Results 181 to 190 of about 45,835 (226)

tRNA-derived fragments: mechanism of gene regulation and clinical application in lung cancer. [PDF]

Cell Oncol (Dordr)
Wu F, Yang Q, Pan W, Meng W, Ma Z, Wang W.   +5 more
europepmc   +1 more source

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, Volume 13, Issue 46, 17 August 2026.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation

Advanced Science, Volume 13, Issue 45, 13 August 2026.
G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang, Qingqing Xu, Yuxin Zhang, Fang Liu, Guangchao Sui, Dangdang Li   +5 more
wiley   +1 more source

5’tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes

Cosentino C, Klein R, Menoud V, Guay C, Aiello E, Auddino S, Di Giuseppe G, Ciccarelli G, Galli A, Alabiso F, Mangano E, Brozzi F, Bouzakri K, D’Adamo S, Cetrullo S, Quero G, Mari A, Alfieri S, Giaccari A, Mezza T, Dotta F, Sebastiani G, Regazzi R.   +22 more
europepmc   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, Volume 9, Issue 8, Page 1648-1660, August 2026.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Condensates on the Move: Midbody Remnants as Large, Translation‐Competent Extracellular Vesicles

BioEssays, Volume 48, Issue 8, August 2026.
Mitotic cells produce three EV types: exosomes and microvesicles (green/blue) delivering pre‐formed molecules, and midbody remnants (magenta) containing functional ribosomes and translation machinery within biomolecular condensates. Unlike passive cargo carriers, MBRs actively synthesize proteins after release, transforming from cellular debris to ...
Ahna R. Skop
wiley   +1 more source

IMACulate(DE3), an E. coli Strain for High Purity His‐Tagged Protein Purifications

Biotechnology and Bioengineering, Volume 123, Issue 8, Page 2127-2138, August 2026.
ABSTRACT Immobilised Metal Affinity Chromatography (IMAC) is widely used to purify his‐tagged recombinant proteins from Escherichia coli. However, endogenous contaminants with histidine clusters, such as GFAT and PDH E1 proteins, are often co‐purified with the target protein.
Jia Q. Truong, Dingyi Yu, Nan Hao, Chris Langendorf, Keith. E. Shearwin, Jessica K. Holien   +5 more
wiley   +1 more source

Lippia umbellata Cav.: Chemical Composition, Insecticidal, and Antimicrobial Activities

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Hexane extracts of Lippia umbellata leaves and flowers contain lupenone, α‐amyrin, and hentriacontane. They exhibit insecticidal activity against Drosophila melanogaster and inhibit AChE in vitro and in silico. Furthermore, the extracts can inhibit the growth of medically important bacteria and yeasts, including multidrug‐resistant strains.
José Guillermo Avila‐Acevedo, Miriam Arlette López‐Pérez, Ana Karen Villagómez‐Guzmán, Edgar Antonio Estrella‐Parra, Nallely Álvarez‐Santos, Israel Valencia‐Quiroz, Julieta Orozco‐Martínez, Ma. Edith López‐Villafranco, Silvia Aguilar‐Rodríguez, Carlos Leonardo Céspedes‐Acuña, Juio Alarcón‐Enos, Ana María García‐Bores   +11 more
wiley   +1 more source

The Complete Chloroplast Genome Sequences of Salvia reflexa and Genome Comparison: Implications for Phylogeny and Plant Invasion

Ecology and Evolution, Volume 16, Issue 8, August 2026.
This study reports the complete chloroplast genome of Salvia reflexa and compares it with those of other invasive and non‐invasive Salvia species to explore genomic features associated with invasiveness. The chloroplast genome exhibits a typical quadripartite structure and shows high conservation within the genus, while several hypervariable regions ...
Lina Ding, Tianhe Yang, Shuai Wang, Hanyue Zhou, Ran Xin, Qing Miao, Ping Guan, Bo Qu   +7 more
wiley   +1 more source

Mitogenomics of Culex pipiens Form Pipiens From the Turkish Black Sea Region Reveals Structural Conservation and Phylogenetic Complexity

Ecology and Evolution, Volume 16, Issue 8, August 2026.
Complete mitochondrial genomes of five Turkish Culex pipiens form pipiens isolates from the Black Sea region revealed highly conserved mitogenome architecture. Expanded comparisons across the broader Cx. pipiens complex showed that mitochondrial diversity was concentrated in selected loci and terminal regions associated with the A + T‐rich control ...
Ahsen Meliha Toroslu, Alparslan Yildirim, Gokmen Zafer Pekmezci, Osman Ibis, Samba Deguene Diop, Batuhan Askim Arslanhan, Saffet Teber, Alina Denis Kizgin, Simge Sahin, Filiz Gunay, Nathan Burkett‐Cadena, Lindsay Campbell, Abdullah Inci, Barry Wilmer Alto   +13 more
wiley   +1 more source