Results 71 to 80 of about 36,447 (274)

Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]

, 2007
The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
AlQatari, M, Ernfors, P, Hjerling-Leffler, J, Koltzenburg, M   +3 more
core   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, Volume 16, Issue 2, Page 252-267, February 2026.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Nogo-p4 Suppresses TrkA Signaling Induced by Low Concentrations of Nerve Growth Factor Through NgR1 in Differentiated PC12 Cells

Neurosignals, 2016
Background: Regeneration of injured axons in adult mammalian central nervous system (CNS) is not spontaneous. Nogo is a major inhibitory molecule contributing to axon regeneration failure.
You-Ming Fan, Qing-Yuan Huang, Yin-Ai Wu, Alan R. Harvey, Qi Cui, Yu-Qi Gao   +5 more
doaj   +1 more source

Perspectives on the Trypanosoma cruzi-host cell receptor interaction [PDF]

, 2009
Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions.
A Belley, A Buschiazzo, AC Frasch, AC Monteiro, AC Monteiro, AG Todorov, AJS Augustine, AK Vaidian, AL Leal, AM Celentano, AM Silber, AM Woolsey, Anthony W. Ashton, AP Lima, AW Ashton, AW Ashton, BA Burleigh, BA Burleigh, BA Burleigh, BK Kubata, C Claser, CA Buscaglia, CA Petersen, CW Turner, E Del Nery, E Ortega-Barria, F Leeb-Lundberg, F Marceau, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, Fabiana S. Machado, Fangxia Guan, Fernando Villalta, GS Hassan, HB Tanowitz, HB Tanowitz, HB Tanowitz, HB Tanowitz, Herbert B. Tanowitz, Huan Huang, IC Cuevas, IM Bastos, J Aliberti, J Scharfstein, J Scharfstein, JC Engel, JL Croxford, JM Di Noia, Julio Scharfstein, K Kabashima, KD Bhoola, Kevin M. Tyler, KJ Simmons, KM Tyler, L Sterin-Borda, LO Andrade, Louis M. Weiss, LX Liu, M de Melo-Jorge, M Einicker-Lamas, M Ming, MA Campos, MA Ouaissi, Maria F. Lima, MC Taylor, ME McGrath, MF Lima, MF Lima, MH Magdesian, MJ Alves, MN Meirelles, MV Chuenkova, MV Chuenkova, MV Chuenkova, MV Chuenkova, N Garg, N Garg, N Yoshida, P Grellier, PJ Pereira, PN Nde, R Agusti, R Giordano, R Manning-Cela, RA Skidgel, RL Cardoni, S Favoreto Jr, S Mukherjee, S Mukherjee, S Mukherjee, S Schenkman, S Vaena de Avalos, Sandra Alvarez, SB Petkova, SB Petkova, SG Andrade, Shankar Mukherjee, SM Factor, T Moody, VL Hideko Tatakihara, YY Kleshchenko   +108 more
core   +1 more source

Physical mapping of the K+ transport trkA gene of Escherichia coli and overproduction of the TrkA protein [PDF]

Journal of Bacteriology, 1987
The position on the Escherichia coli chromosome of trkA, a gene coding for a membrane protein involved in K+ transport by the constitutive uptake system Trk, was determined. We observed that the gene is transcribed in a clockwise direction and that it is located at 72.4 min on the chromosome in a 1.75-kilobase NruI-EcoRV DNA fragment 1.0 kilobase ...
A, Hamann, D, Bossemeyer, E P, Bakker
openaire   +2 more sources

Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane.

PLoS ONE, 2015
Clostridium perfringens alpha-toxin elicits various immune responses such as the release of cytokines, chemokines, and superoxide via the GM1a/TrkA complex.
Teruhisa Takagishi, Masataka Oda, Michiko Kabura, Mie Kurosawa, Kaori Tominaga, Shiori Urano, Yoshibumi Ueda, Keiko Kobayashi, Toshihide Kobayashi, Jun Sakurai, Yutaka Terao, Masahiro Nagahama   +11 more
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Nerve growth factor and Tropomyosin receptor kinase A are increased in the gastric mucosa of patients with functional dyspepsia

BMC Gastroenterology, 2019
Background Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD).
Haitao Shi, Shanshan Zhu, Bin Qin, Lianli Wang, Juan Yang, Guolong Lu, Fei Dai   +6 more
doaj   +1 more source

Association of NGF receptors with membrane rafts in PC12 cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 2001
Nerve Growth Factor (NGF) signal transduction is involved in the survival, differentiation and maintenance of neurons through the receptors TrkA and p75NTR. These receptors activate downstream protein kinase cascades that regulate cell survival.
Clements, Shona Marie
core  

The effect of vascular graft and human umbilical cord blood-derived CD34+ stem cell on peripheral nerve healing [PDF]

, 2018
AIM: There are many trials concerning peripheral nerve damage causes and treatment options. Unfortunately, nerve damage is still a major problem regarding health, social and economic issues.
Abban, G., Coskun, E., Erdoğan, Çağdaş, Ozkul, A., Sahin, B., Topcu, A., Yilmaz, A.   +6 more
core   +1 more source