Results 121 to 130 of about 34,874 (291)

NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish

Scientific Reports, 2017
Expression of neuroendocrine-associated phosphatase (NEAP, also named as dual specificity phosphatase 26, [DUSP26]) is restricted to neuroendocrine tissues. We found that NEAP, but not its phosphatase-defective mutant, suppressed nerve growth factor (NGF)
Chi-Hwa Yang, Yu-Jung Yeh, Jiz-Yuh Wang, Ya-Wen Liu, Yen-Lin Chen, Hui-Wen Cheng, Chun-Mei Cheng, Yung-Jen Chuang, Chiou-Hwa Yuh, Yi-Rong Chen   +9 more
doaj   +1 more source

Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells [PDF]

, 2013
Background: TrkA is a transmembrane receptor tyrosine kinase for nerve growth factor. Results: TrkA forms a molecular complex with insulin receptor and IRS-1 to induce Akt and Erk5 phosphorylation.
Babu, Jeganathan Ramesh, Geetha, Thangiah, Mathews, Salome E., Meakin, Susan O., Rege, Shraddha D., White, Morris F.   +5 more
core   +2 more sources

Nerve growth factor precursor alterations in neuron‐derived extracellular vesicles from individuals with Down syndrome along the Alzheimer's disease continuum

Alzheimer's &Dementia, Volume 21, Issue 4, April 2025.
Abstract BACKGROUND In Down syndrome (DS) and Alzheimer's disease (AD), nerve growth factor precursor protein (proNGF) accumulates in the brain. However, its non‐invasive detection using neuron‐derived extracellular vesicles (NDEVs) from plasma remains unexplored. METHODS We included 139 adults with DS (45 asymptomatic [aDS], 94 symptomatic for AD [sDS]
Natalia Valle‐Tamayo, Mateus Rozalem Aranha, Rocío Pérez‐González, Sara Serrano‐Requena, Laura Videla, Isabel Barroeta, Bessy Benejam, Gemma Chiva‐Blanch, Amanda Jimenez, Jorge Busciglio, Thomas Wisniewski, Sonia Do Carmo, Esther Álvarez‐Sánchez, Laia Muñoz, Alexandre Bejanin, Olivia Belbin, Daniel Alcolea, María Carmona‐Iragui, Alberto Lleó, A. Claudio Cuello, Juan Fortea, Oriol Dols‐Icardo, M. Florencia Iulita   +22 more
wiley   +1 more source

On the Shape of Things: From holography to elastica [PDF]

, 2017
We explore the question of which shape a manifold is compelled to take when immersed in another one, provided it must be the extremum of some functional.
Fonda, Piermarco, Jejjala, Vishnu, Veliz-Osorio, Alvaro   +2 more
core   +3 more sources

Escherichia coli in the production of biopharmaceuticals

Biotechnology and Applied Biochemistry, Volume 72, Issue 2, Page 528-541, April 2025.
Abstract Escherichia coli has shouldered a massive workload with the discovery of recombinant DNA technology. A new era began in the biopharmaceutical industry with the production of insulin, the first recombinant protein, in E. coli and its use in treating diabetes. After insulin, many biopharmaceuticals produced from E. coli have been approved by the
İbrahim İncir, Özlem Kaplan
wiley   +1 more source

Loss of NGF-TrkA signaling from the CNS is not sufficient to induce cognitive impairments in young adult or intermediate-aged mice [PDF]

, 2012
Many molecules expressed in the CNS contribute to cognitive functions either by modulating neuronal activity or by mediating neuronal trophic support and/or connectivity. An ongoing discussion is whether signaling of nerve growth factor (NGF) through its
Besusso, Dario, Cestari, Vincenzo, Costanzi, Marco, Geibel, Mirjam, Horn, Jacqueline M, Koudelka, Juraj, Minichiello, Liliana, Müller, Markus, Triaca, Viviana   +8 more
core   +1 more source

The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology

International Journal of Molecular Sciences, 2017
Dysfunction of nerve growth factor (NGF) and its high-affinity Tropomyosin receptor kinase A (TrkA) receptor has been suggested to contribute to the selective degeneration of basal forebrain cholinergic neurons (BFCN) associated with the progressive ...
N. Canu, G. Amadoro, V. Triaca, V. Latina, V. Sposato, V. Corsetti, C. Severini, M. Ciotti, P. Calissano   +8 more
semanticscholar   +1 more source

Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling

Communications Biology, 2020
Using genetic code expansion, Zhao, Shi et al. generate light-sensitive tyrosine analogues to obtain insights into the activation of the NGF receptor, TrkA.
Shu Zhao, Jia Shi, Guohua Yu, Dali Li, Meng Wang, Chonggang Yuan, Huihui Zhou, Amirabbas Parizadeh, Zhenlin Li, Min-Xin Guan, Shixin Ye   +10 more
doaj   +1 more source

Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis

Arthritis Research & Therapy, 2016
BackgroundInflammation is an essential component of arthritis pain. Nerve growth factor (NGF) plays a key role in acute and chronic pain states especially those associated with inflammation. NGF acts through tropomyosin-receptor-kinase A (TrkA).
S. Ashraf, K. Bouhana, J. Pheneger, S. Andrews, D. Walsh   +4 more
semanticscholar   +1 more source

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Amelie Gormand, B Schoeberl, BN Kholodenko, BR Voldborg, C Dong, CJ Wikstrand, CY Huang, David R Gilbert, DK Moscatello, E Douville, FA Brightman, GEP Box, H Davies, HS Huang, J Pinney, JE Ferrell Jr, JL Bos, JS Oliveira, KS Brown, L Gao, M Calder, M Hucka, MH Schmidt, Michiel E Adriaens, N Chabrier, Oliver E Sturm, PA Humphrey, PA Humphrey, RD York, Richard J Orton, RJ Orton, RJ Orton, S Corbalan-Garcia, S Hoops, S Kao, S Sasagawa, S Traverse, S Traverse, S Yoon, SB Waters, SD Santos, SH Bigner, TA Libermann, V De Falco, Walter Kolch, WJ Langlois, WR Burack, YH Xu, YR Chen   +48 more
core   +3 more sources