Results 141 to 150 of about 4,753,527 (236)

Single-cell analysis indicating CCR8 modulates CD8+ tissue-resident memory T cells to attenuates rejection in transplantation

Scientific Reports
Immune rejection poses a major challenge in organ transplantation, with tissue-resident memory T (TRM) cells playing a critical role in graft rejection. This study investigated the impact of CCR8 on TRM cells using single-cell RNA sequencing (scRNA-seq),
Xueteng Wang, Xinqiang Li, Hailun Cai, Zhuoyu Jia, Xin Zhou, Ruidong Ding, Meiying Song, Huan Liu, Feng Wang, Bin Wu, Kai Zhao, Shipeng Li, Bei Zhang, Dahong Teng, Jinzhen Cai   +14 more
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Seedy CD8+ T_RM cells in aging lungs drive susceptibility to pneumonia and sequelae. [PDF]

Cell Mol Immunol, 2021
Shenoy AT, Mizgerd JP.
europepmc   +1 more source

A Pathogenic CD8+ TRM–Chemokine Axis Orchestrates Liver Fibrosis and Provides Circulating Biomarkers during Chronic Clonorchis sinensis Infection [PDF]

Chronic liver fluke infections represent a major global health burden, driving liver fibrosis and elevating cancer risk, yet the immunological mechanisms linking persistent infection to tissue damage remain poorly defined.
Helmby, Helena, Chen, Guangjie, Li, Yuanyuan, Wang, Xin, Ye, Youqiong, Li, Jiashun, Yi, Haibo, Gao, Yuwei, Li, Xiangwei, Wassmer, Samuel C, Niu, Xiaoyin, Qian, Menbao, Wang, Zhaojun, Zhu, Tingjun, Du, Xinyue, Wu, Wenyu, Wu, Chenyun, Yan, Huibo, Sripa, Banchob, Kassegne, Kokouvi   +19 more
core  

Neoadjuvant Therapy for Non‐Small Cell Lung Cancer: Recent Advances and Future Directions

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Neoadjuvant therapy has become an integral component of the multidisciplinary management of resectable non–small cell lung cancer (NSCLC). The introduction of immune checkpoint inhibitors (ICIs) has transformed the perioperative treatment landscape by improving pathological response rates, reducing the risk of recurrence, and offering the ...
Hao An, Junfeng Zhao, Wenjie Chen, Ying Li, Yifei Yan, Chen Zhou, Ruyue Li, Xiujing Yao, Xue Dong, Xingying Yang, Yongjuan Hu, Jiaxuan Chen, Chuankun Han, Yingrui Bai, Yali Xu, Yintao Li   +15 more
wiley   +1 more source

Factors governing CD8+ resident memory (Trm) cell retention and migration in tumors and draining lymph nodes 2260863

Introduction CD8+ resident memory (Trm) cells are critical mediators of anti-tumor immunity. However, it remains unclear whether canonical memory T cell features, namely antigen independence and durable persistence, apply to Trm cells
Christo Dragnev, Wilson Davis, Neeti Mittal, Weile Gao, Mary Jo Turk, Janet Dickman, Christina Angeles, Abhishek Mangipudi, Joseph Phillips, Tyler Searles   +9 more
core   +1 more source

ScRNA‐Seq Reveals Jiangfu Zhixie Formula Alleviates IBS‐D by Inhibiting Macrophage M1 Polarization through HIF‐1α‐Glycolysis Axis

Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.
ABSTRACT Background Irritable bowel syndrome with diarrhea (IBS‐D) remains a challenging condition to manage due to its chronic nature and the limited long‐term efficacy of current treatments. The traditional Chinese herbal formula Jiangfu Zhixie (JFZX) has shown clinical benefits, but its underlying mechanisms remain unclear.
Xiaosong Xu, Yao Du, Lipeng Du, Wanning Zhang, Bowen Guo, Yanru Cai, Tianyi Zhang   +6 more
wiley   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 9, Page 913-932, November 2026.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Functionally Competent, PD-1⁺ CD8⁺ Trm Cells Populate the Brain Following Local Antigen Encounter. [PDF]

Front Immunol, 2020
Schøller AS, Nazerai L, Christensen JP, Thomsen AR.   +3 more
europepmc   +1 more source