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Food Science &Nutrition, Volume 14, Issue 8, August 2026.Summary schematic illustrating the proposed association among dietary LBP intake, gut microbiota remodeling, fecal metabolic pathway modulation, retinal metabolite changes, and retinal antioxidant signaling. The model summarizes associations observed in the present study and does not imply direct causal proof.
Yijing Yang +8 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger +18 more
wiley +1 more source
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Roles of tRNA-derived fragments in human cancers
Cancer Letters, 2018Transfer RNAs (tRNAs) were traditionally considered to participate in protein translation. Recent studies have identified a novel class of small non-coding RNAs (sncRNAs), produced by the specific cleavage of pre- and mature tRNAs, which have been named tRNA-derived fragments.
Yongmei Yin, Chunxiao Sun
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AbstractAimsMaternally inherited diabetes and deafness (MIDD) is a rare form of adult‐onset diabetes that can be difficult to diagnose due to its variable clinical phenotype. Transfer RNA‐derived small fragments are a novel, emerging class of small non‐coding RNAs (sncRNAs) that have significant potential as serum biomarkers due to their stress‐induced
N. Ng +7 more
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Role of tRNA-Derived Fragments in Neurological Disorders: a Review
Molecular Neurobiology, 2022tRFs are small tRNA derived fragments that are emerging as novel therapeutic targets and regulatory molecules in the pathophysiology of various neurological disorders. These are derived from precursor or mature tRNA, forming different subtypes that have been reported to be involved in neurological disorders like stroke, Alzheimer's, epilepsy, Parkinson'
Blessy Aksa Mathew +4 more
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Identification of tRNA-derived Fragments and Their Potential Roles in Atherosclerosis
Current Medical Science, 2021Atherosclerosis (AS), a chronic inflammatory disease, is the basis of cardiovascular disease (CVD). Although the treatment has been greatly improved, AS still imposes a large burden on human health and the medical system, and we still need to further study its pathogenesis.
Jian, Wang +12 more
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Differential expression of human tRNA genes drives the abundance of tRNA-derived fragments [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 The human genome encodes hundreds of transfer RNA (tRNA) genes but their individual contribution to the tRNA pool is not fully understood. Deep sequencing of tRNA transcripts (tRNA-Seq) can estimate tRNA abundance at single gene resolution, but tRNA structures and posttranscriptional modifications impair these analyses. Here we present a bioinformatics
Camille Stephan-Otto Attolini +2 more
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tRNA-derived fragments and tRNA halves: The new players in cancers
Cancer Letters, 2019tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are small non-coding RNAs derived from precursor tRNAs or mature tRNAs. Depending on the sources, tRFs can be divided into tRF-1, tRF-2, tRF-3, tRF-5, and i-tRF; tiRNAs can be divided into 5'tiRNA and 3'tiRNA. Both tRFs and tiRNAs play important roles in tumorigenesis.
Linwen Zhu +4 more
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