Results 121 to 130 of about 4,159 (191)

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, Volume 16, Issue 8, Page 1452-1458, August 2026.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, Volume 13, Issue 46, 17 August 2026.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

Proteomic Differentiation of Colorectal Cancer From Normal Tissue via Ex Vivo E‐Biopsy: A Novel Approach to Molecular Sampling for Diagnostic Precision

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Colorectal cancer (CRC) is one of the most common malignancies worldwide. Early and accurate diagnosis remains a clinical priority, yet current biopsy techniques are invasive, spatially limited, and may not capture the molecular heterogeneity of tumors.
Gintautas Saulis, Edward Vitkin, Rita Saule, Julia Wise, Antanas Gulbinas, Žilvinas Dambrauskas, Sandra Ivanauskienė, Justas Žilinskas, Lina Poskiene, Alexander Golberg   +9 more
wiley   +1 more source

Morphological Characterization and Complete Mitochondrial Genome of a New Epizoic Hexamerous Brittle Star Gymnolophus sexradia sp. Nov

Ecology and Evolution, Volume 16, Issue 8, August 2026.
This study describes a new hexamerous epizoic brittle star species, Gymnolophus sexradia sp. nov., from the South China Sea, which lives on crinoid hosts and exhibits a six‐armed body plan possibly indicating fissiparity. Its vertebral and arm plate structures enhance horizontal flexibility for grasping the host, and phylogenetic analysis based on ...
Ziye Zhang, Weilin Xiao, Chao Zhang, Chunyan Li, Huixian Zhang, Zelin Chen   +5 more
wiley   +1 more source

De Novo Assembly and Comparative Mitochondrial Genome Analysis of Three Salt Marsh Specialist Ground Beetle Species (Coleoptera: Carabidae)

Ecology and Evolution, Volume 16, Issue 8, August 2026.
We assembled and analyzed the complete mitochondrial genomes of 10 individuals from the salt marsh ground beetles Bembidion minimum, Dicheirotrichus gustavii, and Pogonus chalceus, revealing the conserved insect gene order, the typical set of 37 mitochondrial genes, and a pronounced AT‐bias (~80%).
Anne Mack, Michael Kuhlmann, Christine Ewers   +2 more
wiley   +1 more source

Mitochondrial Genome Sequencing and Phylogenetic Analysis of Myotis pequinius and M. chinensis

Ecology and Evolution, Volume 16, Issue 8, August 2026.
This study first determined the complete mitochondrial genomes of Myotis pequinius (17,395 bp) and M. chinensis (17,014 bp), which both contain 13 protein‐coding genes, 22 tRNAs, 2 rRNAs, and a D‐loop, exhibiting an AT‐rich base composition. Phylogenetic analysis based on the 13 protein‐coding genes revealed that the two species are closely related and
Xufan Wang, Xiangxiang Cao, Haiyan Guan, Huigen Feng, Sen Liu   +4 more
wiley   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

tRNA halves: a striking new discovery in pre-eclampsia

, 2021
Cooke, W, Cribbs, A, Zhang, W, Kandzija, N, Motta-Mejia, C, Dombi, E, Ri, R, Cerdeira, AS, Redman, C, Vatish, M   +9 more
openaire   +1 more source