implicated in the regulation of TNFalpha production in mice. Stimulus-dependent cytoplasmic translocation of TTP has been demonstrated in several cells. In this report we used the yeast two-hybrid screen to identify proteins able to interact with full length ...
Julie Carman, Steven G Nadler
exaly   +3 more sources

Tristetraproline in breast cancer: treat or trick?

2022
Abstract Breast cancer is one of the most common types of cancer. It is very heterogeneous, hence still complicated to diagnose despite of decades of research. Post-transcriptional regulation of gene expression is crucial for modulation of cell networking and is performed via different regulatory molecules. Tristetraproline (TTP) is RNA-
Kropyvko Serhii, Hubiernatorova Anastasiia, Mankovska Oksana, Syvak Liubov, Verovkina Nataliia, Lyalkin Sergii, Lavrynenko Kyrylo, Ivasechko Iryna, Stoika Rostyslav, Rynditch Alla   +9 more
openaire   +1 more source

Resveratrol ameliorates LPS-induced acute lung injury mouse model via induction of Tristetraprolin.

Combinatorial chemistry & high throughput screening, 2022
AIM In this study, we aimed to investigate whether resveratrol has anti-inflammatory effects on LPS-induced ALI via TTP enhancement. BACKGROUND Acute lung injury (ALI) is a syndrome of diffuse infammatory lung injury with increased pulmonary edema and ...
Yonghong Zhang, Guizuo Wang, Dexin Zhang, Xiu-zhen Sun   +3 more
semanticscholar   +1 more source

Tristetraprolin and Its Role in Regulation of Airway Inflammation

Molecular Pharmacology, 2015
Chronic inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are clinically and socioeconomically important diseases globally. Currently the mainstay of anti-inflammatory therapy in respiratory diseases is corticosteroids.
Pavan, Prabhala, Alaina J, Ammit
openaire   +2 more sources