Results 171 to 180 of about 3,877 (200)

The Cross-talk between Tristetraprolin and Cytokines in Cancer

Anti-Cancer Agents in Medicinal Chemistry, 2017
Cytokines are small secreted proteins serving as vital mediators that mediate the host immune responses. Transcription and post-transcription play a critical role in cytokine expression through the regulation of message RNA (mRNA) cytoplasmic localization, translation initiation and decay.
Jian, Guo, Hao, Wang, Shiyi, Jiang, Jiazeng, Xia, Shimao, Jin   +4 more
openaire   +2 more sources

LncRNA AA465934 Improves Podocyte Injury by Promoting Tristetraprolin-Mediated HMGB1 DownRegulation in Diabetic Nephropathy

Molecular and Cellular Biology
Although LncRNA AA465934 expression is reduced in high glucose (HG)-treated podocytes, its role in HG-mediated podocyte injury and diabetic nephropathy (DN) remains unknown.
Nan Yang, Yue Zhang, Peiyao Ren, Li Zhao, Danna Zheng, Lanjun Fu, Juan Jin   +6 more
semanticscholar   +1 more source

Gene suppression by tristetraprolin and release by the p38 pathway

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001
Tristetraprolin (TTP) is a zinc finger protein that has been implicated in the control of tumor necrosis factor (TNF) mRNA stability. We show here that TTP protein has a suppressive effect on promoter elements from TNF-α and interleukin-8 and that lipopolysaccharide (LPS) stimulation can release this suppression. The release in LPS-stimulated cells was
Zhu, W., Brauchle, M. A., Di Padova, F., Gram, H., New, L., Ono, K., Downey, J. S., Han, J. H.   +7 more
openaire   +2 more sources

Inhibition of tristetraprolin expression by dexamethasone in activated macrophages

Biochemical Pharmacology, 2005
Tristetraprolin (TTP) is a factor that regulates mRNA stability and the expression of certain inflammatory genes. In the present study, we found that TTP expression was increased in macrophages exposed to bacterial lipopolysaccharide (LPS). Dexamethasone and dissociated steroid RU24858 inhibited LPS-induced TTP protein and mRNA expression and the ...
Ulla, Jalonen, Aleksi, Lahti, Riku, Korhonen, Hannu, Kankaanranta, Eeva, Moilanen   +4 more
openaire   +2 more sources

The RNA Binding Protein Tristetraprolin Contributes to CFTR mRNA Stability in Cystic Fibrosis.

American Journal of Respiratory Cell and Molecular Biology
Cystic Fibrosis (CF) is the most common inherited disorder and is characterized by an inflammatory phenotype. Here, we found that in bronchial epithelium reconstituted form lung tissue biopsies from patients with CF, the RNA-binding protein ...
A. Pommier, Solenne Bleuse, Karine Delétang, Jessica Varilh, M. Nadaud, P. Boisguérin, Arnaud Bourdin, M. Taulan-Cadars   +7 more
semanticscholar   +1 more source

Abstract 5634: Tristetraprolin induces an antitumorigenic phenotype in triple negative breast cancer via a novel non-canonical mechanism

Cancer Research
The ultimate cause of death for most triple negative breast cancer (TNBC) patients is metastatic disease, which has a five-year survival rate of 12.8%.
Julia L. Rutherford, Megan B Stemberger, Rohaan Mahmud, Christina R. Ross, E. J. White, G. M. Wilson   +5 more
semanticscholar   +1 more source

Molecular identification of the gene encoding porcine tristetraprolin (TTP)

Molecular and Cellular Biochemistry, 2010
Tristetraprolin (TTP) is a CCCH tandem zinc finger protein that can bind to and destabilize certain mRNAs containing AU-rich element (ARE) binding sites. In this study, a novel porcine cDNA has been isolated by expressed sequence tag assembly and subsequently confirmed by RT-PCR analysis, and designated porcine TTP (poTTP).
Zheng-Bing, Guan, Yan, Shui, Jian, Lu
openaire   +2 more sources

Analysis of the function, expression, and subcellular distribution of human tristetraprolin

Arthritis & Rheumatism, 2002
AbstractObjectiveThe zinc‐finger protein tristetraprolin (TTP) has been demonstrated to regulate tumor necrosis factor α (TNFα) messenger RNA (mRNA) instability in murine macrophages. We sought to develop a model system to characterize the effects of human TTP (hTTP) on TNFα 3′‐untranslated region (3′‐UTR)‐mediated expression.
Seth A, Brooks, John E, Connolly, Roger J, Diegel, Roy A, Fava, William F C, Rigby   +4 more
openaire   +2 more sources

Tristetraprolin (ZFP36) and TIS11B (ZFP36-L1)

2016
International ...
Cherradi, Nadia, Feige, Jean-Jacques
openaire   +3 more sources

The role of tristetraprolin in inflammation and disease

2010
Uncovering control of gene expression by transcriptional and posttranscriptional mechanisms is of uppermost importance for the understanding of human pathologies. While the transcriptional level has been extensively studied in the past, in recent years more and more studies focus on the control of RNA maturation, transport, stability and translation ...
openaire   +1 more source