Results 91 to 100 of about 4,753,527 (236)

Cortical Cholinergic Pathway Degeneration Reflects Cognitive Impairment and Dementia in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Cognitive impairment is a prevalent and debilitating feature of Parkinson's disease (PD). Increasing evidence from postmortem and in vivo positron emission tomography imaging studies supports cholinergic dysfunction in PD. There is, however, little evidence regarding the influence of the structural integrity of cortical cholinergic ...
Nicola M. Slater, Daniel J. Myall, Reza Shoorangiz, Wassilios G. Meissner, Ian J. Kirk, Ross J. Keenan, Rebecca M. Lee, Kyla‐Louise Horne, Michael R. MacAskill, Campbell J. Le Heron, Toni L. Pitcher, Tim J. Anderson, Tracy R. Melzer, John C. Dalrymple‐Alford   +13 more
wiley   +1 more source

Crystalline silica-induced recruitment and immuno-imbalance of CD4+ tissue resident memory T cells promote silicosis progression

Communications Biology
Occupational crystalline silica (CS) particle exposure leads to silicosis. The burden of CS-associated disease remains high, and treatment options are limited due to vague mechanisms.
Yichuan You, Xiulin Wu, Haoyang Yuan, Yangyang He, Yinghui Chen, Sisi Wang, Hui Min, Jie Chen, Chao Li   +8 more
doaj   +1 more source

Developmental plasticity allows outside-in immune responses by resident memory T cells

, 2020
Central memory T (TCM) cells patrol lymph nodes and perform conventional memory responses on restimulation: proliferation, migration and differentiation into diverse T cell subsets while also self-renewing. Resident memory T (TRM) cells are parked within
Raissa Fonseca, Fonseca, R, David Masopust, Scott, MC, Thompson, EA, Yiping Fan, Hazem E. Ghoneim, Milcah C. Scott, Lalit K. Beura, Wijeyesinghe, S, Vezys, V, Ghoneim, HE, Caitlin C. Zebley, Zebley, CC, Quarnstrom, CF, Emily A. Thompson, Fares-Frederickson, NJ, Borges da Silva, H, Clare F. Quarnstrom, Nancy J. Fares-Frederickson, Vaiva Vezys, Fan, Y, Sathi Wijeyesinghe, Masopust, D, Benjamin Youngblood, Youngblood, B, Henrique Borges da Silva, Beura, LK   +27 more
core   +1 more source

An integrated forest‐to‐market approach to promote lesser‐known timber species (LKTS) in a domestic timber market in the Congo Basin

PLANTS, PEOPLE, PLANET, EarlyView.
In the Congo Basin, domestic timber markets account for ~40% of timber consumption, yet demand is concentrated on a few high‐value species also sought after on international markets, raising concerns about their long‐term availability. We combine market, wood, and forest data to assess the potential of lesser‐known timber species (LKTS) to support a ...
Mbusa Wasukundi, Marie Caroline Momo Solefack, Chadrack Kafuti, Hans Beeckman, Nils Bourland, Jean‐Pierre Mate Mweru, Benoît Jourez, Kévin Liévens, Michael Monnoye, Félix Laurent, Falonne Osiveri, Robin Doucet, Paul Katembo Vikanza, Silvia Ferrari, Jean Gérard, Nestor Luambua, Joris Van Acker, Jan Van den Bulcke, Wannes Hubau, Tom De Mil   +19 more
wiley   +1 more source

Tissue-resident memory T cell signatures from single-cell analysis associated with better melanoma prognosis

iScience
Summary: Tissue-resident memory T cells (TRM) are a specialized T cell population residing in peripheral tissues. The presence and potential impact of TRM in the tumor immune microenvironment (TIME) remain to be elucidated.
Chongming Jiang, Cheng-Chi Chao, Jianrong Li, Xin Ge, Aidan Shen, Vadim Jucaud, Chao Cheng, Xiling Shen   +7 more
doaj   +1 more source

Strengthening of punching shear of flat slab–column connections through hybrid near‐surface mounted and externally bonded systems: Experimental, numerical, and analytical study

Structural Concrete, EarlyView.
Abstract Slab–column connections are vulnerable to punching shear, particularly when flexural cracking reduces the effective depth. This study proposes a sustainable dual‐strengthening system to enhance punching resistance and combined flexural–punching performance.
Ahmed Hamoda, Mizan Ahmed, Aref A. Abadel, Saad A. Yehia   +3 more
wiley   +1 more source

CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice

Medical Microbiology and Immunology, 2019
Cytomegalovirus (CMV) infection is a significant public health problem. Congenital CMV infection is a leading infectious cause of long-term neurodevelopmental sequelae, including mental retardation and sensorineural hearing loss. Immune protection against mouse cytomegalovirus (MCMV) is primarily mediated by NK cells and CD8+ T cells, while CD4+ T ...
Brizić, Ilija, Hiršl, Lea, Šustić, Marko, Golemac, Mijo, Britt, William J., Krmpotić, Astrid, Jonjić, Stipan   +6 more
openaire   +5 more sources

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Every breath you take: The impact of environment on resident memory CD8 T cells in the lung

Frontiers in Immunology, 2014
Resident memory T cells (TRM) are broadly defined as a population of T cells which persist in non-lymphoid sites long term, do not re-enter the circulation, and are distinct from central memory T cells (TCM) and circulating effector memory T cells (TEM).
Hillary eShane, Kim eKlonowski
doaj   +1 more source

Updates in acute graft‐versus‐host disease: From novel pathogenic mechanisms to emerging therapeutic targets

British Journal of Haematology, EarlyView.
The graphical abstract provides a view on selected aspects of the pathogenesis, risk stratification and treatment of acute GVHD. Summary Acute graft‐versus‐host disease (aGVHD) remains a major complication following allogeneic haematopoietic stem cell transplantation (allo‐HSCT), representing a leading cause of non‐relapse mortality (NRM) and ...
Hazim Khatib, Robert Zeiser
wiley   +1 more source