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HIV Specific CD8+ TRM-Like Cells in Tonsils Express Exhaustive Signatures in the Absence of Natural HIV Control [PDF]

Frontiers in Immunology, 2022
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of great ...
Rishan Bipath, Alveera Singh, Ntombifuthi Mthabela   +2 more
exaly   +3 more sources

The Role of Circulating T Cells With a Tissue Resident Phenotype (Ex-TRM) in Health and Disease [PDF]

Frontiers in Immunology
Tissue-resident memory T cells (TRM) are long-lived memory lymphocytes that persist in non-lymphoid tissues and provide the first line of defence against invading pathogens.
Andrew J. Stagg, James O Lindsay
exaly   +4 more sources

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TRM cells: not born this way

Trends in Immunology, 2023
Human tissue-resident memory T (TRM) cells seeded early in life undergo an age-associated functional maturation and residency acquisition throughout childhood.
Allison, Clatch, Susan N, Christo, Laura K, Mackay   +2 more
openaire   +2 more sources

CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched With Tc17

Cell Reports Medicine, 2020
International audienceAccumulation of CD103+CD8+ resident memory T (TRM) cells in human lung tumors has been associated with a favorable prognosis. However, the contribution of TRM to anti-tumor immunity and to the response to immune checkpoint blockade ...
Benjamin Besse, Fathia Mami-Chouaib, David Planchard   +2 more
exaly   +2 more sources

Epithelial antigen presentation regulates CD4+ TRM cell locations, functions and activities

The Journal of Immunology, 2021
Abstract Barrier tissues are sentinelled by CD4+ TRM cells with potent anti-microbial activities and considerable lineage plasticity. We hypothesized that local antigen presentation by lung epithelial cells (LECs) instruct CD4+ TRM cell activities.
Anukul T Shenoy, Emad I Arafa, Carolina Lyon De Ana, Kimberly A Barker, Filiz T Korkmaz, Aditya Ramanujan, Neelou S Etesami, Ian M C Martin, Brian R Tilton, Anne Hinds, Wesley N Goltry, Hasmeena Kathuria, Matthew R Jones, Lee J Quinton, Anna C Belkina, Joseph P Mizgerd   +15 more
openaire   +1 more source

CD8+ TRM-derived IFNγ is a critical activator of human lung epithelial cells

The Journal of Immunology, 2023
Abstract Due to their position in the pulmonary mucosa, CD8+ tissue resident memory T cells (TRM) act as sentinels that rapidly respond to, and mediate protection against, respiratory viruses. In mice, TRM have been shown to mediate protection at barrier sites by producing cytokines, chemokines, and performing cell lysis.
Cameron Mattingly, Jennifer Elliott, Jeronay Thomas, Jenna Lobby, Sarah Michalets, Kirsten N Kost, Jacob E Kohlmeier   +6 more
openaire   +1 more source

HBV-Specific Trm Cells Correlate with Relapse-Free Survival in HCC

Cancer Discovery, 2021
Abstract Infiltrating HBV-specific CD8+ Trm cells correlated with improved relapse-free survival in HCC.
openaire   +2 more sources