Results 121 to 130 of about 4,753,527 (236)

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Lipidomics of orchid seeds: from development to storage

Plant Biology, EarlyView.
The study tracked lipid changes from pollination to storage in two orchid species. Although both were desiccation‐tolerant and storable, differences in saturated and unsaturated fatty acid proportions during development led to different moisture contents and germination capacities.
C. C. Custódio, N. B. Machado‐Neto, L. Colville, P. T. Seaton, H. W. Pritchard, T. R. Marks   +5 more
wiley   +1 more source

Vaccine-driven lung TRM cells provide immunity against Klebsiella via fibroblast IL-17R signaling. [PDF]

Sci Immunol, 2021
Iwanaga N, Chen K, Yang H, Lu S, Hoffmann JP, Wanek A, McCombs JE, Song K, Rangel-Moreno J, Norton EB, Kolls JK.   +10 more
europepmc   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

GL7 ligand expression defines a novel subset of CD4⁺ T_RM cells in lungs recovered from pneumococcus. [PDF]

Mucosal Immunol, 2023
Lyon De Ana C, Shenoy AT, Barker KA, Arafa EI, Etesami NS, Korkmaz FT, Soucy AM, Breen MP, Martin IMC, Tilton BR, Devarajan P, Crossland NA, Pihl RMF, Goltry WN, Belkina AC, Jones MR, Quinton LJ, Mizgerd JP.   +17 more
europepmc   +1 more source

The Direction of the Clostridioides difficile–Gastrointestinal GVHD Relationship After Allogenic Hematopoietic Cell Transplantation: A Time‐Dependent CIBMTR Analysis

Transplant Infectious Disease, EarlyView.
In 7175 allogeneic transplant recipients, gastrointestinal graft‐versus‐host disease increased the risk of subsequent Clostridioides difficile infection, but CDI did not predict later GVHD. The direction emerged only when timing was respected; an apparent PTCy association disappeared once CDI diagnosed before the drug was given was excluded.
Aseel H. Alzibdeh, Ahmed Zaqout, Samar Hashim, Maha AlJabri, Suleiman AbuJarir, Mohammad Bakir, Muna AlMaslamani, Ali S. Omrani   +7 more
wiley   +1 more source

Palmitoylation induced activation of SMAD3 exacerbates colitis by promoting TRM cells differentiation

Abstract Tissue-resident memory T cells (TRM cells) have been shown to play an instrumental role in driving the onset and relapse of inflammatory bowel diseases (IBD). However, the underlying mechanism of TRM cells differentiation and its regulation in intestines remain to be unveiled.
Yuejie Xu, Siqi Ji, Ping Jiang, Zhenguo Zhao, Qian Zhou, Dan Su, Yu Zhao, Xiaoping Zou, Mingming Zhang, Jing Sun, Guifang Xu, Tang Jian   +11 more
openaire   +1 more source

Quality without a mandate: An exploratory national survey of perioperative autologous transfusion accreditation barriers

Transfusion, EarlyView.
Abstract Background Perioperative autologous transfusion, encompassing intraoperative cell salvage (ICS), acute normovolemic hemodilution (ANH), and autologous component production, is integral to patient blood management. Association for the Advancement of Blood and Biotherapies (AABB) has published comprehensive quality standards, yet perioperative ...
Gagan Mathur, Nada Naiyer, Patricia Travassos, Jennifer O'Brien, Tonya Nuelle, Allan Klompas, Muharrem Yunce, David Moolten   +7 more
wiley   +1 more source

Numerical, phenotypic and functional differences in human dermal resident memory T cells between reticular dermal layers

Skin Health and Disease
Background Resident memory T (TRM) cells and immunosuppressive Foxp3‐expressing regulatory TRM (regTRM) cells are present in healthy, non‐inflamed and inflamed human skin.
Takuya Sato, Riko Asakawa, Youichi Ogawa, Yuka Nagasaka, Manao Kinoshita, Shinji Shimada, Akira Momosawa, Tatsuyoshi Kawamura   +7 more
doaj   +1 more source

VEGF inhibitor‐induced vascular dysfunction involves redox‐sensitive PARP activation and SIRT1 disruption

Experimental Physiology, EarlyView.
Abstract Vascular endothelial growth factor receptor (VEGFR) inhibitors are effective antiangiogenic agents used in cancer therapy. However, they are associated with cardiovascular disease, including hypertension and vascular dysfunction. The molecular mechanisms underlying these cardiovascular toxicities are unclear, but oxidative stress might be ...
Karla B. Neves, Rheure Alves‐Lopes, Augusto C. Montezano, Rhian M. Touyz   +3 more
wiley   +1 more source