Results 61 to 70 of about 35,994 (298)

ProNGF and Neurodegeneration in Alzheimer’s Disease

Frontiers in Neuroscience, 2019
Profound and early basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Alzheimer’s disease (AD). Loss of synapses between basal forebrain and hippocampal and cortical target tissue correlates highly with the degree of dementia and is ...
Margaret Fahnestock, Arman Shekari
doaj   +1 more source

Deletion of Tsc2 in nociceptors reduces target innervation, ion channel expression, and sensitivity to heat [PDF]

, 2018
The mechanistic target of rapamycin complex 1 (mTORC1) is known to regulate cellular growth pathways, and its genetic activation is sufficient to enhance regenerative axon growth following injury to the central or peripheral nervous systems.
Carlin, Dan, Cavalli, Valeria, Gereau, Robert W, Golden, Judith P, Mogha, Amit, Monk, Kelly R, Samineni, Vijay K   +6 more
core   +2 more sources

Characterization of TRKA signaling in acute myeloid leukemia [PDF]

Oncotarget, 2018
Tropomyosin-related kinase A (TRKA) translocations have oncogenic potential and have been found in rare cases of solid tumors. Accumulating evidence indicates that TRKA and its ligand, nerve growth factor (NGF), may play a role in normal hematopoiesis and may be deregulated in leukemogenesis. Here, we report a comprehensive evaluation of TRKA signaling
Shelley M. Herbrich, Patrick A. Zweidler-McKay, Riitta Nolo, Joya Chandra, Marisa J Hornbaker, Sankaranarayanan Kannan   +5 more
openaire   +3 more sources

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors.

Journal of Medicinal Chemistry, 2019
Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are activated by hormones of the neurotrophin family: nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4).
S. Bagal, Kiyoyuki Omoto, D. Blakemore, P. Bungay, J. Bilsland, Philip J Clarke, M. Corbett, C. Cronin, Jingrong Jean Cui, R. Dias, Neil J Flanagan, S. Greasley, R. Grimley, Eric Johnson, D. Fengas, Linda Kitching, M. Kraus, Indrawan J. McAlpine, Asako Nagata, Gareth J Waldron, J. Warmus   +20 more
semanticscholar   +1 more source

Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]

, 2017
The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo, Altissimi, Giancarlo, Artico, Marco, Bardella, Lia, Giangaspero, Felice, Minni, Antonio, Parnigotto, Pier Paolo, Pastore, Francesco Saverio, Spoletini, Marialuisa, Taurone, Samanta, Tombolini, Mario, Wierzbicki, Venceslao   +11 more
core   +1 more source

Effects of castration on the expression of the NGF and TrkA in the vas deferens and accessory male genital glands of the rat

European Journal of Histochemistry, 2009
Nerve Growth Factor (NGF) is a member of the neurotrophin family. Neurotrophins exert their effects by binding to corresponding receptors, which are formed by the tyrosine protein kinases TrkA, TrkB, and TrkC, and the low affinity p75NTR receptor.
C. Squillacioti, A. De Luca, S. Paino, E. Langella, N. Mirabella   +4 more
doaj   +3 more sources

Retrogradely Transported TrkA Endosomes Signal Locally within Dendrites to Maintain Sympathetic Neuron Synapses

Cell Reports, 2017
Sympathetic neurons require NGF from their target fields for survival, axonal target innervation, dendritic growth and formation, and maintenance of synaptic inputs from preganglionic neurons.
Kathryn M. Lehigh, Katherine M. West, David D. Ginty   +2 more
doaj   +1 more source

Huntingtin-associated protein 1 ameliorates neurological function rehabilitation by facilitating neurite elongation through TrKA-MAPK pathway in mice spinal cord injury

Frontiers in Molecular Neuroscience, 2023
AimsHuntingtin-associated protein 1 (HAP1) is a neuronal protein closely associated with microtubules and might facilitate neurological function rehabilitation.
Li Miao, Li Miao, Li Miao, Sun Wan Qing, Lu Tao   +4 more
doaj   +1 more source

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.

PLoS ONE, 2019
In the brain, the TrkA receptor for Nerve Growth Factor (NGF) is expressed primarily in the cholinergic system. TrkA/NGF support neuronal health and function, and deficiencies in this axis are associated with progressive cholinergic neuron atrophy and ...
Sylvia Josephy-Hernandez, Iulia Pirvulescu, Mario Maira, Tahar Aboulkassim, Tak Pan Wong, R Anne McKinney, H Uri Saragovi   +6 more
doaj   +1 more source

Non-Aβ-dependent factors associated with global cognitive and physical function in alzheimer's disease: a pilot multivariate analysis [PDF]

, 2019
Recent literature highlights the importance of identifying factors associated with mild cognitive impairment (MCI) and Alzheimer's Disease (AD).
Di Baldassarre, Angela, Fonte, Cristina, Galazzo, Ilaria Boscolo, Ghinassi, Barbara, Muti, Ettore, Naro, Fabio, Pedrinolla, Anna, Pizzini, Francesca Benedetta, Rende, Mario, Schena, Federico, Smania, Nicola, Stabile, Anna Maria, Tamburin, Stefano, Venneri, Mary Anna, Venturelli, Massimo   +14 more
core   +2 more sources