Results 171 to 180 of about 4,159 (191)

Emerging roles and therapeutic potential of tRNA-Derived small RNAs in reproductive system diseases: a review. [PDF]

Front Cell Dev Biol
Zhou Q, He M, Liu M, Sun G, Li J.
europepmc   +1 more source

Coupling tRNAGly gene redundancy with staphylococcal cell wall integrity, antibiotic susceptibility, and virulence potential. [PDF]

Nucleic Acids Res
Kouvela A, Jaramillo Ponce JR, Giarimoglou N, Chicher J, Marzi S, Stathopoulos C, Stamatopoulou V.   +6 more
europepmc   +1 more source

Mechanisms of Transfer RNA Fragments Functionality Within and Between Cells and Organisms. [PDF]

Cells
Vaidhyanathan S, Lin YX, Adetowubo AA, Kiliç F, Jonnalagadda SA, Grigoriev A.   +5 more
europepmc   +1 more source

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tRNA-halves are prognostic biomarkers for patients with prostate cancer

Urologic Oncology: Seminars and Original Investigations, 2018
Noncoding RNAs play an important role in carcinogenesis; a number of tRNA-halves are expressed in response to androgen stimulation and are involved in prostate cancer (CaP) initiation and progression. In this study, we evaluated the expression profile of androgen-dependent tRNA-halves in CaP.Total RNA was isolated from formalin-fixed paraffin-embedded ...
Yuri Tolkach, Jörg Ellinger, Michael Muders   +2 more
exaly   +3 more sources

tRNA-derived fragments and tRNA halves: The new players in cancers

Cancer Letters, 2019
tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are small non-coding RNAs derived from precursor tRNAs or mature tRNAs. Depending on the sources, tRFs can be divided into tRF-1, tRF-2, tRF-3, tRF-5, and i-tRF; tiRNAs can be divided into 5'tiRNA and 3'tiRNA. Both tRFs and tiRNAs play important roles in tumorigenesis.
Tianwen Li, Jiaxin Ge, Junming Guo
exaly   +3 more sources

Transfer RNA-derived fragments and tRNA halves: biogenesis, biological functions and their roles in diseases

Journal of Molecular Medicine, 2018
The number of studies on non-coding RNAs has increased substantially in recent years owing to their importance in gene regulation. However, the biological functions of small RNAs from abundant species of housekeeping non-coding RNAs (rRNA, tRNA, etc.) remain a highly studied topic.
Zhilong Yan, Tianwen Li, Junming Guo
exaly   +3 more sources

Maternal circulating syncytiotrophoblast-derived extracellular vesicles contain biologically active 5’-tRNA halves [PDF]

Biochemical and Biophysical Research Communications, 2019
Abstract The placenta releases syncytiotrophoblast-derived extracellular vesicles (STB-EV) into the maternal circulation throughout gestation. STB-EV dependent signalling is believed to contribute to the widespread maternal adaptive physiological changes seen in pregnancy.
Adam Cribbs, Manu Vatish, Eszter Dombi   +2 more
exaly   +4 more sources

Stress Induced tRNA Halves (tiRNAs) as Biomarkers for Stroke and Stroke Therapy; Pre-clinical Study

Neuroscience, 2020
tiRNAs are small non-coding RNAs generated by angiogenin-mediated tRNA cleavage during cellular stress. Some tiRNAs were shown to be cytoprotective, while other reports indicate that the generation of tiRNAs is cytotoxic. We used rat model of focal cerebral ischemia-reperfusion (I/R) injury to study the generation and regulation of tiRNAs following in ...
Kuniyasu Niizuma, Rashad S, Teiji Tominaga   +2 more
exaly   +3 more sources

5′-tRNA Halves are Dysregulated in Clear Cell Renal Cell Carcinoma

Journal of Urology, 2018
In various malignancies RNA fragments are dysregulated. Our study was designed to determine the expression of 4, 5'-tRNA halves in the tissue and serum of patients with clear cell renal cell carcinoma.Tissue and serum samples of patients with clear cell renal cell carcinoma and nonmalignant disease were collected prospectively in our biobank.
Chenming, Zhao, Yuri, Tolkach, Doris, Schmidt, Glen, Kristiansen, Stefan C, Müller, Jörg, Ellinger   +5 more
openaire   +2 more sources

Quantitative and qualitative detection of tRNAs, tRNA halves and tRFs in human cancer samples: Molecular grounds for biomarker development and clinical perspectives

Gene
Transfer RNAs (tRNAs) are small non-coding RNAs playing a central role during protein synthesis. Besides translation, growing evidence suggests that in many contexts, precursor or mature tRNAs can also be processed into smaller fragments playing many non-canonical regulatory roles in different biological pathways with oncogenic relevance.
Chiara Cabrelle, Federico M Giorgi, Daniele Mercatelli   +2 more
exaly   +3 more sources