Results 41 to 50 of about 116,083 (186)

Toward in vivo proof of binding of 18F-labeled inhibitor [18F]TRACK to peripheral tropomyosin receptor kinases

EJNMMI Research, 2022
Background Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are a family of tyrosine kinases primarily expressed in neuronal cells of the brain. Identification of oncogenic alterations in Trk expression as a driver in multiple tumor types has increased ...
Melinda Wuest, Justin J. Bailey, Jennifer Dufour, Darryl Glubrecht, Vanessa Omana, Tom H. Johnston, Jonathan M. Brotchie, Ralf Schirrmacher   +7 more
doaj   +1 more source

New, potent, small molecule agonists of tyrosine kinase receptors attenuate dry eye disease

Frontiers in Medicine, 2022
Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin3 (NT-3) bind to tyrosine kinase (Trk) receptors, TrkA, TrkB, and TrkC, respectively. This study investigated the efficacy of novel molecule agonists of Trk receptors in
Zhiyuan Yu, Shaon Joy, Tianxiong Mi, Ghasem Yazdanpanah, Kevin Burgess, Cintia S. de Paiva   +5 more
doaj   +1 more source

Two-dimensional effective action for matter fields coupled to the dilaton [PDF]

, 1999
We revise the calculation of the one-loop effective action for scalar and spinor fields coupled to the dilaton in two dimensions. Applying the method of covariant perturbation theory for the heat kernel we derive the effective action in an explicitly ...
A. G. Mirzabekian, A. I. Zelnikov, A. M. Polyakov, A. O. Barvinsky, A. O. Barvinsky, A. O. Barvinsky, A. O. Barvinsky, A. O. Barvinsky, A. O. Barvinsky, A. O. Barvinsky, B. S. DeWitt, C. G. Callan, E. S. Fradkin, E. S. Fradkin, F. C. Lombardo, H. Balasin, J. Erdmenger, J. G. Russo, J. S. Dowker, J. S. Dowker, J. S. Dowker, P. Haberl, R. Balbinot, R. Balbinot, R. Balbinot, R. Bousso, S. F. Wilk, S. Nojiri, S. Nojiri, S. Nojiri, T. Chiba, V. Mukhanov, V. P. Frolov, W. Kummer, W. Kummer, W. Kummer, Yu. V. Gusev, Yu. V. Gusev, Yu. V. Gusev   +38 more
core   +2 more sources

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Changes in Plasma TPH2, GDNF, Trk-b, BDNF, and proBDNF in People Who Died by Suicide

Brain Sciences, 2023
Recent studies have shown that neuropeptides and neurotrophic factors may be involved in the pathophysiological mechanisms of suicide. However, the current research on this aspect is still insufficient.
Xiaoyu Liu, Shangda Li, Yueran Yu, Jianbo Hu, Yi Xu   +4 more
doaj   +1 more source

Larotrectinib efficacy and safety in TRK fusion cancer: An expanded clinical dataset showing consistency in an age and tumor agnostic approach [PDF]

, 2018
Background: TRK fusion cancer results from gene fusions involving NTRK1, NTRK2 or NTRK3. Larotrectinib, the first selective TRK inhibitor, has demonstrated an overall response rate (ORR) of 75% with a favorable safety profile in the first 55 ...
Albert, C. M., Berlin, J. D., Bielack, S. S., Cox, M. C., Cruickshank, S., Doz, F., Drilon, A., Dubois, S. G., Federman, N., Geoerger, B., Hong, D. S., Ku, N. C., Kummar, S., Lassen, U. N., Mascarenhas, L., McDermott, R., Oh, D. Y., Schilder, R. J., Tan, D. S., van Tilburg, C. M.   +19 more
core   +1 more source

N=2 Instanton Effective Action in Omega-background and D3/D(-1)-brane System in R-R Background

, 2011
We study the relation between the ADHM construction of instantons in the Omega-background and the fractional D3/D(-1)-branes at the orbifold singularity of C \times C^2/Z_2 in Ramond-Ramond (R-R) 3-form field strength background.
A Iqbal, A Iqbal, C-S Chu, D Friedan, E Corrigan, E Witten, E Witten, F Fucito, GW Moore, H Awata, H Osborn, Hiroaki Nakajima, I Antoniadis, I Antoniadis, J Boer de, J Polchinski, K Ito, K Ito, K Ito, K Ito, Katsushi Ito, LJ Dixon, LJ Dixon, M Bershadsky, M Billò, M Billò, M Billò, M Billò, M Billò, M Taki, MF Atiyah, N Berkovits, N Dorey, N Dorey, N Nekrasov, N Nekrasov, N Seiberg, NA Nekrasov, S Hamidi, Shin Sasaki, T Eguchi, Takuya Saka, U Bruzzo, VA Kostelecky   +43 more
core   +1 more source

Performance Improvements for the ATLAS Detector Simulation Framework [PDF]

, 2013
Many physics and performance studies carried out with the ATLAS detector at the Long Hadron Collider (LHC) require very large event samples. A detailed simulation for the detector, however, requires a great amount of CPU resources.
Almalioglu Yasin, Ritsch Elmar, Salzburger Andreas   +2 more
core   +1 more source

Immunohistochemistry and next-generation sequencing for NTRK fusion detection in differentiated thyroid cancer of children, adolescents and young adults

Brazilian Journal of Oncology
Introduction: Pan-TRK immunohistochemistry staining can assess the protein expression from NTRK gene fusions. A little is known about its utility in differentiated thyroid cancer samples from children, adolescents, and young adults patients.
Ana Clara Oliveira Tosta Telles, Gabriel Jeferson Rodríguez Machado, Juliana Lima von-Ammon, Rafael Reis Campos da-Matta, Taíse Lima Cerqueira de-Oliveira, Fabyan Esberard de Lima Beltrão, Alexandre Rolim da-Paz, Fabio Hecht, Guilherme de Castro Lopes, Leonardo Freitas Boaventura Rios, Bruno da Silva Lisboa, Helton Estrela Ramos   +11 more
doaj   +1 more source

Generalizing Lieb's Concavity Theorem via Operator Interpolation [PDF]

, 2020
We introduce the notion of $k$-trace and use interpolation of operators to prove the joint concavity of the function $(A,B)\mapsto\text{Tr}_k\big[(B^\frac{qs}{2}K^*A^{ps}KB^\frac{qs}{2})^{\frac{1}{s}}\big]^\frac{1}{k}$, which generalizes Lieb's concavity
Huang, De
core   +1 more source