Results 101 to 110 of about 4,753,527 (236)
Cell Communication and SignalingBackground Allergic asthma is a chronic airway disease characterized by an allergic response and altered immune tolerance. CD4+ tissue-resident memory T (TRM) cells are crucial in the chronic and relapsing pathogenesis of asthma.
Meng Zhang +9 more
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, 2022 Growing lines of evidence supported the importance of CD8+ lung tissue resident memory T (TRM) cells in protection against respiratory viruses, exemplified by influenza A virus. However, the underlying in vivo mechanism remains largely undetermined. Here,
Linxia Zhang (268826) +10 more
core +1 more source
Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes +7 more
wiley +1 more source
Immunological pathogenesis of inflammatory bowel disease: focus on tissue resident memory T cells
Frontiers in ImmunologyTissue-resident memory T (TRM) cells are a type of tissue-restricted memory T cells with terminal differentiation and a memory function. They exist in mucosal tissues for a long period. In the absence of disease, TRM cells promote essential inflammation,
Jiayan Hu +12 more
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European Journal of Haematology, EarlyView.ABSTRACT Objectives Primary plasma cell leukemia (pPCL) is a rare disease with poor outcomes. As data on randomized phase‐III trials are lacking, treatment recommendations are predominately based on retrospective analyses incorporating time periods with outdated therapies. Thus, the optimal consolidation strategy remains to be defined.
Maria Dampmann +16 more
wiley +1 more source
Tissue‐resident memory T cells in diseases and therapeutic strategies
MedCommTissue‐resident memory T (TRM) cells are crucial components of the immune system that provide rapid, localized responses to recurrent pathogens at mucosal and epithelial barriers. Unlike circulating memory T cells, TRM cells are located within peripheral
Daoyuan Xie +4 more
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Evaluation of Discontinuation and Re‐Initiation of Biologic Therapies in Psoriasis: Real‐World Data
International Journal of Dermatology, EarlyView.The cumulative probability of remaining relapse‐free following biologic therapy discontinuation was 35.6%, 19%, 11.6%, and 9.1% at 6, 12, 18, and 24 months, respectively. Prolonged relapse durations were associated with a low baseline PASI score, the presence of a PASI 90 response at discontinuation, the absence of triggering factors, and the use of IL‐
Ahmet Taha Aydemir, Nihal Kundakcı
wiley +1 more source
Tissue Resident Memory Cells: Friend or Foe?
Immunology, EarlyView.Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude +2 more
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Murine CMV Infection Induces the Continuous Production of Mucosal Resident T Cells
Cell Reports, 2015 Cytomegalovirus (CMV) is a herpesvirus that persists for life and maintains extremely large numbers of T cells with select specificities in circulation. However, it is unknown how viral persistence impacts T cell populations in mucosal sites.
Corinne J. Smith +3 more
doaj +1 more source
Early systemic intervention for vitiligo: A prospective bicentric interventional study
Journal of the European Academy of Dermatology and Venereology, EarlyView.Patients with non‐segmental vitiligo were enrolled into three groups according to the duration and activity of their disease. All subjects received NB‐UVB phototherapy and an oral mini‐pulse of systemic corticosteroids twice weekly for 6 months. Early systemic treatment allows better repigmentation, including in difficult‐to‐treat areas.
Clemence Bertold +8 more
wiley +1 more source