Results 31 to 40 of about 34,874 (291)
TrkA inhibition alleviates bladder overactivity in cyclophosphamide-induced cystitis by targeting hyperpolarization-activated cyclic nucleotide-gated channels [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): To investigate the potential of Tropomyosin receptor kinase A (TrkA) for the treatment of interstitial cystitis/ bladder pain syndrome (IC/BPS).Materials and Methods: Sixty-four female rats were randomly assigned to the control and ...
Qian Liu +4 more
doaj +1 more source
Science Advances, 2020 Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease. The degeneration of cholinergic neurons is a prominent feature of Alzheimer’s disease (AD). In animal models of injury and aging,
Kristiana Xhima +6 more
semanticscholar +1 more source
Oncogenesis, 2022 Neuroblastoma (NB) is a childhood tumor derived from the sympathoadrenal lineage of the neural crest progenitor cells. Core 1 β1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation, and its altered expression ...
Neng-Yu Lin +11 more
doaj +1 more source
Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice [PDF]
The Journal of Neuroscience, 1995 Experiments over the past decade in which NGF/TrkA signaling has been abolished by antibodies or targeted gene mutations have shown that 70- 85% of dorsal root ganglion (DRG) neurons require NGF for survival during development. There is consensus that many of the NGF-dependent neurons are small-diameter, peptidergic neurons subserving nociception ...
Inmaculada Silos-Santiago +6 more
openaire +3 more sources
Physical mapping of the K+ transport trkA gene of Escherichia coli and overproduction of the TrkA protein [PDF]
Journal of Bacteriology, 1987 The position on the Escherichia coli chromosome of trkA, a gene coding for a membrane protein involved in K+ transport by the constitutive uptake system Trk, was determined. We observed that the gene is transcribed in a clockwise direction and that it is located at 72.4 min on the chromosome in a 1.75-kilobase NruI-EcoRV DNA fragment 1.0 kilobase ...
D Bossemeyer, A Hamann, Evert P. Bakker
openaire +3 more sources
Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
Scientific Reports, 2023 Proper wiring of the peripheral nervous system relies on neurotrophic signaling via nerve growth factor (NGF). NGF secreted by target organs (i.e. eye) binds to the TrkA receptor expressed on the distal axons of postganglionic neurons. Upon binding, TrkA
Ashley J. Mason +4 more
doaj +1 more source
Zhongliu Fangzhi Yanjiu, 2018 Objective To evaluate the potential association of nerve growth factor (NGF) and its receptors TrkA and p75NRT with perineural invasion(PNI) and other clinicopathological features of early-stage cervical cancer.
LONG Ying +5 more
doaj +1 more source
Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]
, 2006 Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Berry, Carol +6 more
core +1 more source
Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles [PDF]
, 2020 Extraocular muscles (EOMs) show resistance to muscle dystrophies and sarcopenia. It has been recently demonstrated that they are endowed with different types of myogenic cells, all of which present an outstanding regenerative potential. Neurotrophins are
Benítez Temiño, Beatriz +3 more
core +1 more source
Journal of Neuroinflammation, 2020 Nerve growth factor (NGF) and its receptors, tropomyosin receptor kinase A (TrkA) and pan-neurotrophin receptor p75 (p75NTR), are known to play bidirectional roles between the immune and nervous system.
Nickoleta Delivanoglou +10 more
semanticscholar +1 more source