Results 201 to 210 of about 4,753,527 (236)
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Tumor-Embedded Immunity and TRM Cell Functions in Cancer
Mini-Reviews in Medicinal ChemistryIn the ongoing battle between the immune system and cancer, a unique subset of T cells has quietly emerged as a key player. Tissue-Resident Memory T (TRM) cells, strategically positioned within tissues, are redefining our understanding of localized immune defense and tumor control.
Ashiq Ali, Kaynaat Akbar
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Abstract 1343: CD8+ resident memory T (TRM) cells in tumors
Cancer Research, 2022Abstract Tumor-resident memory T (TRM) cells play an important role in cancer diseases. Accumulating evidence indicates that subpopulations of CD3+CD8+ tumor-infiltrating lymphocytes (TIL) are TRM cells, and are emerging as activated tumor-specific T cells.
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Current Opinion in Immunology
Tissue resident memory T cells (TRM) cells are a recently defined subtype of nonrecirculating memory T cells with longevity and protective functions in peripheral tissues. The discovery of T cells resident in diverse tissues has altered our understanding of adaptive immunity with respect to site-specific immune response.
Siba P, Raychaudhuri +1 more
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Tissue resident memory T cells (TRM) cells are a recently defined subtype of nonrecirculating memory T cells with longevity and protective functions in peripheral tissues. The discovery of T cells resident in diverse tissues has altered our understanding of adaptive immunity with respect to site-specific immune response.
Siba P, Raychaudhuri +1 more
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CD4+ T cells regulate skin resident memory CD8+ T cells (TRM) (49.8)
The Journal of Immunology, 2012Abstract The requirement of CD4+ T cell help for CD8+ T cell responses has been extensively explored in secondary lymphoid organs using systemic infection models. Whether such help also exists in peripheral tissues like the skin is unknown. We recently reported that skin resident memory CD8+ T cells (TRM) are non-recirculating and are
Xiaodong Jiang +7 more
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Resident memory (TRM) cells sustain immunity to cancer at sites of frequent metastasis
The Journal of Immunology, 2019Abstract Tissue resident memory T cells (TRM cells) have recently been recognized as durable mediators of immunity to cancer. We previously showed that regulatory T cell-depleting immunotherapy of B16 melanoma induces protective TRM cells that persist in the skin of mice that develop autoimmune vitiligo. The goal of the present study was
Aleksey Molodtsov +11 more
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JHEP ReportsBackground & Aims: Tissue-resident memory T cells (TRMs) are long-lived cells poised for rapid immune responses to pathogens. This study assesses whether peritoneal CD8 T cells from patients with cirrhosis exhibit TRM-like functionalities, focusing ...
Sabine Baumgart +2 more
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PD-1 Is Requisite for Skin TRM Cell Formation and Specification by TGFβ
Nature ImmunologyTissue-resident memory T (TRM) cells provide infectious, cancer and vaccine-trained immunity across barrier sites. TRM cells are implicated in autoimmunity, successful response to immune checkpoint blockade in the tumor microenvironment and toxicities that occur after immune checkpoint blockade in peripheral tissues.
Mayte Suárez-Fariñas +2 more
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The Journal of Immunology
Abstract Description Tissue-resident memory (TRM) CD8+ T cells in the lungs rapidly respond to influenza reinfection. TRM can express tissue-binding integrins CD49a/CD29 and CD103/B7. When and where TRM develop and acquire their phenotype is debated.
Taylor Nancy Jones +2 more
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Abstract Description Tissue-resident memory (TRM) CD8+ T cells in the lungs rapidly respond to influenza reinfection. TRM can express tissue-binding integrins CD49a/CD29 and CD103/B7. When and where TRM develop and acquire their phenotype is debated.
Taylor Nancy Jones +2 more
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Tissue-Resident Trouble: How TRM Cells Drive Allergic Contact Dermatitis
Current Treatment Options in AllergyCharlotte Menné Bonefeld +2 more
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The Journal of Immunology, 2018
Abstract Tissue-resident memory CD8+ T cells (TRM) confer rapid protection and immunity against viral infections. Many viruses have evolved mechanisms to inhibit MHCI presentation in order to evade effector CD8+ T cells, suggesting that these mechanisms may also apply to TRM-mediated protection.
Elvin James Lauron +5 more
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Abstract Tissue-resident memory CD8+ T cells (TRM) confer rapid protection and immunity against viral infections. Many viruses have evolved mechanisms to inhibit MHCI presentation in order to evade effector CD8+ T cells, suggesting that these mechanisms may also apply to TRM-mediated protection.
Elvin James Lauron +5 more
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