Comprehensive landscape of tRNA-derived fragments in lung cancer [PDF]
Molecular Therapy: Oncolytics, 2022 Transfer RNA (tRNA)-derived fragment (tRDF) is a novel small non-coding RNA that presents in different types of cancer. The comprehensive understanding of tRDFs in non-small cell lung cancer remains largely unknown.
Zitong Gao +11 more
doaj +6 more sources
Protocol for rapid tRNA enrichment and chemiluminescent northern blot detection of tRNA and tRNA-derived fragments [PDF]
STAR ProtocolsSummary: Transfer RNA (tRNA), its post-transcriptional modifications, and tRNA-derived fragments (tRFs) play essential roles in cellular processes and gene regulation.
Pavlina Gregorova +3 more
doaj +5 more sources
tRFTars: predicting the targets of tRNA-derived fragments [PDF]
Journal of Translational Medicine, 2021 Background tRNA-derived fragments (tRFs) are 14–40-nucleotide-long, small non-coding RNAs derived from specific tRNA cleavage events with key regulatory functions in many biological processes.
Qiong Xiao +8 more
doaj +4 more sources
Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance [PDF]
Biomarker Research, 2020 The tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are newly discovered noncoding RNAs in recent years. They are derived from specific cleavage of mature and pre-tRNAs and expressed in various cancers.
Yue Zhang, Huizhu Qian, Jing He, Wen Gao
doaj +3 more sources
Altered levels of angiogenin and tRNA-derived fragments associate with severe asthma [PDF]
Scientific ReportsRecent discoveries highlight angiogenin (ANG) and 5’ tRNA-derived fragments as key factors in stress response and cell survival. To explore their role in asthma pathogenesis, particularly in severe cases, we evaluated the levels of ANG and 5’ tRNA halves
Clara Claus +10 more
doaj +2 more sources
Life, 2015 This review will summarise the recent discoveries and current state of research on short noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs).
Simon P. Keam, Gyorgy Hutvagner
doaj +3 more sources
Expression profiles of exosomal tRNA-derived fragments and their biological functions in lipomas [PDF]
Frontiers in Cell and Developmental Biology, 2022 There is evidence that exosomes derived from the lipoma tissue (Exo-LT) have a stronger capacity to promote the proliferation and migration of adipose-derived stem cells (ADSCs) than those from the adipose tissue (Exo-AT).
Yuxi Zhou +6 more
doaj +2 more sources
Regulatory Roles of Mitochondrial tRNA–Derived Fragments in Cardiovascular Health and Disease [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseMitochondrial tRNA–derived RNA fragments (mt‐tRFs) are small noncoding RNAs generated through specific cleavage. Once considered degradation products, mt‐tRFs are now recognized as bioactive regulatory molecules with critical roles in physiological and ...
Yang Zeng, Qi‐Lan Jiang, Jun Jiang
doaj +2 more sources
Regulatory roles of tRNA-derived RNA fragments in human pathophysiology [PDF]
Molecular Therapy: Nucleic Acids, 2021 Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most abundant type of RNA in the cell. Advancement in deep-sequencing technologies have revealed the presence of abundant expression of functional tRNA-derived ...
Kush Kumar Pandey +7 more
doaj +3 more sources
A versatile and efficient method for detecting tRNA-derived fragments
Molecular and Cellular ProbesRecently, it has been discovered surprisingly that tRNA can be cleaved into specific small fragments under certain conditions. Most importantly, these tRNA-derived fragments (tRFs) participate in the regulation of gene expression, playing pivotal roles ...
Mei Yang +6 more
doaj +3 more sources