Results 71 to 80 of about 34,874 (291)
Protein & Cell, 2018 Sympathetic arborizations act as the essential efferent signals in regulating the metabolism of peripheral organs including white adipose tissues (WAT).
Ying Cao, Huanhuan Wang, W. Zeng
semanticscholar +1 more source
TRAF4‐mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis
Journal of Clinical Investigation, 2018 &NA; Receptor tyrosine kinases (RTKs) are important drivers of cancers. In addition to genomic alterations, aberrant activation of WT RTKs plays an important role in driving cancer progression.
Ramesh Singh +9 more
semanticscholar +1 more source
Molecular and Cellular Neuroscience, 2005 NGF binds to two receptors, p75NTR and TrkA. The endosomal trafficking of receptors is of emerging importance for the understanding of their signaling. We compared the endocytic trafficking of the two NGF receptors in PC12 cells. Both p75NTR and TrkA were internalized in response to NGF and colocalized with early endosomes.
Charles L. Howe +7 more
openaire +4 more sources
Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements [PDF]
, 2001 Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown.
Asavaritikrai, P +3 more
core +1 more source
Disentangling the signaling complexity of nerve growth factor receptors by CRISPR/Cas9 [PDF]
, 2022 The binding of nerve growth factor (NGF) to the tropomyosin-related kinase A (TrkA) and p75(NTR) receptors activates a large variety of pathways regulating critical processes as diverse as proliferation, differentiation, membrane potential, synaptic ...
Cattaneo, Antonino +5 more
core +1 more source
Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis
Arthritis &Rheumatology, EarlyView.Objective Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune‐regulatory cells in pain is unknown. Our objective was to identify synovial innate immune
Holly T. Philpott +14 more
wiley +1 more source
Frontiers in Oncology, 2019 Pediatric cancers represent a wide variety of different tumors, though they have unique features that distinguish them from adult cancers. Receptor tyrosine kinases KIT and TrkA functions in AML and NB, respectively, are well-characterized.
T. Lebedev +5 more
semanticscholar +1 more source
NGF – the TrkA to successful pain treatment
Journal of Pain Research, 2012 Chronic pain arising from various pathological conditions such as osteoarthritis, low back or spinal injuries, cancer, and urological chronic pelvic pain syndromes presents significant challenges in diagnosis and treatment. Specifically, since the underlying cause of these pain syndromes is unknown or heterogeneous, physicians diagnose and treat ...
Kumar, Vinayak, Mahal, Brandon
openaire +4 more sources
Novel mutations in UL24 and gH rescue efficient infection of an HSV vector retargeted to TrkA
Molecular Therapy: Methods & Clinical Development, 2023 Transductional targeting of herpes simplex virus (HSV)-based gene therapy vectors offers the potential for improved tissue-specific delivery and can be achieved by modification of the viral entry machinery to incorporate ligands that bind the desired ...
Marco Marzulli +5 more
doaj
BMC Neuroscience, 2020 Background Glucose fluctuation promotes neuronal apoptosis, which plays a central role in diabetic encephalopathy (DE). Nerve growth factor (NGF), and its interaction with high-affinity (TrkA) and low-affinity (p75NTR) receptors, are involved in neuronal
Ting Yan, Zhihui Zhang, Danqing Li
doaj +1 more source