Results 201 to 210 of about 45,835 (226)

Transfer RNA‐derived fragments as potential exosome tRNA‐derived fragment biomarkers for osteoporosis

International Journal of Rheumatic Diseases, 2018
AbstractAimOsteoporosis is one of the common orthopedic diseases featured in low bone mineral density. Exosomes have been proven to be potential markers for many diseases and health problems. The roles of messenger RNAs and microRNAs in osteoporosis have been comprehensively studied; however, little research has focused on the function of plasma ...
Yan Zhang, Feng Cai, Ju Liu, Hongze Chang, Liang Liu, Anli Yang, Xiaodong Liu   +6 more
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tRNA-derived fragments (tRFs) contribute to podocyte differentiation

Biochemical and Biophysical Research Communications, 2020
Loss of glomerular podocytes is the crucial event in the progression of chronic kidney disease (CKD). tRNA-derived fragments (tRFs), a newfangled branch of small non-coding RNA (sncRNA), recently reported to play a vital part in several diseases. In present study, we aimed to detect and reveal the role of tRFs in podocyte differentiation.
Huimin, Shi, Minyi, Yu, Yue, Wu, Yuepeng, Cao, Shanwen, Li, Gaoting, Qu, Jing, Gong, Weihua, Gan, Aiqing, Zhang   +8 more
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The functions of a 5′ tRNA-Ala-derived fragment in gene expression

Plant Physiology, 2023
Abstract Transfer RNA (tRNA) can produce smaller RNA fragments called tRNA-derived fragments (tRFs). tRFs play critical roles in multiple cellular programs, although the functional mechanisms of tRFs remain largely unknown in plants. In this study, we examined the phenotype associated with 5′ tRF-Ala (tRF-Ala, produced from tRNA-Ala ...
Yuanyuan Li, Junping Gao, Ying Wang, Jun Cai, Dousheng Wu, Long Wang, Wenxuan Pu, Feng Yu, Sirui Zhu   +8 more
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Identification of tRNA-Derived Fragments in Legumes

The tRNA-derived noncoding RNAs (tncRNAs) belong to the novel class of noncoding RNAs, acting as important components of genome regulatory circuits. In planta, the mechanism of generation and function of tncRNAs is not fully elucidated. Production of important leguminous plants like chickpea, Medicago and soybean is majorly hampered due to different ...
Simran Arora, Sahrish Aftab, Tanu Shree, Shailesh Kumar   +3 more
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Biochemical properties and progress in cancers of tRNA‐derived fragments

Journal of Cellular Biochemistry, 2019
AbstracttRNA‐derived small RNAs (tRFs), a kind of noncoding RNAs, are generated from transfer RNAs. tRFs have some types according to their source and sizes. They play important roles in cell life and carcinogenesis. In this paper, we review the biogenesis and biological properties.
Zhongliang Ma, Jinbao Zhou, Yang Shao, Fatemah.A. Jafari, Pengfei Qi, Yanli Li   +5 more
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Relationship between tRNA‐derived fragments and human cancers

International Journal of Cancer, 2020
AbstracttRNA‐derived fragments, a class of small noncoding RNAs (sncRNAs), have been identified in numerous studies in recent years. tRNA‐derived fragments are classified into two main groups, including tRNA halves (tiRNAs) and tRNA‐derived small RNA fragments (tRFs), according to different cleavage positions of the precursor or mature tRNAs.
Tianyu Zeng, Yijia Hua, Chunxiao Sun, Yuchen Zhang, Fan Yang, Mengzhu Yang, Yiqi Yang, Jun Li, Xiang Huang, Hao Wu, Ziyi Fu, Wei Li, Yongmei Yin   +12 more
openaire   +2 more sources

PtRFdb: Plant tRNA-Derived Fragments Database

2019
The transfer RNA-derived fragments or tRFs represent a distinct class of small non-coding RNAs, and have been detected in evolutionarily divergent organisms. The role of tRFs in human cancers and infectious diseases as well as in gene regulation has been well established in diverse organisms.
Shafaque Zahra, Shailesh Kumar
openaire   +1 more source

tRNA-derived fragments: biomarkers and therapeutic targets in autoimmune diseases

Immunologic Research
TRNA-derived fragments (tRFs) are tiny non-coding RNAs that control gene expression and immunological responses. Initially, the tRFs were thought to be only a byproduct of Transfer RNA (tRNA) degradation. Recent studies highlighted their role in autoimmune diseases like type 1 diabetes (T1D), inflammatory bowel disease (IBD), rheumatoid arthritis (RA),
Akanksha, Kaimwal, Muhammed, Hadish, Anil, Kumar, Ajay, Kumar, Anjana, Munshi   +4 more
openaire   +2 more sources

Genetic Control of tRNA-Derived Fragments Contributes to Cancer Risk

Cancer Research
Abstract tRNA-derived fragments (tRF) are a class of small noncoding RNAs that have exhibited several functions in cancer. Recent studies have shown that mutations in tRNA genes can lead to global changes in tRF expression levels and may affect tRF function, highlighting the need to further ...
Bin Li, Hanting Li, Yan Li, Zhirui Chen, Danyi Zou, Chunyi He, Songqiang Li, Kexin Hu, Caibo Ning, Yanmin Li, Hui Geng, Shuhui Yang, Chaoqun Huang, Xiaojun Yang, Qiuhong Wang, Xu Zhu, Xiangpan Li, Ying Zhu, Meng Jin, Xiaoping Miao, Jianbo Tian   +20 more
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Small Noncoding RNAs in Knee Osteoarthritis: The Role of MicroRNAs and tRNA-Derived Fragments

International Journal of Molecular Sciences, 2021
Paweł Bakowski, Anna Maria Mleczko, Kamilla Grzywacz   +2 more
exaly