Results 21 to 30 of about 45,835 (226)
tRNA-derived fragments (tRFs) in cancer. [PDF]
J Cell Commun Signal, 2023 tRNA fragments (tRNA derived fragments or tRFs) are small single stranded RNA molecules derived from pre-tRNAs and mature tRNAs. tRFs have been known for a number of years, but previously they were believed to be not important products of tRNA degradation. tRFs can be unique, like tRF-1 s, or redundant, like tRF-3 s and tRF-5 s.
Pekarsky Y, Balatti V, Croce CM.
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The Roles of tRNA-Derived Fragments in Cancer: Updates and Perspectives. [PDF]
Int J Mol SciThe non-coding RNAs (ncRNAs) have been reported in numerous studies, and their significant roles in several diseases have been verified subsequently. tRNA-derived fragments (tRFs) are a newly discovered class of small ncRNAs which are produced by mature or precursor tRNAs.
Geng J, Sun Z, Li H.
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Extracellular tRNAs and tRNA-derived fragments [PDF]
RNA Biology, 2020 Fragmentation of tRNAs generates a family of small RNAs collectively known as tRNA-derived fragments. These fragments vary in sequence and size but have been shown to regulate many processes involved in cell homoeostasis and adaptations to stress. Additionally, the field of extracellular RNAs (exRNAs) is rapidly growing because exRNAs are a promising ...
Juan Pablo Tosar, Alfonso Cayota
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tRNA‐derived fragments are promising biomarkers for screening of early colorectal cancer [PDF]
MedComm, 2023 Yanqi Dang +5 more
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Stress Response in Entamoeba histolytica Is Associated with Robust Processing of tRNA to tRNA Halves
mBio, 2023 tRNA-derived fragments have been reported in many different organisms and have diverse cellular roles, such as regulating gene expression, inhibiting protein translation, silencing transposable elements, and modulating cell proliferation.
Manu Sharma +3 more
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tRNA-Derived Fragments as Biomarkers in Bladder Cancer. [PDF]
Cancers (Basel)Bladder cancer (BC) diagnosis is reliant on cystoscopy, an invasive procedure associated with urinary tract infections. This has sparked interest in identifying noninvasive biomarkers in body fluids such as blood and urine. A source of biomarkers in these biofluids are extracellular vesicles (EVs), nanosized vesicles that contain a wide array of ...
Strømme O +5 more
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tRNA-Derived Small RNAs: A Novel Regulatory Small Noncoding RNA in Renal Diseases
Kidney Diseases, 2023 Background: tRNA-derived small RNAs (tsRNAs) are an emerging class of small noncoding RNAs derived from tRNA cleavage. Summary: With the development of high-throughput sequencing, various biological roles of tsRNAs have been gradually revealed, including
Dan Li +6 more
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tRFs and tRNA Halves: Novel Cellular Defenders in Multiple Biological Processes
Current Issues in Molecular Biology, 2022 tRNA fragments derived from angiogenin or Dicer cleavage are referred to as tRNA-derived fragments (tRFs) and tRNA halves. tRFs and tRNA halves have been identified in both eukaryotes and prokaryotes and are precisely cleaved at specific sites on either ...
Jiani Hou +3 more
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tRNA-derived fragments in gastric cancer: Biomarkers and functions. [PDF]
J Cell Mol Med, 2022 AbstracttRNA‐derived fragments (tRFs), non‐coding RNAs that regulate protein expression after transcription, have recently been identified as potential biomarkers. We identified differentially expressed tRFs in gastric cancer (GC) and the biological properties of tRFs in predicting the malignancy status of GCs as possible biomarkers.
Kohansal M +7 more
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Protocol for detection of tRNA-derived fragments in cells, tissues, and plasma. [PDF]
STAR ProtoctRNA-derived fragments (tRFs) are frequently dysregulated in cancers, and approaches for the detection of tRFs within biological samples are vital for their expression analysis and functional exploration. Here, we present a protocol for detecting tRFs using a modified TaqMan quantitative real-time PCR (qRT-PCR)-based technique, Dumbbell-PCR (Db-PCR ...
Yu M, Liu P, Lu Y.
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