Results 41 to 50 of about 34,874 (291)
TrkA activation in the rat visual cortex by antirat trkA IgG prevents the effect of monocular deprivation [PDF]
European Journal of Neuroscience, 1999 AbstractIt has been recently shown that intraventricular injections of nerve growth factor (NGF) prevent the effects of monocular deprivation in the rat. We have tested the localization and the molecular nature of the NGF receptor(s) responsible for this effect by activating cortical trkA receptors in monocularly deprived rats by cortical infusion of a
PIZZORUSSO, TOMMASO +6 more
openaire +5 more sources
TrkA Bumps into Its Future Self [PDF]
Developmental Cell, 2017 In neurons, correct targeting of receptors to the axon is critical for cell survival and circuit formation. In this issue of Developmental Cell, Yamashita et al. (2017) report that the ER-resident phosphatase PTP1B is required to prime TrkA for axonal transport.
Bettina Winckler +3 more
openaire +3 more sources
Fracture repair requires TrkA signaling by skeletal sensory nerves.
Journal of Clinical Investigation, 2019 Bone is richly innervated by nerve growth factor-responsive (NGF-responsive) tropomyosin receptor kinase A-expressing (TrKa-expressing) sensory nerve fibers, which are required for osteochondral progenitor expansion during mammalian skeletal development.
Zhu Li +8 more
semanticscholar +1 more source
Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]
, 2011 Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell +39 more
core +2 more sources
NGF, TrkA-P and neuroprotection after a hypoxic event in the developing central nervous system [PDF]
, 2018 A decrease in the concentration of oxygen in the blood and tissues (hypoxia) produces important, sometimes irreversible, damages in the central nervous system (CNS) both during development and also postnatally.
Bogetti, María Eugenia +4 more
core +1 more source
Pain, 2020 Mechanical allodynia is a cardinal sign of several inflammatory pain disorders where Nerve Growth Factor, a prototypic neurotrophin, plays a crucial role by binding to TrkA receptors.
Tanguy Chaumette +13 more
semanticscholar +1 more source
Alternative TrkA Splicing and Neuroblastoma [PDF]
, 2012 Neuroblastoma is one of the most frequent solid paediatric tumours of the nervous system, accounting for up to 10% of all paediatric tumours. The majority of NBs originate from a sympathoadrenal cell lineage of neural crest origin during sympathetic nervous system development, and represent a heterogeneous group of tumours that exhibit a high degree of
FARINA, ANTONIETTA +7 more
openaire +4 more sources
TrkA Signalling and Parkinson’s Dementia
, 2022 Cognitive impairment and dementia are the most frequently occurring nonmotor symptoms in Parkinson’s disease (PD), yet these symptoms are mostly overlooked and are not diagnosed and treated exceptionally like the cardinal motor symptoms in clinical practice.
Justin Antony, J. Jeyaram Bharathi
openaire +4 more sources
Cells, 2022 The Nerve Growth Factor (NGF) belongs to the neurothrophins protein family involved in the survival of neurons in the nervous system. The interaction of NGF with its high-affinity receptor TrkA mediates different cellular pathways related to Alzheimer’s ...
Serena Vittorio +6 more
doaj +1 more source
Expression of Neurotrophins and Their Receptors Tropomyosin-related kinases (Trk) under Tension-stress during Distraction Osteogenesis [PDF]
, 2006 The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation.
Aiga, Ayako +6 more
core +1 more source