Results 131 to 140 of about 4,753,527 (236)

Cutting Edge: Influenza-Induced CD11alo Airway CD103+ Tissue Resident Memory T Cells Exhibit Compromised IFN-γ Production after In Vivo TCR Stimulation. [PDF]

J Immunol, 2023
van de Wall S, Crooks S, Varga SM, Badovinac VP, Harty JT.   +4 more
europepmc   +1 more source

Intrahepatic Tissue‐Resident CD8+ T‐Cell Programmes Associate With Fibrosis and Local Immune Remodelling in Autoimmune Hepatitis [PDF]

Liver Int
ABSTRACT Background and Aims Autoimmune hepatitis is an immune‐mediated liver disease characterized by chronic inflammation and progressive fibrosis. Tissue‐resident memory T cells mediate organ‐specific immunity, but their role in autoimmune hepatitis remains poorly understood.
Stary V, Losek S, Mairinger M, Prager G, Santol J, Starlinger P, Reiberger T, Stättermayer A, Stary G.   +8 more
europepmc   +2 more sources

TRM cells hit the road [PDF]

Nature Immunology, 2019
openaire   +2 more sources

Cutaneous T Cells in Skin Immunity | TRM Cells and CTCL Insights

Explore the roles of cutaneous T cells in skin immunity, focusing on TRM cells, the cutaneous immune system, key T-cell markers, and the pathogenesis of cutaneous T-cell lymphoma (CTCL).
openaire   +1 more source

Ascending infection of Gardnerella spp. and compartmentalized inflammatory response in fetal–maternal interface organ‐on‐chip model

The Journal of Physiology, EarlyView.
Abstract figure legend The fetal–maternal interface organ‐on‐chip was used to investigate the ascending infection of Gardnerella spp. across the decidua (DEC), chorion trophoblast (CTC), amnion mesenchymal (AMC) and amnion epithelial (AEC) compartments over 48 h.
Mariana de Castro Silva, Jeniffer Sena Baptista Ferreira, Rafael Gomes Barnabé, Maria Eduarda Tesini Rocha, Laura Emi Yonezawa de Souza, Bruna Ribeiro de Andrade Ramos, Ramkumar Menon, Márcia Guimarães da Silva   +7 more
wiley   +1 more source

Single-cell analysis of CD4+ tissue residency memory cells (TRMs) in adult atopic dermatitis: A new potential mechanism

Genomics
The pathophysiology of atopic dermatitis (AD) is complex. CD4+ T cells play an essential role in the development of lesions in AD. However, the underlying mechanism remains unclear. In the present study, we investigated the differentially expressed genes (DEGs) between adult AD lesioned and non-lesioned skin using two datasets from the Gene Expression ...
Wenxuan, Bai, Le, Yang, Jing, Qiu, Zihan, Zhu, Shuxing, Wang, Peidi, Li, Dawei, Zhou, Hongyi, Wang, Yuxuan, Liao, Yao, Yu, Zijiang, Yang, Puqiao, Wen, Di, Zhang   +12 more
openaire   +2 more sources

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source

Multifaceted functions of tissue-resident memory T cells in tumorigenesis and cancer immunotherapy

Cancer Immunology, Immunotherapy
Tissue-resident memory T (TRM) cells are well reported as a strong protective first line of defense against foreign antigens in non-lymphoid tissues. Moreover, TRM cells have demonstrated critical protective roles in antitumor immunity, contributing to ...
Eun Sang Seo, Sung-Kyu Lee, Young Min Son   +2 more
doaj   +1 more source

IL-15 supports the generation of protective lung-resident memory CD4 T cells

, 2018
Tissue-resident memory T cells (TRM) provide optimal defense at the sites of infection, but signals regulating their development are unclear, especially for CD4 T cells. Here we identify two distinct pathways that lead to the generation of CD4 TRM in the
Strutt, T. M., Dhume, K., Castonguay, Catherine, Swain, Susan L, Finn, C. M., Hwang, J. H., McKinstry, K. K.   +6 more
core   +1 more source

A Confirmatory, Dual Center Nonhuman Primate Study on the Efficacy of Novel Oropharyngeal Spray Immunization With an Adenoviral Vector Vaccine Against RSV—Important Lessons Learned

Journal of Medical Primatology, Volume 55, Issue 6, December 2026.
ABSTRACT Background In a randomized, blinded, dual center study across two European primate research facilities, we evaluated the immunogenicity and protective efficacy of a DNA prime—oropharyngeal adenoviral boost vaccination strategy against respiratory syncytial virus (RSV).
Matthias Tenbusch, Gerrit Koopman, Petra Mooij, Berit Roshani, Pascal Irrgang, Dennis Lapuente, Ivanela Kondova, Willy M. Bogers, Edmond J. Remarque, Ramona Vestweber, Samuel Alberto Merida Ruiz, Nadine Krüger, Sebastian Meyer, Olaf Gefeller, Christiane Stahl‐Hennig, Klaus Überla   +15 more
wiley   +1 more source