Emerging roles of tRNA modification-mediated codon-specific translational reprogramming in cancer biology [PDF]
Cell Death and DiseaseCancer has become a leading cause of mortality worldwide, with alarming increases in incidence and mortality rates. Emerging evidence suggests that tRNA modification enzymes play a crucial role in cancer development by modulating codon-specific ...
Hanwei Wang +3 more
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A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth [PDF]
eLife, 2023 Diverse chemical modifications fine-tune the function and metabolism of tRNA. Although tRNA modification is universal in all kingdoms of life, profiles of modifications, their functions, and physiological roles have not been elucidated in most organisms ...
Francesca G Tomasi +3 more
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Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator [PDF]
Toxins, 2017 Saccharomyces cerevisiae cells are killed by zymocin, a tRNase ribotoxin complex from Kluyveromyces lactis, which cleaves anticodons and inhibits protein synthesis.
Constance Mehlgarten +11 more
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Parent tRNA Modification Status Determines the Induction of Functional tRNA-Derived RNA by Respiratory Syncytial Virus Infection [PDF]
Viruses, 2022 tRNA-derived RNA fragments (tRFs) are a recently discovered family of small noncoding RNAs (sncRNAs). We previously reported that respiratory syncytial virus (RSV) infection induces functional tRFs, which are derived from a limited subset of parent tRNAs,
Eun-Jin Choi +10 more
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Mettl1-dependent m7G tRNA modification is essential for maintaining spermatogenesis and fertility in Drosophila melanogaster [PDF]
Nature CommunicationsModification of guanosine to N7-methylguanosine (m7G) in the variable loop region of tRNA is catalyzed by the METTL1/WDR4 heterodimer and stabilizes target tRNA. Here, we reveal essential functions of Mettl1 in Drosophila fertility.
Shunya Kaneko +12 more
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METTL1-mediated m7G tRNA modification drives papillary thyroid cancer progression and metastasis by regulating the codon-specific translation of TNF-α [PDF]
Cell Death and DiseaseN7-methylguanosine (m7G) modification of transfer RNA (tRNA) is essential for the biological functions of tRNAs and has been found to play a regulatory role in a variety of human cancers.
Weiwei Li +9 more
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Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease [PDF]
eLifeNonstructural protein 5 (Nsp5) is the main protease of SARS-CoV-2 that cleaves viral polyproteins into individual polypeptides necessary for viral replication.
Kejia Zhang +8 more
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Detection of genetic variation and activity analysis of the promoter region of the cattle tRNA-modified gene TRDMT1 [PDF]
Archives Animal Breeding, 2021 The tRNA modification gene in eukaryotes is relatively conservative. As an important modification gene, the TRDMT1 gene plays an important role in maintaining tRNA structural maintenance and reducing mistranslation of protein translation by methylation ...
X. Yi +6 more
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Examining the Gm18 and mG Modification Positions in tRNA Sequences [PDF]
Genomics & Informatics, 2014 The tRNA structure contains conserved modifications that are responsible for its stability and are involved in the initiation and accuracy of the translation process. tRNA modification enzymes are prevalent in bacteria, archaea, and eukaryotes. tRNA Gm18
Mayavan Subramanian +2 more
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Computational and Structural Biotechnology Journal, 2023 Modification of tRNA is an integral part of the epitranscriptome with a particularly pronounced potential to generate diversity in RNA expression. Eukaryotic tRNA contains modifications in up to 20% of their nucleotides, but not all sites are always ...
Florian Pichot +9 more
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