Results 31 to 40 of about 45,835 (226)

Transfer RNA-Derived Fragments, the Underappreciated Regulatory Small RNAs in Microbial Pathogenesis

Frontiers in Microbiology, 2021
In eukaryotic organisms, transfer RNA (tRNA)-derived fragments have diverse biological functions. Considering the conserved sequences of tRNAs, it is not surprising that endogenous tRNA fragments in bacteria also play important regulatory roles.
Zhongyou Li, Bruce A. Stanton
doaj   +1 more source

Comprehensive annotation and characterization of planarian tRNA and tRNA-derived fragments (tRFs) [PDF]

RNA, 2020
tRNA-derived fragments (tRFs) have recently gained a lot of scientific interest due to their diverse regulatory roles in several cellular processes. However, their function in dynamic biological process such as development and regeneration remains unexplored. Here, we identify and characterise a role for tRFs in planarian regeneration.
Vairavan Lakshmanan, T.N. Sujith, Dhiru Bansal, Padubidri V. Shivaprasad, Dasaradhi Palakodeti, Srikar Krishna   +5 more
openaire   +3 more sources

Expression profiles and function prediction of tRNA-derived fragments in glioma. [PDF]

BMC Cancer, 2023
Abstract Background Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. The transfer RNA-derived fragments (tRFs) are a new group of small noncoding RNAs, which are dysregulated in many cancers.
Wei D, Niu B, Zhai B, Liu XB, Yao YL, Liang CC, Wang P.   +6 more
europepmc   +4 more sources

Arabidopsis tRNA-derived fragments as potential modulators of translation [PDF]

RNA Biology, 2020
Transfer RNA-derived fragments (tRFs) exist in all branches of life. They are involved in RNA degradation, regulation of gene expression, ribosome biogenesis. In archaebacteria, kinetoplastid, yeast, and human cells, they were also shown to regulate translation.
Lalande, Stéphanie, Merret, Rémy, Salinas-Giegé, Thalia, Drouard, Laurence   +3 more
openaire   +2 more sources

Conserved and highly expressed tRNA derived fragments in zebrafish [PDF]

BMC Molecular Biology, 2015
Small non-coding RNAs (sncRNAs) are a class of transcripts implicated in several eukaryotic regulatory mechanisms, namely gene silencing and chromatin regulation. Despite significant progress in their identification by next generation sequencing (NGS) we are still far from understanding their full diversity and functional repertoire.Here we report the ...
Soares, Ana Raquel, Fernandes, Noémia, Reverendo, Marisa, Araújo, Hugo Rafael, Oliveira, José Luís, Moura, Gabriela M. R., Santos, Manuel A. S.   +6 more
openaire   +3 more sources

tRNA Biology in Trypanosomes

CHIMIA, 2019
Besides their medical importance, the parasitic protozoan Trypanosoma brucei and its relatives are experimentally highly accessible model systems for many cell biological processes.
Shikha Shikha, Rebecca Brogli, André Schneider, Norbert Polacek   +3 more
doaj   +1 more source

Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases [PDF]

Genomics & Informatics, 2015
tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles
Yu Fu, Inhan Lee, Yong Sun Lee, Xiaoyong Bao   +3 more
doaj   +1 more source

Distinct subcellular localization of tRNA-derived fragments in the infective metacyclic forms of Trypanosoma cruzi

Memorias do Instituto Oswaldo Cruz, 2012
Small non-coding RNAs derived from transfer RNAs have been identified as a broadly conserved prokaryotic and eukaryotic response to stress. Their presence coincides with changes in developmental state associated with gene expression regulation.
Larissa Reifur, Maria Rosa Garcia-Silva, Saloê Bispo Poubel, Lysangela Ronalte Alves, Paulo Arauco, Diane Kelly Buiar, Samuel Goldenberg, Alfonso Cayota, Bruno Dallagiovanna   +8 more
doaj   +1 more source

Expression profile of tRNA‑derived fragments in pancreatic cancer

Oncology Letters, 2019
Pancreatic cancer is a deadly disease, the deadliest of all the solid tumors; the 5-year survival rate of patients with this disease is ~8%. Previously, high-throughput sequencing has led to the discovery of novel small non-coding RNAs, also known as transfer RNA-derived fragments (tRFs).
Jin, Lei, Zhu, Chunfu, Qin, Xihu
openaire   +3 more sources

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source